The role of nutrition in analysis of risk factors and short-term outcomes for late-onset necrotizing enterocolitis among very preterm infants: a nationwide, multicenter study in China

Table 5 Multivariate logistic regression analysis of LO-NEC for short-term outcomes in VPIs

Outcomes	LO-NEC (n = 212)	non-LO-NEC (n = 2297)	OR^a (95% CI)	P
LOS	53 (25.0)	270 (11.8)	1.527 (1.049 ~ 2.221)	0.027
Moderate and severe BPD	37 (17.5)	363 (15.8)	0.654 (0.420 ~ 1.020)	0.061
ROP requiring intervention	9 (4.2)	70 (3.0)	1.122 (0.517 ~ 2.432)	0.771
IVH (grade 3 or 4)	2 (0.9)	48 (2.1)	0.405 (0.096 ~ 1.716)	0.220
PVL	9 (4.2)	84 (3.7)	1.200 (0.579 ~ 2.488)	0.624
MBDP	13 (6.1)	57 (2.5)	2.613 (1.363 ~ 5.008)	0.004
PNAC	53 (25.0)	205 (8.9)	2.350 (1.616 ~ 3.416)	< 0.001
EUGR	135 (63.7)	1050 (45.7)	1.613 (1.114 ~ 2.337)	0.011

LOS Late-onset sepsis, BPD Bronchopulmonary dysplasia, ROP Retinopathy of prematurity, IVH Intraventricular hemorrhage, PVL Periventricular leukomalacia, MBDP Metabolic bone disease of prematurity, PNAC Parenteral nutrition associated cholestasis, EUGR Extrauterine growth restriction, SGA Small for gestational age, PN Parenteral nutrition, NRDS Neonatal respiratory distress syndrome, IMV Invasive mechanical ventilation
^aAdjusted for gestational age, birth weight, SGA, antenatal steroids, breastfeeding, duration of PN, grade III-IV NRDS, anemia,IMV, antibiotics

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