Posterior urethral valve in thai boys

Background Posterior urethral valve (PUV) is the most common congenital bladder outlet obstruction in boys, causing renal damage beginning in utero. There are scarce data from Thailand regarding the long-term outcomes of PUV in boys, thus the aim of this study was to examine the presentation, clinical course, complications, outcomes and renal survival in PUV boys. Methods We reviewed the medical records of PUV boys treated at the Pediatric Nephrology Clinic, Prince of Songkla University, Thailand, over a 30-year-period. Results Seventy-seven PUV boys were identified, with a median age at diagnosis of 4.8 months. The most common presentations were urinary tract infection (UTI), poor urine stream and urinary dribbling in 26 (33.8%), 19 (24.7%) and 11 (14.3%) boys, respectively. Renal ultrasound results in 70 boys showed 8 (11.4%) unilateral and 56 (80%) bilateral hydronephroses. Of 72 voiding cystourethrograms, 18 (25.0%) showed unilateral and 22 (30.6%) bilateral vesicoureteral refluxes. 99mTc dimercaptosuccinic acid renal scans in 30 boys showed 12 (40%) unilateral and 8 (26.7%) bilateral renal damage. Fifty-nine (76.6%) boys had 149 UTIs; 42 (54.4%) had recurrent UTI. Forty-eight boys had valve ablation at the median age of 30.3 months. 22 boys (28.6%) developed chronic kidney disease (CKD) at a median age of 15.0 years. Conclusion Of 77 PUV Thai boys, UTI was the most common presentation. Recurrence of UTI and CKD was the most common consequence. Lifelong follow-up for renal and bladder functions is essential for all PUV patients.


Introduction
Posterior urethral valve (PUV) is a congenital anomaly of the prostatic urethra in boys in the presence of a mucosal membrane causing urinary bladder outlet obstruction [1].PUV is the most common cause of urinary outlet obstruction leading to renal damage.Additionally, PUV is therapy problems) [5,9,10].One study reported 23 of 67 (34.8%)Iranian PUV boys developed ESRD at the ages of 1-15 years, with a mean renal survival rate of 7.8 years [11].

Objective
To determine the presentation, clinical course, therapy and outcomes of a cohort of Thai boys with PUV in a major tertiary care center, and to see if there were any reliable predictor variables of CKD development.

Patients and methods
We retrospectively reviewed the medical records of all boys diagnosed as PUV treated at the Pediatric Nephrology Clinic, Department of Pediatrics, Songklanagarind Hospital, Prince of Songkla University, Thailand during 1991-2020.

Statistical analysis
Descriptive results are presented as means and standard deviations or medians and interquartile ranges (IQR) for continuous variables as appropriate and frequencies and percentages for categorical variables.Fisher's exact test, rank-sum test or chi-square tests were performed to compare categorical factors between children with/ without CKD.Statistical significance was considered as a p-value < 0.05.R version 3.6.0was used for all analyses [20].

Results
A total of 82 medical records of boys diagnosed as PUV during the 30-year study period were reviewed, with 5 excluded for missing data.The 77 remaining boys were diagnosed at a median age of 4.8 months (IQR 0.8-28.7).The years of diagnosis, presentations, ages at last visit, UTI episodes, and outcomes at follow up including CKD development by age distributions are shown in Fig. 1; Table 1.

Surgical interventions
Of the 77 boys, 62 had surgical intervention, 48 valve ablation surgeries at a median age of 30.3 months (IQR 12.8-54.8)(17 without prior surgery, 29 following vesicostomy and 2 following both cystostomy and vesicostomy), 14 who had urinary bladder diversion, 11 vesicostomies, 2 cystostomies and 1 boy had a vesicostomy and later had a cystostomy.

Patient status
The median age at their last visit was 6.3 years (IQR 2.2-12.6);at that time there were 35 survivors, 5 deceased, and 37 lost to follow up for more than one year after their last visit.22 boys had had CKD (8 alive, 2 dead, 8 returned to their original hospital and 4 lost to follow up).Of the 8 surviving patients still under our care, 7 went on to ESRD, 2 were on CAPD, 3 on hemodialysis and 2 had had kidney transplantation.The causes of death of the 3 non-CKD patients who had died were pneumonia and severe infection, and one boy had also had multiple organ anomalies.
Table 2 compares the demographic data of the children with and without CKD, and the analysis found no significant variables which could reliably predict CKD.Table 3 compares the imaging results; hydronephrosis, hydroureter VUR and renal damage including age at valve ablation were not significantly different between the boys with/ without CKD.
During our follow up we found 19, 14, 11, 7 and 4 boys with failure to thrive, proteinuria, bladder dysfunction, hypertension and hematuria, respectively.Hypertension,

