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Table 3 Emerging approaches to surfactant administration

From: Exogenous surfactant therapy in 2013: what is next? who, when and how should we treat newborn infants in the future?

Emerging approaches

Advantages

Disadvantages

MIST

Nasopharyngeal instillation

Painless

Not well evaluated

Loss of surfactant

Laryngeal mask

Supraglottic device

Painful

Feeding catheter

Endotracheal administration Under nasal CPAP

Magill forceps

Laryngoscopy

Painful and traumatic?

Vascular catheter

Endotracheal administration

Laryngoscopy

Under nasal CPAP

Painful and traumatic

Easy to use (rigid catheter)

 

NIST

Aerosolization

Painless

Technically challenging

  1. MIST: Minimally-Invasive Surfactant Therapy.
  2. NIST: Non-Invasive Surfactant Therapy.