Table 2 Recent studies concerning CPAP and surfactant administration

COIN Trial (78)

2008

610

25-28 wks

CPAP

Systematic intubation

Death or BPD

33.9%

38.9%

Intubation

46%

100%

Selective surfactant

38%***

77%

Pneumothorax

9%***

3%

Rojas et al. (79)

2009

279

27-31 wks

CPAP

Intubation-early surfactant-extubation

Need for MV

39%*

26%

Pneumothorax

9%

2%

Rescue surfactant

26%**

12%

BPD at 36 wks PMA

59%

49%

CURPAP Trial (80)

2010

208

25-28 wks

CPAP Early selective Surfactant

Prophylactic surfactant

Need for MV

33%

31.4%

Death at 36 wks PMA

10.7%

8.6%

Pneumothorax

1%

6.7%

BPD

11.7%

14.3%

SUPPORT Trial (81)

2010

1316

24-28 wks

CPAP

Intubation-early surfactant use

Death or BPD

48.7%

54.1%

Surfactant use

67.1%***

98.9%

Air leak

6.8%

7.4%

Dunn et al. (82)

2011

648

26-29 wks

CPAP Selective surfactant

Prophylactic surfactant

Intubation-early surfactant-extubation

Surfactant use

14.8%***

98.6%

98.2%

Death or BPD

30.5%

36.5%

28.5%

Pneumothorax

5.4%

4.8%

3.2%