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Table 2 Risk factors for recurrent wheezing in the fifth year of life using logistic regression*

From: Persistent recurring wheezing in the fifth year of life after laboratory-confirmed, medically attended respiratory syncytial virus infection in infancy

 

Beta

Adjusted odds ratio

95% CI

PValue

Sex

    

 Male

0.40

1.49

1.39–1.60

<.0001

 Female

reference

   

Race

    

 White

reference

   

 African-American

0.53

1.71

1.52–1.91

<.0001

 Asian

0.31

1.36

1.24–1.49

<.0001

 Hispanic

0.10

1.11

1.01–1.22

0.0356

 Other/unknown

0.22

1.25

1.09–1.44

0.0020

Maternal age, y

    

 <18

-0.07

0.94

0.69–1.28

0.6764

 18–34

reference

   

 ≥35

0.04

1.04

0.96–1.13

0.3321

Family history of asthma

    

 Unknown

reference

   

 Father only

0.59

1.81

1.44–2.27

<.0001

 Mother only

0.76

2.15

1.87–2.47

<.0001

 Both parents

0.53

1.70

0.61–4.71

0.3109

Siblings <5 y of age in house

    

 None

reference

   

 ≥1

-0.15

0.86

0.80–0.92

<.0001

Congenital anomaly

    

 Present

0.13

1.14

1.00-1.29

0.0493

 Absent

reference

   

Small for gestational age

    

 No

reference

   

 Yes

-0.04

0.96

0.72–1.28

0.7822

Gestational age, wk

    

 32–33

0.40

1.49

1.15–1.92

0.0022

 34–36

0.26

1.30

1.14–1.48

<.0001

 37

0.11

1.12

0.98–1.29

0.1049

 38–40

reference

   

 ≥41

-0.06

0.95

0.85–1.05

0.2717

Oxygen exposure and BPD

    

 No oxygen exposure, no BPD

reference

   

 <200 hours oxygen, no BPD

0.28

1.32

1.12–1.57

0.0012

 ≥200 hours oxygen, no BPD

0.69

2.00

1.37–2.90

0.0003

 BPD

1.03

2.80

1.31–5.98

0.0078

Unspecified respiratory hospitalization

    

 None

reference

   

 Uncomplicated hospitalization

0.50

1.65

0.98–2.79

0.0594

 Prolonged hospitalization

1.24

3.46

1.94–6.16

<.0001

Laboratory-confirmed, medically attended RSV infection

    

 None

reference

   

 Outpatient visit only

0.32

1.38

1.03–1.85

0.0307

 Uncomplicated hospitalization

0.68

1.98

1.39–2.81

0.0002

 Prolonged hospitalization

0.95

2.59

1.49–4.50

0.0007

Laboratory-confirmed, medically attended infection with other pathogen

    

 None

reference

   

 Outpatient visit only

0.26

1.30

0.62–0.69

0.4883

 Uncomplicated hospitalization

0.32

1.38

0.54–3.52

0.4981

 Prolonged hospitalization

0.74

2.10

0.76–5.80

0.1526

  1. Abbreviations: BPD Bronchopulmonary dysplasia, CI Confidence interval, RSV Respiratory syncytial virus, wk week, y year.
  2. *Based on study cohort of 72,602 children, of whom 3380 had recurrent wheezing in the fifth year of life. See text for description of cohort and definition of recurrent wheezing. Results have been adjusting for infant and mother demographic and clinical characteristics.
  3. Please refer to the appropriate section of the footnotes to Table 2 for further details.
  4. Percent adherence to recommended course per AAP guidelines, see online appendix for details of how adherence was calculated.