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  1. Conotruncal heart defects (CTDs) are a subgroup of congenital heart defects that are considered to be the most common type of birth defect worldwide. Genetic disturbances in folate metabolism may increase the ...

    Authors: Xike Wang, Haitao Wei, Ying Tian, Yue Wu and Lei Luo
    Citation: BMC Pediatrics 2018 18:287
  2. Noonan syndrome (NS) is an autosomal dominant multisystem disorder caused by the dysregulation of several genes belonging to the RAS Mitogen Activated Protein Kinase (MAPK) signaling pathway. Incontinentia Pig...

    Authors: Nehla Ghedira, Arnaud Lagarde, Karim Ben Ameur, Sahar Elouej, Rania Sakka, Emna Kerkeni, Fatma-Zohra Chioukh, Sylviane Olschwang, Jean-Pierre Desvignes, Sonia Abdelhak, Valerie Delague, Nicolas Lévy, Kamel Monastiri and Annachiara De Sandre-Giovannoli
    Citation: BMC Pediatrics 2018 18:286
  3. A novel immunodeficiency, frequently accompanied by high serum-IgE, and caused by mutations in the PGM3 gene was described in 2014. To date there are no unique phenotype characteristics for PGM3 deficiency. PGM3 ...

    Authors: Karin E. Lundin, Qing Wang, Abdulrahman Hamasy, Per Marits, Mehmet Uzunel, Valtteri Wirta, Ann-Charlotte Wikström, Anders Fasth, Olov Ekwall and C.I. Edvard Smith
    Citation: BMC Pediatrics 2018 18:285
  4. The phenotypic and genetic heterogeneity of autism spectrum disorder (ASD) presents considerable challenges in understanding etiological pathways, selecting effective therapies, providing genetic counselling, ...

    Authors: Gail A. Alvares, Paul A. Dawson, Cheryl Dissanayake, Valsamma Eapen, Jacob Gratten, Rachel Grove, Anjali Henders, Helen Heussler, Lauren Lawson, Anne Masi, Emma Raymond, Felicity Rose, Leanne Wallace, Naomi R. Wray and Andrew J. O. Whitehouse
    Citation: BMC Pediatrics 2018 18:284
  5. The supply of breast milk to preterm infants tends to occur at a lower rate than that recorded among term infants. We aimed to investigate the facilitators of and barriers to breastfeeding during hospital stay...

    Authors: Maria Lorella Gianni, Elena Nicoletta Bezze, Patrizio Sannino, Michela Baro, Paola Roggero, Salvatore Muscolo, Laura Plevani and Fabio Mosca
    Citation: BMC Pediatrics 2018 18:283
  6. Noninvasive ventilation (NIV) is increasingly utilized in infants and young children, though associated with high failure rates due to agitation and poor compliance, mostly if patient-ventilator synchronizatio...

    Authors: M. Piastra, A. Pizza, S. Gaddi, E. Luca, O. Genovese, E. Picconi, D. De Luca and G. Conti
    Citation: BMC Pediatrics 2018 18:282
  7. Obese children and adolescents may vary with respect to their health profile, an observation that has been highlighted by the characterization of metabolically healthy obesity (MHO). The objectives of this stu...

    Authors: Lara Nasreddine, Hani Tamim, Aurelie Mailhac and Fadia S. AlBuhairan
    Citation: BMC Pediatrics 2018 18:281
  8. Survival of preterm neonates has steadily improved over the past five decades, due to changes in the neonatal intensive care. However, in Saudi Arabia, there are no written guidelines on the definition of the ...

    Authors: Mostafa A. Abolfotouh, Saif Al Saif, Waleed A. Altwaijri and Mohammed A. Al Rowaily
    Citation: BMC Pediatrics 2018 18:280
  9. Community Acquired Pneumonia (CAP) is the leading cause of childhood morbidity and mortality worldwide including India. Many of these deaths can be averted by creating awareness in community about early sympto...

    Authors: Shally Awasthi, Tuhina Verma, Monica Agarwal and Chandra Mani Pandey
    Citation: BMC Pediatrics 2018 18:279
  10. Variation in genes of the leptinergic-melanocortinergic system influence both body weight and height. Because short normal stature (SNS) is characterized by reduced body height, delayed maturation and leanness...

