Table 3 Data from 2 patients diagnosed with ANE and 1 patient with highly suspected ANE
From: Seizures in febrile children with SARS-CoV-2 infection: clinical features, short-term follow-up
Variable | Patient 3 | Patient 4 | Patient 5 |
|---|---|---|---|
Sex | Female | Male | Male |
Age | 2 years and 2 months | 11 months | 2 months |
Main symptoms | Fever, seizures, impaired consciousness, double inspiration | Fever, seizures, impaired consciousness | Fever, seizures, impaired consciousness |
Seizure forms | GTCS | GTCS | GTCS |
Primary Diagnosis | ANE | ANE | Highly suspicious of ANE |
Cerebrospinal fluid | |||
WBC(*106/L) | None | 1 | 19 |
GLU(mmol/L) | None | 2.85 | 2.34 |
PRO(g/L) | None | 4.04 | 3.01 |
EBV(PCR) | None | Negative | Negative |
HSV(PCR) | None | Negative | Negative |
CMV(PCR) | None | Negative | Negative |
Cultivation | None | Negative | Negative |
mNGS | None | Negative | None |
Hematology tests | |||
WBC(*109/L) | 9.72 | 9.06 | 5.94 |
CRP(mg/L) | 10.51 | 17.66 | 0.71 |
PCT(ng/ml) | 38.23 | > 100 | 0.17 |
ALT(U/L) | 222 | 1307 | 32 |
AST(U/L) | 241 | 1970 | 48 |
SF(ng/ml) | 907.4 | None | None |
IL-6(pg/ml) | None | 109.1 | None |
CT or MRI of the head | The bilateral cerebellar hemispheres and thalamus exhibit symmetric patchy hypodense lesions. The density of the brainstem is reduced. In parts of the bilateral cerebral hemispheres, the grey-white matter differentiation is well-defined | Bilateral thalami, basal ganglia, brainstem, and cerebellum show symmetric large areas of hypodensity with partial swelling | The bilateral cerebral hemispheres demonstrate widespread hyperintense signals on both T1 and T2 weighted images. Similar signal abnormalities are observed in the bilateral thalamus, internal capsule, and brainstem |
Main treatment ventilator | |||
Drugs | Invasive ventilator | Invasive ventilator | None |
Methylprednisolone | Methylprednisolone | Methylprednisolone | |
Gammaglobulin | Gammaglobulin | Gammaglobulin | |