A prospective study of the sensitivity, specificity and diagnostic performance of soluble intercellular adhesion molecule 1, highly sensitive C-reactive protein, soluble E-selectin and serum amyloid A in the diagnosis of neonatal infection

Table 4 Study measurements in the clinical groups

Clinical group	Controls (n = 27)	Not Infected (n = 118)	Infected (n = 74)
				Culture positive (n = 41)	Culture Negative (n = 33)
Duration of antibiotic therapy (days)	0 (0,0)	2 (1,3)	5 (5,7)	7 (5,7)	5 (5,7)
sICAM-1 (ng/ml),	165 (130,290)	168 (140,228)	341 (236,554) P < 0.001	405 (252,666) P < 0.001	306 (230,484) P < 0.001
hsCRP(mg/l),	0.1 (0.1,0.4)	0.1 (0.1,0.7)	0.85 (0.3,15.9) P < 0.001	2.0 (0.7,21.2) P < 0.001	0.45 (0.1,2.2) P = 0.012
SAA(mg/l)	0.9 (0.9,1.0)	1.0 (0.9,2.0)	1.5 (0.9,5.8) P = 0.004	2.0 (1.0-10.0) P = 0.001	1.0 (0.9,2.0) P > 0.05
sE-selectin(ng/ml)	71 (51,118)	90 (59,124)	135 (94,192) P < 0.001	158 (94,207) P < 0.001	109 (92,184) P = 0.009

Levels of test measurements in each clinical group and duration of antibiotic therapy is provided. All data quoted as (median, (1^st, 3^rd quartiles)).
Statistical comparison between infected and not infected groups (Mann Whitney U test). Highly significant elevations (P < 0.001)are highlighted in bold. Control samples not included in statistical analysis.

ISSN: 1471-2431