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  1. The co-existence of two genetically distinct metabolic disorders in the same patient has rarely been reported. Phenylketonuria (PKU) is an inborn error of the metabolism resulting from a phenylalanine hydroxyl...

    Authors: Daniela Concolino, Maria Rapsomaniki, Eliana Disabella, Simona Sestito, Maria G Pascale, Maria T Moricca, Giuseppe Bonapace, Elisea Arbustini and Pietro Strisciuglio

    Citation: BMC Pediatrics 2010 10:32

    Content type: Case report

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  2. Lactose intolerance is a common complication of diarrhoea in infants with malnutrition and a cause of treatment failure. A combination of nutritional injury and infectious insults in severe protein energy maln...

    Authors: Richard Nyeko, Israel Kalyesubula, Edison Mworozi and Hanifa Bachou

    Citation: BMC Pediatrics 2010 10:31

    Content type: Research article

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  3. Non-invasive ventilation (NIV) may be useful after extubation in children. Our objective was to determine postextubation NIV characteristics and to identify risk factors of postextubation NIV failure.

    Authors: Juan Mayordomo-Colunga, Alberto Medina, Corsino Rey, Andrés Concha, Sergio Menéndez, Marta Los Arcos and Irene García

    Citation: BMC Pediatrics 2010 10:29

    Content type: Research article

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  4. To determine the agents of poisoning and demographic distribution of children brought to Civil Hospital Karachi (CHK) with a history of accidental poison intake and to examine the factors associated with it.

    Authors: Nabeel Manzar, Syed Muhammad Ali Saad, Bushra Manzar and Syeda Shahzeen Fatima

    Citation: BMC Pediatrics 2010 10:28

    Content type: Research article

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  5. This randomized controlled trial aims to evaluate the effects of an early developmental intervention program on the development of young children in low- and low-middle-income countries who are at risk for neu...

    Authors: Jan L Wallander, Elizabeth McClure, Fred Biasini, Shivaprasad S Goudar, Omrana Pasha, Elwyn Chomba, Darlene Shearer, Linda Wright, Vanessa Thorsten, Hrishikesh Chakraborty, Sangappa M Dhaded, Niranjana S Mahantshetti, Roopa M Bellad, Zahid Abbasi and Waldemar Carlo

    Citation: BMC Pediatrics 2010 10:27

    Content type: Study protocol

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  6. The effects of intensive training for children with cerebral palsy (CP) remain uncertain. The aim of the study was to investigate the impact on motor function, quality of movements and everyday activities of t...

    Authors: Anne Brit Sorsdahl, Rolf Moe-Nilssen, Helga K Kaale, Jannike Rieber and Liv Inger Strand

    Citation: BMC Pediatrics 2010 10:26

    Content type: Research article

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  7. Cow's milk is the most common food allergen in infants and the diagnosis of cow's milk allergy is difficult, even with the use of several diagnostic tests. Therefore, elimination diets and challenge tests are ...

    Authors: Mário C Vieira, Mauro B Morais, José VN Spolidoro, Mauro S Toporovski, Ary L Cardoso, Gabriela TB Araujo, Victor Nudelman and Marcelo CM Fonseca

    Citation: BMC Pediatrics 2010 10:25

    Content type: Research article

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  8. Existing evidence indicates that once mature neonates with severe cardio-respiratory failure become eligible for Extra Corporeal Membrane Oxygenation (ECMO) their chances of intact survival are doubled if they...

    Authors: David J Field, Richard Firmin, Denis V Azzopardi, Frances Cowan, Edmund Juszczak and Peter Brocklehurst

    Citation: BMC Pediatrics 2010 10:24

    Content type: Study protocol

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  9. Raised intracranial pressure (ICP) is known to complicate both traumatic and non-traumatic encephalopathies. It impairs cerebral perfusion and may cause death due to global ischaemia and intracranial herniatio...

    Authors: Samson Gwer, Hellen Gatakaa, Leah Mwai, Richard Idro and Charles R Newton

    Citation: BMC Pediatrics 2010 10:23

    Content type: Research article

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  10. Diagnosis of neonatal infection is difficult, because of it's non-specific clinical presentation and the lack of reliable diagnostic tests. The purpose of this study was to examine the potential diagnostic val...

    Authors: J David M Edgar, Vanessa Gabriel, J Ruth Gallimore, Stanley A McMillan and Judith Grant

    Citation: BMC Pediatrics 2010 10:22

    Content type: Research article

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  11. Robust data on the prevalence of childhood disability and the circumstances and characteristics of disabled children is crucial to understanding the relationship between impairment and social disadvantage. It ...

