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Table 3 Outcome prediction at birth: uni- and multivariate association of clinical and demographic parameters known at birth with mortality, adverse outcome and unfavourable outcome

From: Outcome at two years of age in a Swiss national cohort of extremely preterm infants born between 2000 and 2008

MORTALITY

Univariate model†

 

Multivariate model‡

 
 

OR (95%-CI)

p-value

OR (95%-CI)

p-value

Gestational age (weeks)

0.39 (0.34 - 0.44)

<0.001

0.40 (0.35 - 0.47)

<0.001

BW z-score

0.64 (0.56 - 0.74)

<0.001

NA

 

BW z-score < −2

6.99 (3.09 - 15.85)

<0.001

11.68 (4.73 - 28.86)

<0.001

BW z-score −2 to −1

2.10 (1.46 - 3.03)

<0.001

2.71 (11.78 - 4.12)

<0.001

Male sex

1.06 (0.82 - 1.35)

0.67

1.15 (0.86 - 1.54)

0.33

Outborn

0.80 (0.45 - 1.45)

0.47

NA

 

Antenatal corticosteroids

0.34 (0.26 - 0.44)

<0.001

0.46 (0.34 - 0.62)

<0.001

Caesarean delivery

0.49 (0.37 - 0.65)

<0.001

NA

 

Multiple pregnancy

1.02 (0.77 - 1.34)

0.90

1.27 (0.91 - 1.78)

0.16

ADVERSE OUTCOME

Univariate model†

 

Multivariate model‡

 
 

OR (95%-CI)

p-value

OR (95%-CI)

p-value

Gestational age (weeks)

0.47 (0.41 - 0.53)

<0.001

0.49 (0.42 - 0.56)

<0.001

BW z-score

0.71 (0.62 - 0.88)

<0.001

NA

 

BW z-score < −2

5.36 (2.22 - 12.90)

<0.001

7.90 (3.08 - 20.25)

<0.001

BW z-score −2 to −1

1.91 (1.32 - 2.78)

<0.001

2.35 (1.59 - 3.55)

<0.001

Male sex

1.20 (0.94 - 1.54)

0.15

1.34 (1.01 - 1.77)

0.042

Outborn

0.98 (0.53 - 1.81)

0.95

NA

 

Antenatal corticosteroids

0.40 (0.31 - 0.53)

<0.001

0.51 (0.38 - 0.69)

<0.001

Caesarean delivery

0.53 (0.39 - 0.70)

<0.001

NA

 

Multiple pregnancy

0.96 (0.73 - 1.27)

0.80

1.19 (0.87 - 1.64)

0.28

UNFAVOURABLE OUTCOME

Univariate model†

 

Multivariate model‡

 
 

OR (95%-CI)

p-value

OR (95%-CI)

p-value

Gestational age (weeks)

0.52 (0.45 - 0.59)

<0.001

0.54 (0.47 - 0.61)

<0.001

BW z-score

0.73 (0.63 - 0.85)

<0.001

NA

 

BW z-score < −2

12.05 (2.82 - 51.48)

<0.001

16.91 (3.84 - 74.47)

<0.001

BW z-score −2 to −1

1.59 (1.08 - 2.33)

0.019

1.82 (1.20 - 2.74)

0.004

Male sex

1.24 (0.96 - 1.59)

0.09

1.35 (1.02 - 1.77)

0.033

Outborn

1.30 (0.68 - 2.49)

0.42

NA

 

Antenatal corticosteroids

0.48 (0.36 - 0.63)

<0.001

0.57 (0.43 - 0.77)

<0.001

Caesarean delivery

0.69 (0.51 - 0.93)

<0.001

NA

 

Multiple pregnancy

1.05 (0.79 - 1.38)

0.76

1.31 (0.96 - 1.78)

0.087

  1. The table gives all parameters that showed an unequal distribution among groups as shown in Table I or that are known from previous publications to act as confounders. † The univariate model is adjusted for study centre and year group. ‡ The multivariate model contains all parameters that were associated with the outcome in the univariate model.
  2. CI, confidence interval; OR, Odd’s ratio; BW, birth weight.
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BMC Pediatrics

ISSN: 1471-2431

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