Articles
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Citation: BMC Pediatrics 2024 24:197
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Renal toxicity of ifosfamide in children with cancer: an exploratory study integrating aldehyde dehydrogenase enzymatic activity data and a wide-array urinary metabolomics approach
Ifosfamide is a major anti-cancer drug in children with well-known renal toxicity. Understanding the mechanisms underlying this toxicity could help identify children at increased risk of toxicity.
Citation: BMC Pediatrics 2024 24:196 -
Social withdrawal behaviour in Nepalese infants and the relationship with future neurodevelopment; a longitudinal cohort study
Social withdrawal in infants may be a signal of distress and a precursor for non-optimal development.
Citation: BMC Pediatrics 2024 24:195 -
Infantile-onset pompe disease: a case report emphasizing the role of genetic counseling and prenatal testing
Pompe disease, classified as glycogen storage disease type II, arises from a deficiency in the acid alpha-glucosidase (GAA) enzyme, leading to glycogen accumulation in multiple tissues. The unique correlation ...
Citation: BMC Pediatrics 2024 24:194 -
Gut microbiota profiling in obese children from Southeastern China
Childhood obesity not only has a negative impact on a child's health but is also a significant risk factor for adult obesity and related metabolic disorders, making it a major global public health concern. Rec...
Citation: BMC Pediatrics 2024 24:193 -
Proportion of vitamin D deficiency in children/adolescents with type 1 diabetes: a systematic review and meta-analysis
The impact of vitamin D on type 1 diabetes has been a controversial topic in public health. Furthermore, significant differences in the proportion of vitamin D have been noted. The purpose of this systematic r...
Citation: BMC Pediatrics 2024 24:192 -
The assessment of preschool children with ESSENCE symptoms: concordance between parents, preschool teachers and child psychologists
It is important to detect children with Early Symptomatic Syndromes Eliciting Neurodevelopmental Clinical Examinations (ESSENCE) in order to implement early intervention and support for the child and family. S...
Citation: BMC Pediatrics 2024 24:191 -
NLRC4 methylation and its response to intravenous immunoglobulin therapy in Kawasaki disease: a case control study
Kawasaki disease (KD) is a systemic vasculitis accompanied by many systemic physiological and biochemical changes. Elucidating its molecular mechanisms is crucial for diagnosing and developing effective treatm...
Citation: BMC Pediatrics 2024 24:190 -
Aberrant SOX10 and RET expressions in patients with Hirschsprung disease
HSCR is a complex genetic disorder characterized by the absence of ganglion cells in the intestine, leading to a functional obstruction. It is due to a disruption of complex signaling pathways within the gene ...
Citation: BMC Pediatrics 2024 24:189 -
Awareness and healthcare seeking behavior of neonatal danger signs, and predictor variables among mothers/caregivers in four developing regional state of Ethiopia
: Mothers/caregivers should be aware of a newborn’s danger signs and promptly seek medical attention. Hence, this study assessed mothers’/caregivers’ awareness, healthcare seeking behaviors for neonatal danger...
Citation: BMC Pediatrics 2024 24:188 -
Postnatal care and acceptability of emollient therapy in very low birthweight infants in Harare, Zimbabwe: a qualitative analysis
Preterm birth (birth before 37 completed weeks of pregnancy) is the leading cause of neonatal and child under-five mortality globally, both of which are highest regionally in sub-Saharan Africa. The skin barri...
Citation: BMC Pediatrics 2024 24:187 -
Clinical features and treatment options for pediatric adrenal incidentalomas: a retrospective single center study
The aim of this study was to investigate the clinical features and treatment options for pediatric adrenal incidentalomas(AIs) to guide the diagnosis and treatment of these tumors.
Citation: BMC Pediatrics 2024 24:186 -
Relationship between vitamin D levels and pediatric celiac disease: a systematic review and meta-analysis
The relationship between Vitamin D levels and pediatric celiac disease (CD) remains controversial. In this study, we conducted a systematic review and meta-analysis to examine the relationship between Vitamin ...
Citation: BMC Pediatrics 2024 24:185 -
The footprint of SARS-COV-2 infection in neonatal late sepsis
Predicting and finding the viral agents responsible for neonatal late-sepsis has always been challenging.
