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  1. Despite new therapeutic approaches have improved the prognosis of newborns with retinopathy of prematurity (ROP), an unfavourable structural and functional outcome still remains high. There is high pressure to...

    Authors: Luca Filippi, Giacomo Cavallaro, Patrizio Fiorini, Marta Daniotti, Valentina Benedetti, Gloria Cristofori, Gabriella Araimo, Luca Ramenghi, Agostino La Torre, Pina Fortunato, Liliana Pollazzi, Giancarlo la Marca, Sabrina Malvagia, Paola Bagnoli, Chiara Ristori, Massimo Dal Monte…

    Citation: BMC Pediatrics 2010 10:83

    Content type: Study protocol

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  2. Medium chain acyl-CoA dehydrogenase deficiency (MCADD) is a disorder of mitochondrial fatty acid oxidation and is one of the most common inborn errors of metabolism. Identification of MCADD via newborn screeni...

    Authors: Shelley Kennedy, Beth K Potter, Kumanan Wilson, Lawrence Fisher, Michael Geraghty, Jennifer Milburn and Pranesh Chakraborty

    Citation: BMC Pediatrics 2010 10:82

    Content type: Research article

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  3. This systematic review aimed to evaluate the psychometric properties and clinical utility of all condition specific outcome measures used to assess quality of life (QOL) in school aged children with cerebral p...

    Authors: Stacey Carlon, Nora Shields, Katherine Yong, Rose Gilmore, Leanne Sakzewski and Roslyn Boyd

    Citation: BMC Pediatrics 2010 10:81

    Content type: Research article

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  4. Little is known about the efficacy and the working mechanisms of physical and occupational therapy interventions for children with cerebral palsy (CP). In recent years a shift from a child-focused intervention...

    Authors: Marjolijn Ketelaar, Anne JA Kruijsen, Olaf Verschuren, Marian J Jongmans, Jan Willem Gorter, Johannes Verheijden, Heleen A Reinders-Messelink and Eline Lindeman

    Citation: BMC Pediatrics 2010 10:80

    Content type: Study protocol

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  5. Persons with cerebral palsy (CP) are at risk for developing an inactive lifestyle and often have poor fitness levels, which may lead to secondary health complications and diminished participation and quality o...

    Authors: Jorrit Slaman, Marij E Roebroeck, Jetty van Meeteren, Wilma M van der Slot, Heleen A Reinders- Messelink, Eline Lindeman, Henk J Stam and Rita J van den Berg-Emons

    Citation: BMC Pediatrics 2010 10:79

    Content type: Study protocol

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  6. Children with poor motor ability have been found to engage less in physical activities than other children, and a lack of physical activity has been linked to problems such as obesity, lowered bone mineral den...

    Authors: Jan P Piek, Leon M Straker, Lynn Jensen, Alma Dender, Nicholas C Barrett, Sue McLaren, Clare Roberts, Carly Reid, Rosie Rooney, Tanya Packer, Greer Bradbury and Sharon Elsley

    Citation: BMC Pediatrics 2010 10:78

    Content type: Study protocol

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  7. Regular participation in physical activities is important for all children to stay fit and healthy. Children with cerebral palsy have reduced levels of physical activity, compared to typically developing child...

    Authors: Leontien Van Wely, Jules G Becher, Heleen A Reinders-Messelink, Eline Lindeman, Olaf Verschuren, Johannes Verheijden and Annet J Dallmeijer

    Citation: BMC Pediatrics 2010 10:77

    Content type: Study protocol

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  8. It is widely accepted that infants at risk for cerebral palsy need paediatric physiotherapy. However, there is little evidence for the efficacy of physiotherapeutic intervention. Recently, a new intervention p...

    Authors: Tjitske Hielkema, Elisa G Hamer, Heleen A Reinders-Messelink, Carel GB Maathuis, Arend F Bos, Tineke Dirks, Lily van Doormaal, Johannes Verheijden, Carla Vlaskamp, Eline Lindeman and Mijna Hadders-Algra

    Citation: BMC Pediatrics 2010 10:76

    Content type: Study protocol

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  9. Pregnancies induced by in vitro fertilisation (IVF) often result in twin gestations, which are associated with both maternal and perinatal complications. An effective way to reduce the number of IVF twin pregn...

