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Table 8 ROC curve analysis statistics for combination of all 4 test measurements

From: A prospective study of the sensitivity, specificity and diagnostic performance of soluble intercellular adhesion molecule 1, highly sensitive C-reactive protein, soluble E-selectin and serum amyloid A in the diagnosis of neonatal infection

Infected

 

All

Early onset

Late onset

Preterm

Term

sICAM-1+hsCRP

+SAA+sE selectin

n = 62

n = 12

n = 50

n = 52

n = 10

AUC

0.84

0.72

0.74

0.84

0.78

sensitivity

90.3%

66.7%

66.0%

92.3%

60.0%

specificity

67.0%

87.3%

74.2%

69.2%

89.7%

Positive predictive value

64.4%

50.0%

80.5%

70.6%

66.7%

Negative predictive value

91.3%

93.2%

57.5%

91.8%

86.7%

Culture positive infection

 

All

Early onset

Late Onset

Preterm

Term

sICAM-1+hsCRP

+SAA+sE selectin

n = 33

n = 5

n = 28

n = 27

n = 6

AUC

0.84

0.82

0.75

0.87

0.63

sensitivity

84.8%

80.0%

50.0%

96.3%

33.3%

specificity

66.7%

82.9%

88.7%

65.6%

97.0%

Positive predictive value

40.6%

25.0%

70.0%

45.6%

66.7%

Negative predictive value

94.3%

98.3%

77.0%

98.3%

88.9%

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BMC Pediatrics

ISSN: 1471-2431

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