    Authors: Clare M Blackburn, Nick J Spencer and Janet M Read

    Citation: BMC Pediatrics 2010 10:21

    Content type: Research article

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  12. Children at highest risk of developmental problems benefit from early identification and intervention. Investigating factors affecting child development at the time of transition to school may reveal opportuni...

    Authors: Suzanne C Tough, Jodi E Siever, Karen Benzies, Shirley Leew and David W Johnston

    Citation: BMC Pediatrics 2010 10:19

    Content type: Research article

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  13. Ethnic differences in the prevalence of asthma among children in the UK are under-researched. We aimed to determine the ethnic differences in the prevalence of asthma and atopic asthma in children from the mai...

    Authors: Melissa J Whitrow and Seeromanie Harding

    Citation: BMC Pediatrics 2010 10:18

    Content type: Research article

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  14. Muscle strength is important for young people with Down syndrome as they make the transition to adulthood, because their workplace activities typically emphasise physical rather than cognitive skills. Muscle s...

    Authors: Nora Shields, Nicholas F Taylor and Bo Fernhall

    Citation: BMC Pediatrics 2010 10:17

    Content type: Study protocol

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  15. Research indicates that in the United States, children experience healthier BMI and fitness levels during school vs. summer, but research is limited. The primary goal of this pilot study was to assess where ch...

    Authors: Alison Tovar, Keith Lividini, Christina D Economos, Sara Folta, Jeanne Goldberg and Aviva Must

    Citation: BMC Pediatrics 2010 10:16

    Content type: Research article

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  16. Preterm infants requiring assisted ventilation are at significant risk of both pulmonary and cerebral injury. Inhaled Nitric Oxide, an effective therapy for pulmonary hypertension and hypoxic respiratory failu...

    Authors: Lisa M Askie, Roberta A Ballard, Gary Cutter, Carlo Dani, Diana Elbourne, David Field, Jean-Michel Hascoet, Anna Maria Hibbs, John P Kinsella, Jean-Christophe Mercier, Wade Rich, Michael D Schreiber, Pimol Srisuparp, Nim V Subhedar, Krisa P Van Meurs, Merryn Voysey…

    Citation: BMC Pediatrics 2010 10:15

    Content type: Study protocol

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  17. Previous studies have reported postpartum depression to be associated with both positive and negative effects on early infant growth. This study examined the hypothesis that maternal postnatal depression may b...

    Authors: Veit Grote, Torstein Vik, Rüdiger von Kries, Veronica Luque, Jerzy Socha, Elvira Verduci, Clotilde Carlier and Berthold Koletzko

    Citation: BMC Pediatrics 2010 10:14

    Content type: Research article

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  18. Hypertension has been shown to start in early life and to track into adulthood. Detecting adolescents with hypertension and prehypertension will aid early intervention and reduce morbidity and mortality from t...

    Authors: Chukwunonso ECC Ejike, Chidiebere E Ugwu and Lawrence US Ezeanyika

    Citation: BMC Pediatrics 2010 10:13

    Content type: Research article

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  19. Various perinatal factors influencing neuromotor development are known from cross sectional studies. Factors influencing the age at which distinct abilities are acquired are uncertain. We hypothesized that the...

    Authors: Christian Denne, Sarah Maag, Nicole Heussen and Martin Häusler

    Citation: BMC Pediatrics 2010 10:12

    Content type: Research article

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  20. The prevalence of childhood obesity has increased dramatically in the last two decades and numerous efforts to understand, intervene on, and prevent this significant threat to children's health are underway fo...

    Authors: Carol Curtin, Sarah E Anderson, Aviva Must and Linda Bandini

    Citation: BMC Pediatrics 2010 10:11

    Content type: Research article

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  21. The strongest causal evidence that customary spanking increases antisocial behavior is based on prospective studies that control statistically for initial antisocial differences. None of those studies have inv...

    Authors: Robert E Larzelere, Ronald B Cox Jr and Gail L Smith

    Citation: BMC Pediatrics 2010 10:10

    Content type: Correspondence

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  22. Thyroid hormone treatment in children with congenital hypothyroidism can prevent intellectual disability. Guidelines recommend that children diagnosed with congenital hypothyroidism through newborn screening r...

    Authors: Alex R Kemper, Lijing Ouyang and Scott D Grosse

    Citation: BMC Pediatrics 2010 10:9

    Content type: Research article

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  23. Endothelial dysfunction is a complication of both obesity and obstructive sleep apnea syndrome (OSAS), the latter being highly prevalent among obese children. It is unknown whether obesity causes endothelial d...