    Authors: Mirjam MJ van Heesch, Gouke J Bonsel, John CM Dumoulin, Johannes LH Evers, Mark AHBM van der Hoeven, Johan L Severens, Ramon HM Dykgraaf, Fulco van der Veen, Nino Tonch, Willianne LDM Nelen, Piet van Zonneveld, Johannes B van Goudoever, Pieter Tamminga, Katerina Steiner, Corine Koopman-Esseboom, Catharina EM van Beijsterveldt…

    Citation: BMC Pediatrics 2010 10:75

    Content type: Study protocol

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  10. Important advances in the development and production of quality-certified pediatric antiretroviral (ARV) formulations have recently been made despite significant market disincentives for manufacturers. This pr...

    Authors: Brenda Waning, Ellen Diedrichsen, Elodie Jambert, Till Bärnighausen, Yun Li, Mieke Pouw and Suerie Moon

    Citation: BMC Pediatrics 2010 10:74

    Content type: Research article

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  11. Body Mass Index (BMI) is widely used to assess the impact of obesity on cardiometabolic risk in children but it does not always relate to central obesity and varies with growth and maturation. Waist-to-Height ...

    Authors: Jasmeet S Mokha, Sathanur R Srinivasan, Pronabesh DasMahapatra, Camilo Fernandez, Wei Chen, Jihua Xu and Gerald S Berenson

    Citation: BMC Pediatrics 2010 10:73

    Content type: Research article

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  12. In April 2009, a novel influenza A H1N1 (nH1N1) virus emerged and spread rapidly worldwide. News of the pandemic led to a heightened awareness of the consequences of influenza and generally resulted in enhance...

    Authors: Pranita D Tamma, Alison E Turnbull, Aaron M Milstone, Sara E Cosgrove, Alexandra Valsamakis, Alicia Budd and Trish M Perl

    Citation: BMC Pediatrics 2010 10:72

    Content type: Research article

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  13. Children with severe malnutrition who develop shock have a high mortality. Contrary to contemporaneous paediatric practice, current guidelines recommend use of low dose hypotonic fluid resuscitation (half-stre...

    Authors: Samuel O Akech, Japhet Karisa, Phellister Nakamya, Mwanamvua Boga and Kathryn Maitland

    Citation: BMC Pediatrics 2010 10:71

    Content type: Research article

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  14. There is a lack of high quality, child-centred and effective health information to support development of self-care practices and expertise in children with acute and long-term conditions. In type 1 diabetes, ...

    Authors: Jane P Noyes, Anne Williams, Davina Allen, Peter Brocklehurst, Cynthia Carter, John W Gregory, Carol Jackson, Mary Lewis, Lesley Lowes, Ian T Russell, Joanne Rycroft-Malone, Janice Sharp, Mark Samuels, Rhiannon Tudor Edwards and Rhiannon Whitaker

    Citation: BMC Pediatrics 2010 10:70

    Content type: Study protocol

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  15. Rotavirus remains the commonest cause of severe dehydrating diarrhea among children worldwide. Children in developing countries die more because of several factors including poorer access to hydration therapy ...

    Authors: Jane S Nakawesi, Eric Wobudeya, Grace Ndeezi, Edison A Mworozi and James K Tumwine

    Citation: BMC Pediatrics 2010 10:69

    Content type: Research article

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  16. Low concentrations of serum zinc have been reported in HIV infected adults and are associated with disease progression and an increased risk of death. Few studies have been conducted in HIV infected children i...

    Authors: Grace Ndeezi, James K Tumwine, Bjørn J Bolann, Christopher M Ndugwa and Thorkild Tylleskär

    Citation: BMC Pediatrics 2010 10:68

    Content type: Research article

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  17. Children with progressive metabolic, neurological, or chromosomal conditions and their families anticipate an unknown lifespan, endure unstable and often painful symptoms, and cope with erratic emotional and s...

