Table 4 Comparison of abnormal values of diagnostic markers between ALL and JIA patients
Diagnostic markers | All patients n/N (%) | ALL n/N (%) | JIA n/N (%) | p-value (ALL versus JIA) | Sensitivity | Specificity | PPV | NPV | LR+ | LR- |
|---|---|---|---|---|---|---|---|---|---|---|
WBC count | 59/113 (52.2) | 26/45 (57.8) | 33/68 (48.5) | 0.345 | ||||||
Neutrophil count | 23/101 (22.8) | 21/40 (52.5) | 2/61 (3.3) | 0.000 | 52.5% | 96.7% | 91.3% | 75.6% | 15.9 | 0.5 |
Platelet count | 87/113 (77.0) | 36/45 (80.0) | 51/68 (75) | 0.650 | ||||||
Hb | 32/113 (28.3) | 26/45 (57.8) | 6/68 (8.8) | 0.000 | 57.8% | 91.2% | 81.2% | 76.5% | 6.6 | 0.5 |
LDH | 70/92 (76.1) | 37/43 (86.0) | 33/49 (67.3) | 0.050 | ||||||
ESR | 78/95 (82.1) | 24/27 (88.9) | 54/68 (79.4) | 0.379 | ||||||
CRP | 73/99 (73.7) | 26/38 (68.4) | 47/61 (77.0) | 0.358 | ||||||
ANA | 34/76 (44.7) | 2/14 (14.3) | 32/62 (51.6) | 0.016 | 14.3% | 48.4% | 5.8% | 71.4% | 0.3 | 1.8 |
IgG | 34/96 (35.4) | 12/39 (30.8) | 22/57 (38.6) | 0.517 | ||||||
IgM | 6/96 (6.3) | 2/39 (5.1) | 4/5 (7.0) | 1.000 | ||||||
IgA | 23/96 (24.0) | 15/39 (38.5) | 8/57 (14.0) | 0.008 | 38.5% | 86% | 65.2% | 67.1% | 2.8 | 0.7 |
C3 | 42/82 (51.2) | 17/28 (60.7) | 25/54 (46.3) | 0.250 | ||||||
C4 | 23/81 (18.4) | 14/28 (50.0) | 9/53 (17.0) | 0.004 | 50% | 83% | 60.8% | 75.8% | 2.9 | 0.6 |
Anti-EBV IgM | 8/50 (16.0) | 7/36 (19.4) | 1/14 (7.1) | 0.414 | ||||||
Anti-EBV IgG | 35/51 (68.6) | 27/36 (75.0) | 8/15 (53.3) | 0.187 | ||||||
Anti-EA EBV IgG | 12/40 (30.0) | 12/30 (40.0) | 0/10 (0) | 0.019 | 40.0% | 100% | 1.0% | 35.7% | - | 0.6 |
Anti-CMV IgM | 4/40 (10.0) | 2/30 (6.7) | 2/10 (20.0) | 0.256 | ||||||
Anti-CMV IgG | 24/39 (61.5) | 22/29 (75.9) | 2/10 (20.0) | 0.003 | 75.9% | 80.0% | 91.6% | 53.3% | 3.8 | 0.3 |