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Table 4 Outcome prediction at birth: sensitivity analyses excluding infants that died in delivery room (n = 130): Uni- and multivariate association of clinical and demographic parameters known at birth with mortality, adverse outcome and unfavourable outcome

From: Outcome at two years of age in a Swiss national cohort of extremely preterm infants born between 2000 and 2008

MORTALITY

Univariate model†

 

Multivariate model‡

 
 

OR (95%-CI)

p-value

OR (95%-CI)

p-value

Gestational age (weeks)

0.47 (0.41 - 0.55)

<0.001

0.46 (0.39 - 0.54)

<0.001

BW z-score

0.66 (0.56 - 0.77)

<0.001

NA

 

BW z-score < −2

6.92 (2.89 - 16.59)

<0.001

10.09 (4.01 - 25.40)

<0.001

BW z-score −2 to −1

2.02 (1.35 - 3.02)

<0.001

2.52 (1.63 - 3.90)

<0.001

Male sex

1.13 (0.86 - 1.49)

0.38

1.16 (0.86 - 1.57)

0.33

Outborn

1.15 (0.64 - 2.06)

0.65

NA

 

Antenatal corticosteroids

0.52 (0.39 - 0.70)

<0.001

0.55 (0.41 - 0.76)

<0.001

Caesarean delivery

0.77 (0.55 - 1.06)

0.1

NA

 

Multiple pregnancy

0.94 (0.69 - 1.29)

0.72

1.28 (0.90 - 1.81)

1.17

ADVERSE OUTCOME

Univariate model†

 

Multivariate model‡

 
 

OR (95%-CI)

p-value

OR (95%-CI)

p-value

Gestational age (weeks)

0.56 (0.49 - 0.65)

<0.001

0.55 (0.47 - 0.64)

<0.001

BW z-score

0.73 (0.62 - 0.85)

<0.001

NA

 

BW z-score < −2

4.99 (1.98 - 12.56)

<0.001

6.74 (2.58 - 17.60)

<0.001

BW z-score −2 to −1

1.82 (1.22 - 2.72)

0.003

2.20 (1.44 - 3.36)

<0.001

Male sex

1.29 (0.98 - 1.69)

0.066

1.35 (1.01 - 1.80)

0.041

Outborn

1.34 (0.73 - 2.47)

0.34

NA

 

Antenatal corticosteroids

0.58 (0.44 - 0.78)

<0.001

0.61 (0.45 - 0.83)

0.002

Caesarean delivery

0.79 (0.57 - 1.09)

0.15

NA

 

Multiple pregnancy

0.91 (0.67 - 1.23)

0.55

1.17 (0.85 - 1.63)

0.34

UNFAVOURABLE OUTCOME

Univariate model†

 

Multivariate model‡

 
 

OR (95%-CI)

p-value

OR (95%-CI)

p-value

Gestational age (weeks)

0.60 (0.52 - 0.68)

<0.001

0.59 (0.51 - 0.68)

<0.001

BW z-score

0.75 (0.64 - 0.87)

<0.001

NA

 

BW z-score < −2

11.32 (2.60 - 49.16)

0.001

15.24 (3.43 - 67.71)

<0.001

BW z-score −2 to −1

1.47 (0.96 - 2.19)

0.059

1.69 (1.12 - 2.57)

0.013

Male sex

1.30 (1.00 - 1.67)

0.049

1.35 (1.02 - 1.78)

0.033

Outborn

1.65 (0.87 - 3.15)

0.13

NA

 

Antenatal corticosteroids

0.64 (0.48 - 0.86)

0.002

0.66 (0.49 - 0.89)

0.006

Caesarean delivery

0.96 (0.70 - 1.33)

0.82

NA

 

Multiple pregnancy

1.01 (0.76 - 1.35)

0.94

1.29 (0.94 - 1.76)

0.11

  1. The table gives all parameters that showed an unequal distribution among groups as shown in Table I or that are known from previous publications to act as confounders. † The univariate model is adjusted for study centre and year group. ‡ The multivariate model contains all parameters that were associated with the outcome in the univariate model.
  2. OR, Odd’s ratio; CI, confidence interval; BW, birth weight.
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BMC Pediatrics

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