    Authors: Rakesh Bhattacharjee, Wadha H Alotaibi, Leila Kheirandish-Gozal, Oscar Sans Capdevila and David Gozal

    Citation: BMC Pediatrics 2010 10:8

    Content type: Research article

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  24. There is very little evidence of the similarity of the mechanics of maternal and bottle feeding. We assessed the mechanics of sucking in exclusive breastfeeding, exclusive bottle feeding, and mixed feeding. Th...

    Authors: Angel Moral, Ignasi Bolibar, Gloria Seguranyes, Josep M Ustrell, Gloria Sebastiá, Cristina Martínez-Barba and Jose Ríos

    Citation: BMC Pediatrics 2010 10:6

    Content type: Research article

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  25. There is increasing evidence that tight blood glucose (BG) control improves outcomes in critically ill adults. Children show similar hyperglycaemic responses to surgery or critical illness. However it is not k...

    Authors: Duncan Macrae, John Pappachan, Richard Grieve, Roger Parslow, Simon Nadel, Margrid Schindler, Paul Baines, Peter-Marc Fortune, Zdenek Slavik, Allan Goldman, Ann Truesdale, Helen Betts, Elizabeth Allen, Claire Snowdon, Deborah Percy, Michael Broadhead…

    Citation: BMC Pediatrics 2010 10:5

    Content type: Study protocol

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  26. The UK has one of the lowest breastfeeding rates worldwide and in recent years the Government has made breastfeeding promotion one of its priorities. The UNICEF UK Baby Friendly Initiative is likely to increas...

    Authors: Gabriel Agboado, Elaine Michel, Elaine Jackson and Arpana Verma

    Citation: BMC Pediatrics 2010 10:3

    Content type: Research article

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  27. Central adiposity is related to chronic disease risk in adolescents. Racial differences in waist circumference have been identified using cross-sectional data from this age group. We tested for racial differen...

    Authors: David J Tybor, Alice H Lichtenstein, Gerard E Dallal, Stephen R Daniels and Aviva Must

    Citation: BMC Pediatrics 2010 10:2

    Content type: Research article

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  28. Infantile spasms represent a serious epileptic syndrome that occurs in the early infantile age. ACTH and Vigabatrin are actively investigated drugs in its treatment. This study describes the comparison of thei...

    Authors: Shahnaz Ibrahim, Shamshad Gulab, Sidra Ishaque and Taimur Saleem

    Citation: BMC Pediatrics 2010 10:1

    Content type: Research article

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  29. Weight loss of greater than 7% from birth weight indicates possible feeding problems. Inadequate oral intake causes weight loss and increases the bilirubin enterohepatic circulation. The objective of this stud...

    Authors: Ariel A Salas, Jorge Salazar, Claudia V Burgoa, Carlos A De-Villegas, Valeria Quevedo and Amed Soliz

    Citation: BMC Pediatrics 2009 9:82

    Content type: Research article

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  30. Parents are integral to the implementation of obesity prevention and management recommendations for children. Exploration of barriers to and facilitators of parental decisions to adopt obesity prevention recom...

    Authors: Kendrin R Sonneville, Nancy La Pelle, Elsie M Taveras, Matthew W Gillman and Lisa A Prosser

    Citation: BMC Pediatrics 2009 9:81

    Content type: Research article

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  31. The HIV prevalence in Malawi is 12% and Kamuzu Central Hospital (KCH), in the capital Lilongwe, is the main provider of adult and paediatric HIV services in the central region. The Lighthouse at KCH offers opt...

    Authors: Ralf Weigel, Portia Kamthunzi, Charles Mwansambo, Sam Phiri and Peter N Kazembe

    Citation: BMC Pediatrics 2009 9:80

    Content type: Research article

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  32. Decisions about interim analysis and early stopping of clinical trials, as based on recommendations of Data Monitoring Committees (DMCs), have far reaching consequences for the scientific validity and clinical...

    Authors: Ricardo M Fernandes, Johanna H van der Lee and Martin Offringa

    Citation: BMC Pediatrics 2009 9:77

    Content type: Research article

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  33. Co-bedding, a developmental care strategy, is the practice of caring for diaper clad twins in one incubator (versus separating and caring for each infant in separate incubators), thus creating the opportunity ...

    Authors: Marsha L Campbell-Yeo, C Celeste Johnston, KS Joseph, Nancy L Feeley, Christine T Chambers and Keith J Barrington

    Citation: BMC Pediatrics 2009 9:76

    Content type: Study protocol

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  34. Powdered infant formula (PIF) is not a sterile product, but this information appears to be poorly diffused among child caregivers. Parents and child care workers may behave in an unsafe manner when handling PIF.