Discussion
From our 77 PUV boys, a plurality were diagnosed at 0-3 months of age and over half before 6 months.There were no prenatal diagnoses, and about 10% were diagnosed after 5 years.This age-of-diagnosis breakdown is similar to a study in 65 Thai boys from Bangkok in which the median age at diagnosis was 0.5 years (IQR 0.3-1.3)[21] while the median age at diagnosis in a study of 18 Korean boys was 22.0 months [4]; interestingly, in a study in 98 Iranian boys, 67% were diagnosed before one month of age and 20% were prenatally diagnosed [22].
The number of PUV boys was highest in the middle decade of our study, the 2000s, which is likely related to the fact that our institution was only established in 1982, and for the first decade we were just getting established in a low-resource developing country, but by the 2000s, the middle decade of the study, we were becoming well-established as the major referral center in southern Thailand and increasingly more cases were being referred to us, but then in the 2010s, the number of cases began to decrease as more specialists were working in the provincial and local hospitals in our region.Also in recent years, our hospital expansion has been limited by the number of beds, and only severe referral cases have been accepted (as indicated by the number of cases in our analysis which were returned to their original institution or lost to follow up due to missing medical data more than one year after the last visit).
The most common presentation of PUV is symptoms/ signs of urine retention (poor urine steam, dribbling) and related complications (UTI, AKI).In severe PUV, the patient may present with urine ascites, urinoma, palpable, firm urinary bladder, AKI, renal dysplasia, and/or CKD [6,9,21,23].UTI is the most common sign indicating congenital anomalies of the kidney and urinary tract (CAKUT), and earlier studies reported that around 30% of CAKUT patients had UTI as the first sign [24,25].In our study, UTI was the most common presentation, although the previously noted study in Bangkok boys reported that 81% of their patients presented with UTI [21].UTI is the most frequent morbidity in PUV, and in our study, three-fourths of the boys were complicated with UTI, and two-thirds had recurrence.
In our study, renal ultrasounds revealed a significant number of severe grades of hydronephrosis and/or bilateral hydronephrosis as well as VURs which indicated lower bladder obstruction, resulting in high pressure backing up through the ureter and renal pelvis which can cause renal damage.Severity of hydronephrosis, VUR and renal damage were not significantly different between the CKD and non-CKD boys at their last visits.
Urinary dribbling and poor urine stream are definitive symptoms of bladder obstruction, but were found in only 24% and 14% of our boys, respectively, while studies from Iran and Nigeria found poor urine stream in 43% [11] and 91% [23], respectively.Our low numbers could be explained by noting that urinary symptoms in infants may not be noticed by parents for two reasons, first, the infant is wearing a diaper, or second, was born with the symptoms and the parents, having seen only these voiding manifestations in the infant, think they are normal.Renal failure, the most serious complication of PUV, was found in 8 boys at the first visit, particularly in the 0-3 months group.In these 8 boys, renal function returned to normal in 6 boys after urinary drainage, while impaired renal function persisted in 2 boys.We did not find AKI in the older boys, as their initial PUV had been diagnosed and corrected at their first visit to their local hospitals, and they were only referred to us later for management of other PUV consequences following the AKI resolution.
Kidney function deterioration develops in utero and continues even after valve ablation since bladder dysfunction remains and causes pressure back to the kidney leading to various possible complications, including recurrent UTI.
Diagnosis at a younger age may result from a patient having severe symptoms of PUV and thus the parents seeking medical attention.At the end of our study, the median age of the boys was 6.3 years, and one-fourth of them had developed CKD.Caione et al. [10] followed 24 patients in Italy aged 18-34 years (mean 23) for 16-30 years (mean 19.5), of whom 13 (54.1%)and 5 (20.8%) had CKD and ESRD, respectively.Although the prevalence of CKD in PUV in our study was not comparable to the Caione study, due to different durations of follow up, the natural course of CKD is that the longer the follow up period, the higher the chance of CKD.Additionally, age at CKD diagnosis may have been delayed in some of our cases, since we are a referral center, and when some of the patients were brought to us for their first visit, the CKD was already advanced, and thus our data on the age of CKD diagnosis may have been incorrect, reflecting an older-than-actual age of CKD development, further resulting in a higher-than-normal probability of renal survival.
Usually, early diagnosis of PUV leads to early treatment and thus better results than in cases of delayed diagnosis.However, early diagnosis may also occur in cases with severe symptoms and/or complications leading to medical investigations, in which case the outcomes may be poor.If possible, intrauterine diagnosis and fetal intervention to decompress the urinary bladder are the best modalities to reduce further renal damage and allow normal lung development [24].In our study, the average age of the boys who had CKD at their last visit was significantly higher than the boys who did not have CKD (11.9 and 4.6 years, respectively), which reflects the fact that kidney function deteriorates over time, as further evidenced by the fact that the 10-year renal survival was 73.3%, also suggesting that the non-CKD boys were too young to have had CKD development.
Valve ablation is the definitive PUV correction, however, this procedure is usually delayed due to endoscopic size limitations, or a surgeon who can do the procedure is not available; urinary diversion should be done immediately after diagnosis, with initial tube insertion into the bladder for urinary drainage followed by vesicostomy or cystostomy [22].Our boys had valve ablation at the median age of 2.5 years, which is quite late compared to the report from Bangkok in which their boys had valve ablation at the median age of 0.75 years [21].
Although PUV is a correctable congenital anomaly, damage may occur before surgical correction.The earliest possible post-natal urinary drainage is desirable, but, unfortunately, in low-resource countries many prenatal modalities are not available, including neonatal cystoscopy.
In high-resource countries, modern advances in technology and equipment enable early diagnosis and treatment, leading to much better outcomes than in earlier times.But if a PUV causes renal damage in utero, the long-term outcomes remain unfavorable [7,24].After surgical correction, kidney and urinary bladder functions still need lifelong monitoring for delayed renal deterioration to maintain the patient's quality of life.
Bladder dysfunction often persists even after complete valve ablation [11].Surprisingly, one study found that bladder dysfunction was not a concern of a majority of parents, so there were few follow ups or urodynamic studies [25].This was also a limitation of our study, since during our follow up period, 11 boys developed bladder dysfunction, but this could be an underestimation since the diagnosis of this condition was usually based on a patient's history without urodynamic studies.
Failure to thrive, hypertension and proteinuria are the most common results of CKD, and in our study were found significantly more in the CKD group than in the group in which CKD had not yet developed.Failure to thrive is one of the most common consequences of CKD, however this may also be a consequence of chronic infection since PUV patients tend to have frequent recurrences of UTI.The prevalence of failure to thrive was also influenced by the duration of the follow up period.During the follow up period in our study, 25% of the boys showed signs of failure to thrive, compared to 15% of the Thai boys from the Bangkok study mentioned previously, even though the mean follow-up period of their study was 7.5 years and ours was 6.3 years.

