Skip to main content

Table 2 Antibiotic use in the baseline and postintervention periods

From: Antibiotic use in infants at risk of early-onset sepsis: results from a unicentric retrospective cohort study

Measures

Baseline

n = 71

Postintervention

n = 66

Incidence rate difference

95% CI

Relative difference

%

p value

 

DOTs total

887.3

333

    

DOT total/1000 PDs

63

25.8

37.1 (32.1–42)

59.1

< 0.001

 

DOTs ampicillin

DOTs ampicillin/1000 PDs

432.3

30.68

157.1

12.18

18.5 (15–22)

60.3

< 0.001

 

DOTs gentamicin

DOTs gentamicin/1000 PDs

439

31.1

168

13

18.1 (14.5–21.6)

58.1

< 0.001

 

DOTs cephotaxime

DOTs cephotaxime/1000 PDs

16

1.1

7.8

0.6

0.5 (0.19–1.2)

45.4

0.08

 

AUR (%)

3.2

1.3

1.9 (1.6–2.3)

59.3

< 0.001

 

ASI/LOT, median (IQR)

7.0 (6.3–7.0)

7.0 (6.7–7.0)

-

 

0.87

 

LOT, days, median (IQR)

7 (6–7)

2.5 (2.0–3.0)

-

 

< 0.001

 
  1. DOTs, days of therapy; PDs, patient-days; AUR, antibiotic use rate; ASI, antibiotic spectrum index; LOT, length of therapy; IQR, interquartile range.