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Table 3 Prevalence and odds ratios (and 95% CI) of asthma and atopic sensitization at age 8–9 by mode of delivery, stratified by family history of allergy

From: Asthma and atopy in children born by caesarean section: effect modification by family history of allergies – a population based cross-sectional study

 

NO FAMILY HISTORY OF ALLERGY

FAMILY HISTORY OF ALLERGY

Effect modification p-value‡

 

Vaginal Prevalence %(95%CI)

Caesarean Prevalence % (95%CI)

Unadjusted Odds Ratios (95% CI)

Adjusted Odds Ratios† (95% CI)

Vaginal Prevalence % (95%CI)

Caesarean Prevalence % (95%CI)

Unadjusted Odds Ratios (95% CI)

Adjusted Odds Ratios† (95% CI)

All children*

N=929

N=413

  

N=531

N=259

   

Ever Wheeze

15.2(12.9-17.5)

19.9 (16.0-23.8)

1.38 (1.02-1.87)

1.45 (1.05-2.00)

37.3 (33.2-41.4)

44.8 (38.7-50.9)

1.36 (1.00-1.83)

1.27 (0.92-1.75)

0.55

Current Wheeze

4.1 (2.8-5.4)

6.8 (4.4-9.2)

1.70 (1.03-2.82)

1.54 (0.89-2.64)

13.7 (10.8-16.6)

17.8 (13.1-22.5)

1.37 (0.92-2.06)

1.07 (0.69-1.66)

0.31

Ever Asthma

10.5 (8.5-12.5)

13.3 (10.0-16.6)

1.30 (0.91-1.84)

1.40 (0.96-2.05)

25.6 (21.9-29.3)

34.4 (28.6-40.2)

1.54 (1.11-2.12)

1.42 (1.00-2.01)

0.96

Active Asthma

2.7 (1.7-3.7)

3.4 (1.7-5.1)

1.26 (0.65-2.46)

1.19 (0.57-2.46)

9.6 (7.1-12.1)

13.5 (9.3-17.7)

1.49 (0.94-2.36)

1.25 (0.76-2.07)

0.90

Sub-group*

N=289

N=137

  

N=204

N=89

   

Atopic sensitization

14.8 (10.8-18.8)

15.0 (9.2-20.8)

1.04 (0.60-1.81)

1.16 (0.64-2.11)

12.1 (7.8-16.4)

24.2 (15.8-32.6)

2.42 (1.30-4.96)

2.62 (1.38-5.00)

0.06

  1. † Adjusted for sex, country of birth, district of residence, urban/rural residence, birth order, parental level of education, parental smoking at home, mother smoking during pregnancy, birth weight < 2500 gr., exclusive breastfeeding for more than 2 months, nursery attendance in the first year of life, bedroom sharing with older sibling. ‡ P-value for effect modification by family history of allergy in multivariable models. * Numbers reflect missing values on some variables.
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BMC Pediatrics

ISSN: 1471-2431

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