Clinical presentation and outcome of Tuberculosis in Human Immunodeficiency Virus infected children on anti-retroviral therapy

Table 5 Reasons for changing the TB treatment regimen in episodes treated initially with standard or expanded regimens

Reason for regimen change	Initial regimen		Total (%)
	HRZ*	HRZ ± Eth ± E*
Persistent culture-positive/progressive disease	10	2	12 (38)
Drug resistance	3	4	7 (22)
Adverse event^#	3	6	9 (28)
M. bovis BCG/NTM**	3	1	4 (12)
Total (%)^##	19 (59)	13 (41)	32 (100)

*H = isoniazid, R = rifampicin, Z = pyrazinamide, Eth = ethionamide, E = ethambutol,
**M. bovis BCG = Mycobacterium bovis Bacillus Calmette-Guérin disease, NTM = non-tuberculous mycobacteria disease
^#In total there were 13 adverse events, only 9 appear in this table as the others did not necessitate a regimen change (2 started on alternative TB regimens, 1 stayed on the initial regimen, 1 had all treatment suspended)
^##In total 32 regimen changes were recorded in 29 cases; 3 changed regimens twice

ISSN: 1471-2431