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Table 3 Logistic regression analysis of risk factors for NDI, EGR, and concurrent NDI and EGR in neonates with various medical conditions in the NICU

From: Sustained acute kidney injury as an independent risk factor for neurodevelopmental and growth outcomes in a single NICU center

 

Univariate

Multivariate

OR

95% CI

P value

OR

95% CI

P value

Neurodevelopmental impairment (NDI)

 1-min APGAR score a

0.192

0.094–0.391

< 0.001

0.440

0.146–1.324

0.144

 5-min APGAR score b

0.212

0.105–0.430

< 0.001

0.408

0.134–1.244

0.115

 Brain insult in the perinatal period

1.008

0.424–2.397

0.986

   

 Non-congenital urological anomalies

2.670

0.898–7.938

0.077

   

 SAKI

5.429

2.626–11.225

< 0.001

4.013

1.702–9.459

0.001*

 Needing RRT during AKI

6.259

1.645–23.805

0.007*

2.217

0.467–10.514

0.316

Early growth restriction (EGR)

 1-min APGAR score a

0.965

0.470–1.981

0.922

   

 5-min APGAR score b

1.038

0.506–2.131

0.919

   

 Brain insult in the perinatal period

0.415

0.134–1.284

0.127

   

 Non-congenital urological anomalies

1.329

0.427–4.141

0.624

   

 SAKI

6.117

2.844–13.157

< 0.001

4.894

2.133–11.229

< 0.001

 Needing RRT during AKI

7.081

2.050–24.454

0.002*

2.500

0.655–9.537

0.180

Simultaneous NDI and EGR

 1-min APGAR score a

0.678

0.298–1.546

0.356

   

 5-min APGAR score b

0.724

0.318–1.650

0.443

   

 Brain insult in the perinatal period #

0.327

0.073–1.473

0.145

   

 Non-congenital urological anomalies

1.742

0.511–5.937

0.375

   

 SAKI

6.021

2.550–15.083

< 0.001

4.821

1.832–12.681

0.001*

 Needing RRT during AKI

6.667

2.039–21.802

0.002*

2.528

0.698–9.157

0.158

  1. OR Odds ratio, CI Confidence interval
  2. *A P-value of < 0.05 is considered statistically significant
  3. aMedian number of 1-min APGAR score (7 point) used for logistic regression analysis
  4. bMedian number of 5-min APGAR score (9 point) used for logistic regression analysis
  5. #Perinatal asphyxia with or without resuscitation/with or without hypoxic ischemic encephalopathy