Group 1 | Group 2 | Group 3 | p-value* | |
---|---|---|---|---|
(1997–2000) | (2001–2005) | (2006–2009) | ||
(N = 65) | (N = 178) | (N = 172) | ||
CRIB | 3 (1–8) | 4 (2–7) | 4 (2–8) | 0.722 |
RDS | 36 (55.4%) | 99 (55.6%) | 103 (59.9%) | 0.432 |
Sepsis | 28 (43.1%) | 85 (47.8%) | 65 (37.8%) | 0.215 |
NEC | 6 (9.2%) | 12 (6.7%) | 12 (7.0%) | 0.644 |
IVH | 18 (27.7%) | 36 (20.2%) | 43 (25.0%) | 0.999 |
- Grades III/IV | 11 (16.9%) | 16 (9.0%) | 18 (10.5%) | 0.307 |
PVLM | 1 (4.5%) | 5 (5.6%) | 4 (2.3%) | 0.245 |
PDA | 17 (26.2%) | 56 (31.5%) | 75 (43.6%) | 0.004 |
- Surgical closure | 1 (1.5%) | 12 (6.7%) | 18 (10.5%) | 0.058 |
Parenteral nutrition (day) | 13 (7–20) | 9 (6–13) | 8 (6–12) | 0.009 |
Formula feed | 24 (45.3%) | 40 (25.2%) | 17 (11.1%) | <0.001 |
Mortality** | 23 (35.4%) | 43 (24.2%) | 40 (23.3%) | 0.102 |
SWsBPD | 38 (58.5%) | 132 (74.2%) | 129 (75.0%) | 0.032 |
In survivors: | n = 42 | n = 135 | n = 132 | |
Mild BPD | 8 (19.0%) | 34 (25.2%) | 39 (29.5%) | 0.378 |
Moderate or severe BPD | 4 (9.5%) | 3 (2.2%) | 3 (2.3%) | 0.046 |
Weight at discharge (g) | 2148 (2100–2250) | 2060 (1900–2160) | 2013 (1900–2193) | <0.001 |
Length of stay (days) | 83 (64–102) | 70 (59–83) | 71 (59–85) | 0.007 |
Weight gain (g/kg/day) | 16 (14–18) | 17 (15–19) | 17 (15–19) | 0.233 |