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Table 3 Sensitivity and specificity of select clinical findings and events for distinguishing HIV-infected from exposed uninfected infants

From: Utility of clinical parameters to identify HIV infection in infants below ten weeks of age in South Africa: a prospective cohort study

  All exposed infants
Characteristic Sensitivity (95%CI) Specificity (95%CI) + LR
General LAD 14.6 (11.8-17.9) 97.6 (93.1-99.5) 6.1
Any LAD 24.4 (20.9-28.3) 95.2 (89.8-98.2) 4.8
Hepatomegaly 13.0 (10.2-16.1) 99.2 (95.6-100) 13
Splenomegaly 5.6 (3.8-7.8) 100 n/a
Oral thrush 30.2 (26.3-34.2) 89.6 (82.8-94.3) 164
Diaper rash 35.7 (31.1-40.5) 81.6 (12-26.3) 1.9
Reflux 2.8 (1.6-2.5) 100 n/a
Weight < 3rd 14.6 (11.7-17.9) 93.6 (87.8-97.2) 2.3
Weight < 15th 30.7 (26.9-34.8) 81.6 (73.7-87.9) 1.7
  1. WAZ - weight-for-age score. CI - confidence interval.
  2. +LR - positive likelihood ratio. n/a - not applicable.