Secondary outcome | Measurement |
---|---|
Serum/red cell folate levels | Measured using appropriate equipment (e.g. the Elecsys 2010 (Roche) or Immulite 2000) and reported in ng/ml. |
Recurrence and severity of CL/P | A severity score will be generated based on Table 6 above and the classification reported in Additional file 1 |
Occurrence of twinning | Greater than 1 fetus per current pregnancy |
Occurrence of a miscarriage/spontaneous abortion | Fetal loss before 20 weeks of pregnancy |
Incidence of Preeclampsia | As reported according to local obstetric standards |
Occurrence of other birth defects | As diagnosed by clinical exam. |
Birth Weight of the baby | As measured at birth (in grams) |
Gestational age at birth | As determined by the obstetrician (in weeks-days) |