Table 1 Summary of published hypothermia trials, showing effect size
Name of trial | Number in trial | Primary outcome and main secondary outcome | Effect size [assumed for TOBY] |
|---|---|---|---|
Cool cap trial | 218 | Death or severe impairment at 18 months | RR 0.82 95%CI 0.66–1.02 |
NICHD Trial | 208 | Death or any impairment at 18 months | RR 0.73 95%CI 0.56–0.95 |
Eicher | 65 | Death or severe impairment at 12 months | RR 0.62 95%CI 0.41–0.92 |
TOBY | 236 | Death or severe impairment at 18 months | [RR 0.70] |