Citation: BMC Pediatrics 2024 24:184 -
Values of serum intestinal fatty acid-binding protein, fecal calprotectin, and fecal human β-defensin 2 for predicting necrotizing enterocolitis
This study aimed to assess the diagnostic potential of serum intestinal fatty acid-binding protein (I-FABP), fecal calprotectin (FC), and fecal human β-defensin 2 (hBD2) in predicting necrotizing enterocolitis...
Citation: BMC Pediatrics 2024 24:183 -
Novel PIP5K1C variant identified in a Chinese pedigree with lethal congenital contractural syndrome 3
Biallelic pathogenic variants in PIP5K1C (MIM #606,102) lead to lethal congenital contractural syndrome 3 (LCCS3, MIM #611,369), a rare autosomal recessive genetic disorder characterized by small gestational age,...
Citation: BMC Pediatrics 2024 24:182 -
Persian version of brief infant sleep questionnaire (BISQ): a psychometric evaluation
The high prevalence of sleep problems and their negative consequences on children and parents highlight the need to design early screening instruments to evaluate sleep problems in early childhood. We aimed to...
Citation: BMC Pediatrics 2024 24:181 -
Diabetes-related instrument to assess preventive behaviors among adolescents (DIAPBA): a tool development and psychometric research
Type 2 diabetes is a chronic but preventable disease that is on the rise among adolescents. Evaluating adolescents’ behavior and planning to prevent it require a valid and reliable instrument. This study aims ...
Citation: BMC Pediatrics 2024 24:180 -
Multisystem inflammatory syndrome in children (MIS-C) post-COVID-19 in Iran: clinical profile, cardiac features, and outcomes
In April 2020, an association between multisystem inflammatory syndromes (MIS-C) was observed in children with severe acute respiratory syndrome coronavirus infection (SARS-CoV-2). Most patients had heart invo...
Citation: BMC Pediatrics 2024 24:179 -
Correlation analysis between the amniotic fluid contamination and clinical grading of neonatal hypoxic–ischemic encephalopathy and biomarkers of brain damage
Amniotic fluid contamination (AFC) is a risk factor for neonatal hypoxic ischemic encephalopathy (HIE); however, the correlation between AFC level and the incidence and clinical grading of HIE, in addition to ...
Citation: BMC Pediatrics 2024 24:178 -
Use of antimicrobials in pediatric wards of five Brazilian hospitals
The use of antimicrobials (AMs) in pediatric infections is common practice and use may be inappropriate leading to antimicrobial resistance. Off-label AM use is also common in this group and can result in drug...
Citation: BMC Pediatrics 2024 24:177 -
Quantifying health facility service readiness for small and sick newborn care: comparing standards-based and WHO level-2 + scoring for 64 hospitals implementing with NEST360 in Kenya, Malawi, Nigeria, and Tanzania
Service readiness tools are important for assessing hospital capacity to provide quality small and sick newborn care (SSNC). Lack of summary scoring approaches for SSNC service readiness means we are unable to...
Citation: BMC Pediatrics 2024 23(Suppl 2):656 -
The association of dietary carbohydrate quality and quantity with obesity among Iranian adolescents: a case-control study
Adolescent obesity is considered as a major health concern worldwide which is closely linked to the quality of diet. The purpose of the present study was to assess the carbohydrate quality and quantity in rela...
Citation: BMC Pediatrics 2024 24:176 -
Primary-school-aged children inspire their peers and families to eat more vegetables in the KiiDSAY project: a qualitative descriptive study
While vegetable intakes in Australia remain sub-optimal across all age groups, children are rarely consulted about their ideas on how to increase consumption. Qualitative research involving children provides a...
Citation: BMC Pediatrics 2024 24:175 -
Study protocol for the ACTIVE SCHOOL study investigating two different strategies of physical activity to improve academic performance in Schoolchildren
Previous research has suggested that school-based physical activity (PA) interventions may have a positive impact on academic performance. However, existing literature on school-based interventions encompasses...
Citation: BMC Pediatrics 2024 24:174 -
Vacuum bell therapy for pectus excavatum: a retrospective study
Pectus excavatum, the most common chest wall deformity, is frequently treated with Nuss procedure. Here we will describe non-invasive procedure and analyze the variables associated vacuum bell therapy for pati...