    Authors: Giuseppe Calamusa, Rosalia Maria Valenti, Ivana Guida and Caterina Mammina

    Citation: BMC Pediatrics 2009 9:75

    Content type: Research article

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  35. Individuals grow and accumulate central patterns of body fat into the diseases they will suffer from as older adults. The need to elicit the development and tracking of central patterns of body fat from younge...

    Authors: Kotsedi D Monyeki, Han CG Kemper and Phuti J Makgae

    Citation: BMC Pediatrics 2009 9:74

    Content type: Research article

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  36. Early developmental interventions to prevent the high rate of neurodevelopmental problems in very preterm children, including cognitive, motor and behavioral impairments, are urgently needed. These interventio...

    Authors: Alicia J Spittle, Carmel Ferretti, Peter J Anderson, Jane Orton, Abbey Eeles, Lisa Bates, Roslyn N Boyd, Terrie E Inder and Lex W Doyle

    Citation: BMC Pediatrics 2009 9:73

    Content type: Study protocol

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  37. About 10-20% of neonates with suspected or proven early onset sepsis (EOS) fail on the empiric antibiotic regimen of ampicillin or penicillin and gentamicin. We aimed to identify clinical and laboratory marker...

    Authors: Tuuli Metsvaht, Heti Pisarev, Mari-Liis Ilmoja, Ülle Parm, Lea Maipuu, Mirjam Merila, Piia Müürsepp and Irja Lutsar

    Citation: BMC Pediatrics 2009 9:72

    Content type: Research article

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  38. Rates of preterm birth are increasing worldwide and this increase is mostly due to infants born between 34 and 36 weeks of gestational age, the so-called "late preterm" births. The aim of this study was to ass...

    Authors: Ina S Santos, Alicia Matijasevich, Marlos R Domingues, Aluísio JD Barros, Cesar G Victora and Fernando C Barros

    Citation: BMC Pediatrics 2009 9:71

    Content type: Research article

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  39. The gold standard to assess hyperbilirubinemia in neonates remains the serum bilirubin measurement. Unfortunately, this is invasive, painful, and costly. Bilimed®, a new transcutaneous bilirubinometer, suggests m...

    Authors: Tanja Karen, Hans Ulrich Bucher and Jean-Claude Fauchère

    Citation: BMC Pediatrics 2009 9:70

    Content type: Research article

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  40. To investigate determinants of antibiotic prescription in paediatric care, as a first step of a multilevel intervention to improve prescribing for common respiratory tract infections (RTIs) in a northern Itali...

    Authors: Maria Luisa Moro, Massimiliano Marchi, Carlo Gagliotti, Simona Di Mario and Davide Resi

    Citation: BMC Pediatrics 2009 9:69

    Content type: Research article

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  41. Knowledge about psychometric properties of the Pediatric Quality of Life Inventory (PedsQL) in the Netherlands is limited and Dutch reference data are lacking. Aim of the current study is to collect Dutch refe...

    Authors: Vivian Engelen, Marleen M Haentjens, Symone B Detmar, Hendrik M Koopman and Martha A Grootenhuis

    Citation: BMC Pediatrics 2009 9:68

    Content type: Research article

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  42. The World Health Organization recommends dry cord care for newborns but this recommendation may not be optimal in low resource settings where most births take place in an unclean environment and infections acc...

    Authors: Luke C Mullany, Shams El Arifeen, Peter J Winch, Rasheduzzaman Shah, Ishtiaq Mannan, Syed M Rahman, Mohammad R Rahman, Gary L Darmstadt, Saifuddin Ahmed, Mathuram Santosham, Robert E Black and Abdullah H Baqui

    Citation: BMC Pediatrics 2009 9:67

    Content type: Study protocol

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  43. Previous studies have shown that children's nonnutritive sucking habits may lead to delayed development of their oral anatomy and functioning. However, these findings were inconsistent. We investigated associa...

    Authors: Clarita Barbosa, Sandra Vasquez, Mary A Parada, Juan Carlos Velez Gonzalez, Chanaye Jackson, N David Yanez, Bizu Gelaye and Annette L Fitzpatrick

    Citation: BMC Pediatrics 2009 9:66

    Content type: Research article

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  44. Kawasaki Syndrome (KS) is an uncommon childhood disease with unknown etiology. It has been suggested that rotavirus infection may play a causative role in the development of KS.

    Authors: Adam MacNeil, Robert C Holman, Krista L Yorita, Claudia A Steiner, Umesh D Parashar and Ermias D Belay

    Citation: BMC Pediatrics 2009 9:65

    Content type: Research article

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