    Authors: Harold Siden, Rose Steele, Rollin Brant, Susan Cadell, Betty Davies, Lynn Straatman, Kimberley Widger and Gail S Andrews

    Citation: BMC Pediatrics 2010 10:67

    Content type: Study protocol

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  18. Nosocomial Infections (NI) are a frequent and relevant problem. The purpose of this study was to determine the epidemiology of the three most common NI in a Pediatric Intensive Care Unit from a developing coun...

    Authors: María R Becerra, José A Tantaleán, Víctor J Suárez, Margarita C Alvarado, Jorge L Candela and Flor C Urcia

    Citation: BMC Pediatrics 2010 10:66

    Content type: Research article

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  19. This study aimed to profile levels of blood cells and serum cytokines during afebrile and febrile phases of periodic fever, aphthous stomatitis, pharyngitis and adenitis (PFAPA) syndrome to advance pathophysiolog...

    Authors: Kelly L Brown, Per Wekell, Veronica Osla, Martina Sundqvist, Karin Sävman, Anders Fasth, Anna Karlsson and Stefan Berg

    Citation: BMC Pediatrics 2010 10:65

    Content type: Research article

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  20. Stories may be an effective tool to communicate with and influence patients because of their ability to engage the reader. The objective of this paper is to describe the development of a story-based interventi...

    Authors: Lisa Hartling, Shannon Scott, Rena Pandya, David Johnson, Ted Bishop and Terry P Klassen

    Citation: BMC Pediatrics 2010 10:64

    Content type: Research article

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  21. Infant formulas are sophisticated milk-based feeds for infants which are used as a substitute for breast milk. Historically they are known to be contaminated by aluminium and in the past this has raised health...

    Authors: Shelle-Ann M Burrell and Christopher Exley

    Citation: BMC Pediatrics 2010 10:63

    Content type: Research article

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  22. Surveys in Vietnam have indicated that wasting and stunting have been prevalent among children, but the country is undergoing rapid socio-economic changes and little has been known about the relative situation...

    Authors: Arild Vaktskjold, Đoàn Văn Trí, Dương Trọng Phỉ and Torkjel Sandanger

    Citation: BMC Pediatrics 2010 10:62

    Content type: Research article

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  23. Earlier studies have shown an association between secondhand tobacco smoke and allergy development in children. Furthermore, there is an increased risk of developing an allergy if the parents have an allergy. ...

    Authors: Kristina Hansen, Elisabeth Mangrio, Martin Lindström and Maria Rosvall

    Citation: BMC Pediatrics 2010 10:61

    Content type: Research article

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  24. Menarcheal age is a sensitive indicator of environmental conditions during childhood. The aim of study is to determine the age at menarche and growth status in adolescents in a rural area of Tarka, Wannune, Ni...

    Authors: Daniel T Goon, Abel L Toriola, Jonathan Uever, Sarah Wuam and Olutoyin M Toriola

    Citation: BMC Pediatrics 2010 10:60

    Content type: Research article

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  25. One of the most serious, yet common co-morbidities of obesity is insulin resistance, which if untreated may progress to type 2 diabetes. This paper describes the insulin and glucose concentration distributions...

    Authors: Elizabeth Denney-Wilson, Christopher T Cowell, Anthony D Okely, Louise L Hardy, Robert Aitken and Timothy Dobbins

    Citation: BMC Pediatrics 2010 10:58

    Content type: Research article

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  26. Changing epidemiology and diagnostic difficulties of paediatric tuberculosis (TB) are being increasingly reported. Our aim was to describe clinico-epidemiological profile and diagnostic procedures used for pae...

    Authors: Chandrashekhar T Sreeramareddy, Narayan Ramakrishnareddy, Ravi K Shah, Ramkaji Baniya and Pradipta K Swain

    Citation: BMC Pediatrics 2010 10:57

    Content type: Research article

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  27. Scale up of paediatric antiretroviral therapy in resource limited settings continues despite limited access to routine laboratory monitoring. We documented the weight and height responses in HIV infected Ugand...

    Authors: Philippa M Musoke, Peter Mudiope, Linda N Barlow-Mosha, Patrick Ajuna, Danstan Bagenda, Michael M Mubiru, Thorkild Tylleskar and Mary G Fowler

    Citation: BMC Pediatrics 2010 10:56

    Content type: Research article

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  28. "Use it or lose it" is a well known saying which is applicable to boys with Duchenne Muscular Dystrophy (DMD). Besides the direct effects of the muscular dystrophy, the increasing effort to perform activities,...