Citation: BMC Pediatrics 2024 24:173 -
The role of nutrition in analysis of risk factors and short-term outcomes for late-onset necrotizing enterocolitis among very preterm infants: a nationwide, multicenter study in China
Necrotizing enterocolitis (NEC) is a serious gastrointestinal disease, primarily affects preterm newborns and occurs after 7 days of life (late-onset NEC, LO-NEC). Unfortunately, over the past several decades,...
Citation: BMC Pediatrics 2024 24:172 -
Effect of early preventive supplementation with calcium and phosphorus on metabolic bone disease in premature infants
The objective was to study the effect of early preventive calcium and phosphorus supplementation on metabolic bone disease in preterm infants.
Citation: BMC Pediatrics 2024 24:171 -
Mortality and associated factors among children admitted to an intensive care unit in muhimbili national hospital, from the time of admission to three months after discharge: a prospective cohort study
Mortality of children admitted to Intensive Care Units (ICU) is higher in low-to-middle-income countries (LMICs) as compared to high-income countries (HICs). There is paucity of information on outcomes followi...
Citation: BMC Pediatrics 2024 24:170 -
Association between textual and pictorial warnings on tumbac (waterpipe tobacco) boxes and motivation to quit waterpipe smoking among Lebanese and Iraqi adolescents
Waterpipe tobacco smoking has increased tremendously at a global level among all age groups, particularly young people. Previous studies have examined the impact of waterpipe tobacco pictorial health warnings ...
Citation: BMC Pediatrics 2024 24:169 -
Population-based cross-sectional study of factors influencing full vaccination status of children aged 12- 23 months in a rural district of the Upper East Region, Ghana
Achieving universal health coverage includes ensuring that children have access to vaccines that are of high quality, safe, efficacious, and affordable. The Immunisation Agenda 2030 aims to expand services to ...
Citation: BMC Pediatrics 2024 24:168 -
Association between parental feeding styles, body mass index, and consumption of fruits, vegetables and processed foods with mothers´ perceptions of feeding difficulties in children
Feeding difficulties (FDs) are complex phenomena influenced by parental factors, feeding behaviour, and cultural factors. However, studies of the influences of these factors on FDs incidence are scarce. Thus, ...
Citation: BMC Pediatrics 2024 24:167 -
The first pineoblastoma case report of a patient with Sotos syndrome harboring NSD1 germline mutation
Germline mutations of NSD1 are associated with Sotos syndrome, characterized by distinctive facial features, overgrowth, and developmental delay. Approximately 3% of individuals with Sotos syndrome develop tumors...
Citation: BMC Pediatrics 2024 24:166 -
Parental engagement in research on paediatric lower respiratory tract infections in Indonesia
Lower respiratory tract infections (LRTIs) in children are a major concern in Indonesia as it is the leading cause of morbidity and mortality. Therefore, research on LRTIs is crucial to improve children’s heal...
Citation: BMC Pediatrics 2024 24:165 -
Movement behaviour education for parents in prenatal, postnatal, and pediatric care in Canada: A needs assessment
Parents/guardians can greatly influence their child’s movement behaviours (i.e., physical activity, sedentary behaviour, and sleep). Yet, they have reported to lack sufficient background knowledge to foster he...
Citation: BMC Pediatrics 2024 24:164 -
Health-related quality of life and self-reported health status in adolescents with chronic health conditions before transfer of care to adult health care: an international cohort study
Heath-related quality of life (HRQoL) is lower in adolescents with chronic health conditions compared to healthy peers. While there is evidence of some differences according to the underlying condition and gen...
Citation: BMC Pediatrics 2024 24:163 -
Health facility assessment of small and sick newborn care in low- and middle-income countries: systematic tool development and operationalisation with NEST360 and UNICEF
Each year an estimated 2.3 million newborns die in the first 28 days of life. Most of these deaths are preventable, and high-quality neonatal care is fundamental for surviving and thriving. Service readiness i...
Citation: BMC Pediatrics 2024 23(Suppl 2):655 -
Clinical characteristics and prognoses in pediatric neuroblastoma with bone or liver metastasis: data from the SEER 2010–2019
To investigate clinical characteristics, prognoses, and impacts of treatments on prognoses of neuroblastoma patients with bone or liver metastasis.
