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Table 1 Characteristics of trials included in the analysis

From: Probiotics for infantile colic: a systematic review

Study/year/reference Description/study design Birth weight and age at enrolment Probiotic agent(s) Dosage and duration Control arm Primary outcome
Savino/2007 [24] April 2004 - May 2005. Birth weight 2500-4000 g and aged 21–90 days L. reuteri (American Type Culture Collection Strain 55730) 108 colony-forming units in 5 drops for 28 days Simethicone A reduction of average crying time to less than 3 hours a day on day 28.
90 exclusively breastfed infants with a diagnosis of infantile colic.
Recruited in the Department of Pediatric and Adolescence Science (Regina Margherita Children Hospital, Turin, Italy)
Open prospective randomized study.
Savino/2010 [25] March 2008 and August 2009. Birth weight 2500–4000 g and aged 2–16 weeks L. reuteri DSM 17938 108 colony-forming units in 5 drops, once a day, 30 minutes before the feed in the morning, for 21 days Placebo A reduction of average crying time to less than 3 hours a day on day 21.
50 exclusively breastfed infants were recruited from general pediatricians and outpatients at the Department of Pediatrics, University of Turin (Regina Margherita Children Hospital)
A Randomized, Double-Blind, Placebo-Controlled Trial
Szajewska/2013 [26] January 2010 and December 2011. Full term infants aged <5 months L. reuteri DSM 17938 108 colony-forming units in 5 drops, orally, once a day, for 21 days Placebo The percentage of children achieving a reduction in the daily average crying time more than 50% and the duration of crying at 7, 14, 21, and 28 days after randomization.
80 exclusively or predominantly (>50%) breastfed infants
Family primary care practice in Warsaw, Poland
A Randomized, Double-Blind, Placebo-Controlled Trial
  1. Colic in all the trials was defined as crying episodes lasting ≥3 hours/day and occurring at least 3 days/week within 7 days prior to enrollment.