    Authors: Merel Jansen, Imelda JM de Groot, Nens van Alfen and Alexander CH Geurts

    Citation: BMC Pediatrics 2010 10:55

    Content type: Study protocol

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  29. Since 2003 pediatric antiretroviral treatment (ART) programs have scaled-up in sub-Saharan Africa and should be evaluated to assess progress and identify areas for improvement. We evaluated secular trends in t...

    Authors: Catherine G Sutcliffe, Carolyn Bolton-Moore, Janneke H van Dijk, Matt Cotham, Bushimbwa Tambatamba and William J Moss

    Citation: BMC Pediatrics 2010 10:54

    Content type: Research article

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  30. Neonatal sepsis is difficult to diagnose and pathogens cannot be detected from blood cultures in many cases. Development of a rapid and accurate method for detecting pathogens is thus essential. The main purpo...

    Authors: Makoto Fujimori, Ken Hisata, Satoru Nagata, Nobuaki Matsunaga, Mitsutaka Komatsu, Hiromichi Shoji, Hiroaki Sato, Yuichiro Yamashiro, Takashi Asahara, Koji Nomoto and Toshiaki Shimizu

    Citation: BMC Pediatrics 2010 10:53

    Content type: Research article

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  31. Hyperglycemia in premature infants is associated with increased morbidity and mortality, but data on long-term outcome are limited. We investigated the effects of neonatal hyperglycemia (blood glucose ≥ 10 mmo...

    Authors: N Margreth van der Lugt, Vivianne EHJ Smits-Wintjens, Paul HT van Zwieten and Frans J Walther

    Citation: BMC Pediatrics 2010 10:52

    Content type: Research article

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  32. Many children with type 1 diabetes have poor glycaemic control. Since the Diabetes Control and Complications Trial (DCCT) showed that tighter control reduces complication rates, there has been more emphasis on...

    Authors: Katharine Barnard, Sian Thomas, Pamela Royle, Kathryn Noyes and Norman Waugh

    Citation: BMC Pediatrics 2010 10:50

    Content type: Research article

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  33. Some evidence suggests that obesity and behavior problems are related in children, but studies have been conflicting and have rarely included children under age 4. An association between behavior problems in e...

    Authors: Sarah E Anderson, Xin He, Sarah Schoppe-Sullivan and Aviva Must

    Citation: BMC Pediatrics 2010 10:49

    Content type: Research article

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  34. M. pneumoniae pneumonia (MP) has been reported in 10-40% of community-acquired pneumonia cases. We aimed to evaluate the difference of clinical features in children with MP, according to their age and chest radi...

    Authors: You-Sook Youn, Kyung-Yil Lee, Ja-Young Hwang, Jung-Woo Rhim, Jin-Han Kang, Joon-Sung Lee and Ji-Chang Kim

    Citation: BMC Pediatrics 2010 10:48

    Content type: Research article

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  35. We present a case of Xanthogranulomatous pyelonephritis (XGPN) in a male child with renal vein thrombus extending into the inferior vena cava. This is a rare presentation. XGPN is a rare type of renal infectio...

    Authors: Geetanjali Gupta, Reecha Singh, Dhananjay S Kotasthane, Vaishali D Kotasthane and Shailesh Kumar

    Citation: BMC Pediatrics 2010 10:47

    Content type: Case report

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  36. There are at least 51 adenovirus serotypes (AdV) known to cause human infections. The prevalence of the different human AdV (HAdV) serotypes varies among different regions. Presently, there are no reports of t...

    Authors: Juraina Abd-Jamil, Boon-Teong Teoh, Eddy H Hassan, Nuruliza Roslan and Sazaly AbuBakar

    Citation: BMC Pediatrics 2010 10:46

    Content type: Research article

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  37. Pediatric asthma is a serious public health problem in Chicago and has been designated a high priority concern by residents of Chicago's Humboldt Park, a diverse community area with a large number of Puerto Ri...

