CNS status | Diagnostic criteria |
---|---|
CNS1 | CSF detection showed no leukemic cells and no abnormal clinical and imaging changes. |
CNS2 | a. Cerebrospinal fluid leukocytes < 5 cells/µl, blasts identified through CM in the centrifuged specimen; b. Flow cytometry detected immature cells in the cerebrospinal fluid. |
CNS3/CNSL | a. Cerebrospinal fluid leukocytes ≥ 5 cells/µL and blasts were found through CM in the centrifuged specimen; b. Have definite symptoms and signs of central nervous system involvement, such as cranial nerve paralysis that other causes cannot explain; c. Imaging evidence of central nervous system infiltration. |
TLP | Bloody cerebrospinal fluid or cerebrospinal fluid red blood cells ≥ 10/µL. |