Table 1 Risk of asthma, recurrent wheeze and bronchial hyperreactivity with various metrics of environmental tobacco smoke
From: Cotinine versus questionnaire: early-life environmental tobacco smoke exposure and incident asthma
2 years | 7 years | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Recurrent wheeze | Asthma | Bronchial hyperreactivity | ||||||||
Yes | No | Adjusted* OR# | Yes | No | Adjusted OR | Yes | No | Adjusted OR | ||
Measures at 3rd trimester/birth | Maternal smoking (self-reported) during 3rd trimester | 5/23 (21.7) | 18/252 (7.1) | 3.5 (1.2,10.7) p=0.025 | 4/50 (8.0) | 19/229 (8.3) | 0.5 (0.1,1.6) | 11/146 (7.5) | 9/112 (8.0) | 0.9 (0.4,2.3) |
Any family member smoking (self-reported) during 3rd trimester | 11/23 (47.8) | 60/252 (23.8) | 2.9 (1.2,7.0) p=0.015 | 14/50 (28.0) | 58/229 (25.3) | 0.9 (0.4,1.9) | 38/146 (26.0) | 29/112 (25.9) | 1.0 (0.6,1.8) | |
Cord blood cotinine above 50th percentile | 16/23 (69.6) | 119/252 (47.2) | 2.6 (1.0,6.5) p=0.045 | 31/50 (62.0) | 106/229 (46.3) | 1.7 (0.9,3.2) | 74/146 (50.7) | 51/112 (45.5) | 1.2 (0.7,2.0) | |
Measures at 12 months | Maternal smoking (self-reported) at 12 months | 4/33 (12.1) | 29/332 (8.7) | 1.3 (0.4,4.1) | 5/71 (7.0) | 28/299 (9.4) | 0.3 (0.1,1.0) | 15/188 (8.0) | 15/150 (10.0) | 0.8 (0.4,1.7) |
Any family member smoking (self-reported) at 12 months | 10/33 (30.3) | 66/332 (19.9) | 1.7 (0.8,3.8) | 15/71 (21.1) | 62/299 (20.7) | 0.7 (0.3,1.4) | 45/188 (23.9) | 27/150 (18.0) | 1.5 (0.9,2.7) | |
Urinary cotinine:Cr above 50th percentile at 12 months | 23/33 (69.7) | 167/332 (50.3) | 2.2 (0.99,4.7) | 43/71 (60.6) | 149/299 (49.8) | 1.2 (0.7,2.1) | 94/188 (50.0) | 79/150 (52.7) | 0.9 (0.6,1.3) | |