    Authors: Ruchi S Gupta, Juana Ballesteros, Elizabeth E Springston, Bridget Smith, Molly Martin, Eileen Wang and Maureen Damitz

    Citation: BMC Pediatrics 2010 10:45

    Content type: Research article

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  38. In Tanzania, less than a third of HIV infected children estimated to be in need of antiretroviral therapy (ART) are receiving it. In this setting where other infections and malnutrition mimic signs and symptom...

    Authors: Harriet Nuwagaba-Biribonwoha, Bazghina Werq-Semo, Aziz Abdallah, Amy Cunningham, John G Gamaliel, Sevestine Mtunga, Victoria Nankabirwa, Isaya Malisa, Luis F Gonzalez, Charles Massambu, Denis Nash, Jessica Justman and Elaine J Abrams

    Citation: BMC Pediatrics 2010 10:44

    Content type: Research article

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  39. Complementary feeding is currently recommended after six months of age, when the nutrients in breast milk alone are no longer adequate to support growth. Few studies have examined macro- and micro-nutrient int...

    Authors: James K Friel, Rhona M Hanning, Corinne A Isaak, Daniel Prowse and Angela C Miller

    Citation: BMC Pediatrics 2010 10:43

    Content type: Research article

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  40. The Rotavirus Efficacy and Safety Trial was a placebo-controlled Phase III study that evaluated the safety and efficacy of a three-dose pentavalent rotavirus vaccine (RV5) including its effect on healthcare ut...

    Authors: Robbin Itzler, Gary Koch, David O Matson, Leif Gothefors, Pierre Van Damme, Mark J DiNubile and Penny M Heaton

    Citation: BMC Pediatrics 2010 10:42

    Content type: Research article

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  41. Acid suppression with a proton pump inhibitor is standard treatment for gastroesophageal reflux disease and erosive esophagitis in adults and increasingly is becoming first-line therapy for children aged 1-17 ...

    Authors: Vasundhara Tolia, Nader N Youssef, Mark A Gilger, Barry Traxler and Marta Illueca

    Citation: BMC Pediatrics 2010 10:41

    Content type: Research article

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  42. Neonatal sepsis is a significant cause of morbidity and mortality in neonates. Appropriate clinical diagnosis and empirical treatment in a given setting is crucial as pathogens of bacterial sepsis and antibiot...

    Authors: Neema Kayange, Erasmus Kamugisha, Damas L Mwizamholya, Seni Jeremiah and Stephen E Mshana

    Citation: BMC Pediatrics 2010 10:39

    Content type: Research article

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  43. Respiratory syncytial virus (RSV) is an important pathogen causing annual epidemics of bronchiolitis and pneumonia among infants worldwide. High-risk infants currently receive RSV prophylaxis with palivizumab,...

    Authors: Pilar Fernández, Adrian Trenholme, Katia Abarca, M Pamela Griffin, Micki Hultquist, Brian Harris and Genevieve A Losonsky

    Citation: BMC Pediatrics 2010 10:38

    Content type: Research article

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  44. Bronchiolitis is the most common reason for admission of infants to hospital in developed countries. Fluid replacement therapy is required in about 30% of children admitted with bronchiolitis. There are curren...

    Authors: Ed Oakley, Franz E Babl, Jason Acworth, Meredith Borland, David Kreiser, Jocelyn Neutze, Theane Theophilos, Susan Donath, Mike South and Andrew Davidson

    Citation: BMC Pediatrics 2010 10:37

    Content type: Study protocol

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  45. Worldwide, insulin-dependent type 1 diabetes is one of the most frequently diagnosed long-term endocrine disorders found in children and the incidences of this diseased is still increasing. In Sweden the routi...

    Authors: Lisbeth Jönsson, Inger Hallström and Anita Lundqvist

    Citation: BMC Pediatrics 2010 10:36

    Content type: Research article

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  46. Over the past few years, great efforts have been made to screen duct-dependent congenital heart diseases in the newborn. Arterial pulse oximetry screening (foot and/or right hand) has been put forth as the mos...

    Authors: Christoph Rüegger, Hans Ulrich Bucher and Romaine Arlettaz Mieth

    Citation: BMC Pediatrics 2010 10:35

    Content type: Research article

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