Study | Intervention | Supplemented group | Control group | Reduction | ||
---|---|---|---|---|---|---|
# births | RR (%) | # births | RR (%) | |||
Conway (1958) | MV and 0.5mg FA | 59 | 0.0 | 78 | 6.4 | 100% (p=0.1) |
Peer et al. (1964) | MV and 5mg FA and 10mg B6 | 176 | 2.2 | 418 | 4.7 | 53% (p=0.1) |
Briggs 1976 [extension of Peer et al. (1964)] | MV and 5mg FA and 10mg B6 | 228 | 3.1 | 417 | 4.8 | 35% (p=0.2) |
Tolarova (1982) | MV and 10mg FA | 84 | 1.2 | 206 | 7.3 | 84% (p=0.02) |
Tolarova and Harris (1995) | MV and 10mg FA | 211 | 1.4 | 1824 | 4.2 | 66% (p=0.03) |
Total** | Â | 498 | 2.01 | 2319 | 4.38 | 54.1% |