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Table 1 Patient characteristics and outcome variables in relation to cumulative human milk intake until d 28

From: Early feeding of fortified breast milk and in-hospital-growth in very premature infants: a retrospective cohort analysis

 

> 75% human milk

< 25% human milk

p-value by Wilcoxon test

Number of infants [n/N] (m/f) [n/n]

122/206 (48/74)

37/206 (21/16)

 

Gestational age at birth [weeks] median (IQR) (range)

27.6 (25.5-29.7) (23.0-31.7)

28.6 (25.6-30.5) (23.7-31.9)

p = 0.3

Birth weight [g] median (IQR) (range)

925 (665-1175) (290-1490)

846 (705-1160) (340-1490)

p = 0.9

CRIB-score median (IQR)

4 (1-7)

4 (1-6)

p = 0.42

Incidence of necrotizing enterocolitis [n/N]

3/122

2/37

p = 0.33 (Fisher’s exact)

Day of life when full enteral feeds were attained median (IQR)

8 (6-10)

8 (6-10)

p = 0.68

Cumulative energy intake (*) [kcal/kg] first four weeks of life median (IQR)

3431 (3219-3601)

3438 (3356-3562)

p = 0.58

Cumulative protein intake (**) [g/kg] first four weeks of life median (IQR)

105 (101-110)

109 (105-116)

p = 0.002

SDS-difference for weight (SDSd28 – SDSbirth) median (IQR)

-0.64 (-1.08-0.34)

-0.41 (-0.7-0.17)

p = 0.017

Postmenstrual age at discharge [weeks] median (IQR)

38.1 (36.5-40)

38.3 (36-40.3)

p = 0.48

Age at discharge [days] median (IQR)

72 (48-98)

69 (44-93)

p = 0.41

  1. IQR = interquartile range.
  2. (*) = assuming human milk energy content of 67 kcal/100 ml.
  3. (**) = assuming human milk protein content of 1.4 g/100 ml.