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Table 3 Sensitivity and specificity of select clinical findings and events for distinguishing HIV-infected from exposed uninfected infants

From: Utility of clinical parameters to identify HIV infection in infants below ten weeks of age in South Africa: a prospective cohort study

 

All exposed infants

Characteristic

Sensitivity (95%CI)

Specificity (95%CI)

+ LR

General LAD

14.6 (11.8-17.9)

97.6 (93.1-99.5)

6.1

Any LAD

24.4 (20.9-28.3)

95.2 (89.8-98.2)

4.8

Hepatomegaly

13.0 (10.2-16.1)

99.2 (95.6-100)

13

Splenomegaly

5.6 (3.8-7.8)

100

n/a

Oral thrush

30.2 (26.3-34.2)

89.6 (82.8-94.3)

164

Diaper rash

35.7 (31.1-40.5)

81.6 (12-26.3)

1.9

Reflux

2.8 (1.6-2.5)

100

n/a

Weight < 3rd

14.6 (11.7-17.9)

93.6 (87.8-97.2)

2.3

Weight < 15th

30.7 (26.9-34.8)

81.6 (73.7-87.9)

1.7

  1. WAZ - weight-for-age score. CI - confidence interval.
  2. +LR - positive likelihood ratio. n/a - not applicable.