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Table 2 Comparisons of long-term neurodevelopmental and growth outcomes in neonates with SAKI episodes versus controls

From: Sustained acute kidney injury as an independent risk factor for neurodevelopmental and growth outcomes in a single NICU center

 

Total

(n = 154, 100%)

SAKI group

(n = 51, 33.1%)

Control group

(n = 103, 66.9%)

P value

Neurodevelopmental impairment, n (%)

59 (38.3%)

33 (64.7%)

26 (25.2%)

< 0.001

Bayley Scales of Infant and Toddler Development a

 Cognitive score (n/total)

91.0 ± 14.8 (85/154)

86.7 ± 13.2 (29/59)

93.4 ± 15.1 (56/103)

0.042*

 Language score (n/total)

87.1 ± 14.0 (85/154)

80.7 ± 12.4 (29/59)

90.1 ± 13.9 (56/103)

0.004*

 Motor score (n/total)

88.8 ± 17.0 (85/154)

82.8 ± 16.0 (29/59)

91.9 ± 16.8 (56/103)

0.019*

Cerebral palsy, n (%)

4 (2.6%)

3 (5.9%)

1 (1.0%)

0.072

Early growth restriction, n (%)

43 (27.9%)

27 (52.9%)

16 (15.5%)

< 0.001

Body height (cm)

 At the CA of 6 months

64.2 ± 3.7

62.3 ± 4.5

65.0 ± 2.9

< 0.001

 At the CA of 1 year

72.8 ± 3.6

70.9 ± 4.5

73.5 ± 2.9

< 0.001

 At the CA of 2 years

84.0 ± 4.6

81.6 ± 5.9

85.0 ± 3.7

0.001*

Body weight (kg)

 At the CA of 6 months

7.07 ± 1.22

6.45 ± 1.42

7.34 ± 1.02

< 0.001

 At the CA of 1 year

8.77 ± 1.53

7.85 ± 1.76

9.17 ± 1.23

< 0.001

 At the CA of 2 years

11.22 ± 1.72

10.12 ± 1.56

11.63 ± 1.60

< 0.001

Head circumference (cm)

 At the CA of 6 months

41.6 ± 1.9

40.5 ± 2.2

42.0 ± 1.6

< 0.001

 At the CA of 1 year

44.3 ± 4.1

43.5 ± 2.2

44.7 ± 4.6

0.148

 At the CA of 2 years

46.9 ± 2.0

45.8 ± 2.2

47.3 ± 1.8

0.003*

Simultaneous NDI and EGR, n (%)

15 (9.7%)

10 (19.6%)

5 (4.9%)

0.003*

Needing long-term RRT, n (%)

4 (5.2%)

4 (7.8%)

0 (0%)

0.004*

  1. Data are expressed as the mean ± standard deviation and a *P-value of < 0.05 is considered statistically significant
  2. aThird Edition (Bayley-III) in 18–24 months old