Table 1 History of the most severe diarrhea events caused by microbial infections of intestine of the MPS I patient
Age of the patienta | Detected pathogenic microbial strain(s) | Antimicrobial agent(s) used | Special remarks |
|---|---|---|---|
11 months | E. coli (group C) | Trimethoprim and sulphamethoxazole | Severe diarrhea and vomiting, metabolic acidosis, hospitalization and i.v. rehydration required |
21 months (1 y. 9 mo.) | E. coli (group C) | Cefuroxime | Initially applied trimethoprim and sulphamethoxazole did not give a therapeutic effect |
27 months (2 y. 3 mo.) | E. coli (group A) | Nifuroxazide | None |
28 months (2 y. 4 mo.) | P. aeruginosa | None | Tablets containing Lactobacillus rhamnosus were used to normalize intestinal flora |
29 months (2 y. 5 mo.) | E. coli (group C) | Furazidin | None |
45 months (3 y. 9 mo.) | Adenoviruses, C. albicans (in addition, H. parainfluenzae, S. viridans and Neiserria sp. were isolated from oral cavity) | Cefuroxime, fluconazole, trimethoprim and sulphamethoxazole | Very severe diarrhea and vomiting, severe dehydration and electrolyte depletion, metabolic acidosis, severe stomatitis. Hospitalization and parenteral nutrition required |
49 months (4 y. 1 mo.) | Adenoviruses | None | None |
50 months (4 y. 2 mo.) | E. coli (group C) | Furazidin, trimethoprim and sulphamethoxazole | Severe diarrhea, hospitalization and i.v. rehydration required |
54 months (4 y. 6 mo.) | Adenoviruses | None | None |
55 months (4 y. 7 mo.) | E. coli (group C) | Furazidin | None |
56 months (4 y. 8 mo.) | E. coli (group C), S. aureus, C. albicans | Furazidin, fluconazole | None |