Citation: BMC Pediatrics 2024 24:162 -
Importance about use of high-throughput sequencing in pediatric: case report of a patient with Fanconi-Bickel syndrome
Fanconi-Bickel syndrome is characterized by hepatorenal disease caused by anomalous glycogen storage. It occurs due to variants in the SLC2A2 gene. We present a male patient of 2 years 7 months old, with failure ...
Citation: BMC Pediatrics 2024 24:161 -
Novel CAD gene mutations in a boy with developmental and epileptic encephalopathy 50 with dramatic response to uridine therapy: a case report and a review of the literature
Developmental and epileptic encephalopathy-50 (DEE-50) is a rare clinical condition believed to be caused by a mutation in the CAD gene and is associated with a bleak prognosis. CAD-related diseases have a wide r...
Citation: BMC Pediatrics 2024 24:160 -
Associations of sleep time, quality of life, and obesity indicators on physical literacy components: a structural equation model
To verify the association between ideal sleep time and physical literacy components while also considering multiple mediators, such as quality of life and obesity, using a sample of adolescents.
Citation: BMC Pediatrics 2024 24:159 -
Prediction of coronary artery lesions in children with Kawasaki syndrome based on machine learning
Kawasaki syndrome (KS) is an acute vasculitis that affects children < 5 years of age and leads to coronary artery lesions (CAL) in about 20-25% of untreated cases. Machine learning (ML) is a branch of artifici...
Citation: BMC Pediatrics 2024 24:158 -
Relationship between chorioamnionitis or funisitis and lung injury among preterm infants: meta-analysis involved 16 observational studies with 68,397 participants
Chorioamnionitis (CA) can cause multiple organ injuries in premature neonates, particularly to the lungs. Different opinions exist regarding the impact of intrauterine inflammation on neonatal respiratory dist...
Citation: BMC Pediatrics 2024 24:157 -
Influenza a H1N1 infection complicated with encephalopathy and acute pancreatitis: a case report
This paper reports a case of influenza complicated with influenza associated encephalopathy complicated with acute pancreatitis. This kind of disease is relatively rare, we hope to draw people’s attention to i...
Citation: BMC Pediatrics 2024 24:156 -
The effect of oropharyngeal mother’s milk on nutritional outcomes in preterm infants: a randomized controlled trial
Oropharyngeal interventions are an accepted method to improve the nutritional performance of premature infants. Considering the countless benefits of breast milk and the few studies on the use of breast milk a...
Citation: BMC Pediatrics 2024 24:155 -
The response of CD27+CD38+ plasmablasts, CD24hiCD38hi transitional B cells, CXCR5−ICOS+PD-1+ Tph, Tph2 and Tfh2 subtypes to allergens in children with allergic asthma
Allergic asthma is a type I allergic reaction mediated by serum Immunoglobulin E (IgE). B cell-mediated humoral immune response to allergens in the pathophysiology of allergic asthma have not been thoroughly e...
Citation: BMC Pediatrics 2024 24:154 -
Risk factors of multidrug-resistant organisms neonatal sepsis in Surabaya tertiary referral hospital: a single-center study
Bacterial organisms causing neonatal sepsis have developed increased resistance to commonly used antibiotics. Antimicrobial resistance is a major global health problem. The spread of Multidrug-Resistant Organi...
Citation: BMC Pediatrics 2024 24:153 -
The impact of blood lactic acid levels on retinopathy of prematurity morbidity
Retinopathy of prematurity (ROP) is a common disease in premature infants. In recent years, most researchers have used lactic acid as poor prognosis marker in premature infants. This study aims to explore inve...
Citation: BMC Pediatrics 2024 24:152 -
Individualized estimation of arterial carbon dioxide partial pressure using machine learning in children receiving mechanical ventilation
Measuring arterial partial pressure of carbon dioxide (PaCO2) is crucial for proper mechanical ventilation, but the current sampling method is invasive. End-tidal carbon dioxide (EtCO2) has been used as a surroga...
Citation: BMC Pediatrics 2024 24:149 -
Two cases of small bowel necrosis due to intussusception secondary to abnormal proliferation of intestinal Peyer’s patches in infants after MMR vaccination
Intussusception is one of the most common acute abdominal conditions in pediatric patients, and if left untreated, it may result in intestinal necrosis and even death. The etiology of the disease is unknown an...
Citation: BMC Pediatrics 2024 24:147
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