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Table 3 Summary of drug exposure

From: A multicenter, randomized, open-label, active-comparator trial to determine the efficacy, safety, and pharmacokinetics of intravenous ibuprofen for treatment of fever in hospitalized pediatric patients

 

Acetaminophen

Intravenous ibuprofen

N = 53

N = 47

Total Number of Doses

 Mean (SD)

4 (3.8)

4 (3.7)

 Median

1

4

 Min, Max

1, 17

1, 23

 1 Dose

28 (53%)

14 (30%)

 2 Doses

3 (6%)

8 (17%)

 3 Doses

2 (4%)

1 (2%)

 4 Doses

1 (2%)

1 (2%)

 5 Doses

1 (2%)

6 (13%)

 6 Doses

9 (17%)

11 (23%)

 > 6 Doses

9 (17%)

6 (13%)

Duration of Study Drug (hours)a

 Mean (SD)

15.4 (24.4)

16.6 (19.8)

 Median

0.0

16.0

 Min, Max

0.0, 117.5

0.0, 104.9

  1. N number, SD standard deviation, Min Minimum, Max Maximum
  2. aDuration of study drug is defined as the number of hours from the first dose to the last dose