|
Item
|
Multiple-center
|
Single-center
|
p
|
Teaching hospitals*
|
Non-teaching
|
p
|
Funding
|
No funding
|
p
|
2002-2006
|
2007-2011
|
p
|
|---|
| |
(n = 25)
|
(n = 1052)
| |
(n = 254)
|
hospitals* (n = 818)
| |
(n = 44)
|
(n = 1033)
| |
(n = 446)
|
(n = 631)
| |
|---|
|
Adequate random
|
13 (52%)
|
148 (14.06%)
|
0.000
|
46 (18.11%)
|
114 (13.94%)
|
0.103
|
6 (13.64%)
|
155 (15%)
|
0.803
|
12 (2.69%)
|
149 (23.61%)
|
0.000
|
|
sequence generation
| | | | | | | | | | | | |
|
(n = 161)
| | | | | | | | | | | | |
|
Adequate allocation
|
5 (20%)
|
5 (0.48%)
|
0.000
|
9 (3.54%)
|
1 (0.12%)
|
0.000
|
3 (6.82%)
|
7 (0.68%)
|
0.006
|
1 (0.22%)
|
9 (1.43%)
|
0.053
|
|
concealment
| | | | | | | | | | | | |
|
(n = 10)
| | | | | | | | | | | | |
|
Adequate blinding
|
2 (8%)
|
4 (0.38%)
|
0.007
|
5 (1.97%)
|
0 (0%)
|
0.001
|
1 (2.27%)
|
5 (0.48%)
|
0.222
|
1 (0.22%)
|
5 (0.79%)
|
0.410
|
|
(n = 6)
| | | | | | | | | | | | |
|
Incomplete outcome
|
12 (48%)
|
976 (92.78%)
|
0.000
|
214 (84.25%)
|
769 (94.01%)
|
0.000
|
29 (65.9%)
|
959 (92.84%)
|
0.000
|
416 (93.27%)
|
572 (90.65%)
|
0.123
|
|
data (low risk)
| | | | | | | | | | | | |
|
(n = 988)
| | | | | | | | | | | | |
|
Selective reporting
|
0 (0%)
|
18 (1.71%)
|
1.000
|
3 (1.18%)
|
15 (1.83%)
|
0.588
|
0 (0%)
|
18 (1.74%)
|
1.000
|
6 (1.35%)
|
12 (1.9%)
|
0.483
|
|
(n = 18)
| | | | | | | | | | | | |
- *We excluded five studies conducted in scientific research institutions.
