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Table 5 Medical Characteristics by Seizure Group.

From: Traditional and non-traditional treatments for autism spectrum disorder with seizures: an on-line survey

Medical Diagnosis Overall Control Clinical Seizures Subclinical Seizures
Prematurity 15% 13% 15% ns 16% ns,ns
Cerebral Palsy 4% 1% 5% ns 3% ns,ns
Sensory Integration Disorder 51% 53% 48% ns 58% ns,ns
ADHD 31% 31% 30% ns 31% ns,ns
Hypotonia 24% 20% 26% ns 27% ns,ns
Mental Retardation 20% 7% 28% 18% ns,ns
Mitochondrial disorder 10% 6% 11% ns 17% ns,ns
Genetic Disorder 6% 4% 7% ns 7% ns,ns
Renal disease 2% 2% 2% ns 1% ns,ns
Cardiovascular disease 2% 2% 2% ns 2% ns,ns
Hematological disease 1% 1% 1% ns 1% ns,ns
  Growth
Failure-to-Thrive 14% 11% 14% ns 15% ns,ns
Macrocephaly 11% 9% 11% ns 13% ns,ns
Accelerated Growth 10% 11% 9% ns 9% ns,ns
Microcephaly 4% 4% 4% ns 3% ns,ns
  Gastrointestinal Disorders
Constipation 41% 39% 42% ns 40% ns,ns
GERD 22% 22% 22% ns 25% ns,ns
Inflammation 17% 12% 18% ns 24% ns,ns
Dysbiosis 16% 12% 16% ns 22% ns,ns
LNH 4% 2% 4% ns 7% ns,ns
  Sleep Disorders
Disrupted Sleep 44% 34% 47% ns 53% ns,ns
Insomnia 22% 27% 34% ns 33% ns,ns
Apnea 9% 8% 9% ns 9% ns,ns
PLMS 6% 5% 6% ns 9% ns,ns
  1. †p < = 0.0001
  2. For each characteristic listed, statistical comparisons were made between the clinical seizure group and the control group (superscript after the clinical seizure percentage), the subclinical seizure group and the control group (1st superscript after the subclinical seizure percentage) and between the clinical and subclinical seizure group (2nd superscript after the subclinical seizure percentage). There are 24 medical diagnoses and 3 comparisons for each medical diagnosis resulting in 72 comparisons. The Bonferroni correction results in an alpha of 0.05/72 = 0.0007, so we have set the alpha to p < = 0.0001 to be conservative.