Conclusion
77 PUV Thai boys over a 30-year period had an average 10-year renal survival of 73%.UTI was the most common presentation.Recurrent UTI was the most frequent consequence, followed by urinary bladder dysfunction.The PUV in our boys was also a severe CAKUT, a disease which develops initially in utero and has high morbidity and high mortality, and all of these patients were scheduled for lifelong follow up for renal and bladder functions.

Fig. 1
Fig. 1 Number of boys with posterior urethral valves in this study by year 99m AKI: acute kidney injury; CKD: chronic kidney disease; UTI: urinary tract infection failure to thrive, acute kidney injury and hematuria were significantly higher in the CDK boys.

Fig. 2
Fig. 2 Renal survival curve in 77 study posterior urethral valve boys

Table 1
Distribution of 77 study posterior urethral valve boys by age group and period of diagnosis, presentation, urinary tract infection, chronic kidney disease and last status

Table 2
Comparison of period of diagnosis, age of diagnosis and last visit, UTI episodes, treatment and outcomes in study posterior urethral valve boys with and without chronic kidney disease CKD: chronic kidney disease; IQR: interquartile range; SD: standard deviation; VUR: vesicoureteral reflux

Table 3
Comparison of imaging results and age of urethral valve ablation in study posterior urethral valve boys with and without chronic kidney disease CKD: chronic kidney disease; DMSA Scan: 99m Tc dimercaptosuccinic acid renal scan; VUR: vesicoureteral reflux