    Authors: Nikolas Herrfurth, Anna-Lena Volckmar, Triinu Peters, Gunnar Kleinau, Anne Müller, Cigdem Cetindag, Laura Schonnop, Manuel Föcker, Astrid Dempfle, Stefan A. Wudy, Struan F. A. Grant, Thomas Reinehr, Diana L. Cousminer, Johannes Hebebrand, Heike Biebermann and Anke Hinney
    Citation: BMC Pediatrics 2018 18:278
  11. Coxsackievirus A6 (CVA6) is one of the major agents to cause hand, foot and mouth disease (HFMD) outbreaks globally. The objective of this study is to investigate the epidemiologic and clinical manifestations ...

    Authors: Jie Li, Rong Zhu, Da Huo, Yiwei Du, Yuxiang Yan, Zhichao Liang, Yanxia Luo, Yang Yang, Lei Jia, Lijuan Chen, Quanyi Wang and Yan He
    Citation: BMC Pediatrics 2018 18:277
  12. Cerebral palsy (CP) is the most common cause of physical disability in childhood. A major challenge for delivering effective services for children with CP is the heterogeneity of the medical condition. Categor...

    Authors: Nihad A. Almasri, Maysoun Saleh, Sana Abu-Dahab, Somaya H. Malkawi and Eva Nordmark
    Citation: BMC Pediatrics 2018 18:276
  13. Following publication of the original article [1], the author requested for an acknowledgement to retrospectively be added to the ‘Acknowledgements’ section of the article [1].

    Authors: Annika Kruse, Christian Schranz, Markus Tilp and Martin Svehlik
    Citation: BMC Pediatrics 2018 18:273

    The original article was published in BMC Pediatrics 2018 18:156

  14. Care of children living with HIV comprises various issues, some considered challenging. One of the challenging areas is the serostatus disclosure to HIV-positive children. This study describes the current situ...

    Authors: Shinya Tsuzuki, Naoko Ishikawa, Hideki Miyamoto, Christopher Dube, Nangana Kayama, Janet Watala and Albert Mwango
    Citation: BMC Pediatrics 2018 18:272
  15. Sick newborns in neonatal units who are unable to breastfeed are fed expressed breast milk. In Sri Lanka, most mothers stay in hospital throughout baby’s stay to provide this milk freshly. In other countries m...

    Authors: Ranmali Rodrigo, Lisa H. Amir and Della A. Forster
    Citation: BMC Pediatrics 2018 18:271
  16. Necrotizing enterocolitis (NEC) is a leading cause of neonatal morbidity and mortality in premature infants. To date, no effective biomarkers exist to predict which premature infants will develop NEC, limiting...

    Authors: Terri Marin, Ravi M. Patel, John D. Roback, Sean R. Stowell, Ying Guo, Kirk Easley, Megan Warnock, Jane Skvarich and Cassandra D. Josephson
    Citation: BMC Pediatrics 2018 18:270
  17. Liver dysfunction is an independent risk factor for poor prognosis of patients with sepsis. The aim of this study is to evaluate the effects of continuous hemofiltration in patients with bacterial sepsis compl...

    Authors: Yun Cui, Xi Xiong, Fei Wang, Yuqian Ren, Chunxia Wang and Yucai Zhang
    Citation: BMC Pediatrics 2018 18:269
  18. Preterm infants are high risk for delayed neurodevelopment. The main goal is to develop a program of early intervention for very preterm infants that allows families to apply it continuously at home, and quant...

    Authors: Rita C. Silveira, Eliane Wagner Mendes, Rubia Nascimento Fuentefria, Nadia Cristina Valentini and Renato S. Procianoy
    Citation: BMC Pediatrics 2018 18:268
  19. The mortality rate due to severe sepsis is approximately 30–60%. Sepsis readily progresses to septic shock and multiple organ dysfunction, representing a significant problem in the pediatric intensive care uni...

    Authors: Hai peng Yan, Miao Li, Xiu lan Lu, Yi min Zhu, Wen-xian Ou-yang, Zheng hui Xiao, Jun Qiu and Shuang jie Li
    Citation: BMC Pediatrics 2018 18:267
  20. Trisomy 10 is very rarely diagnosed, especially in living persons. Most reports of trisomy 10 pertain to prenatal diagnosis of trisomy 10 in the fetus. In addition, trisomy 10 has been reported as part of part...

    Authors: Yang Gao, Yu-cong Ma, Yang-hua Ju and Ya-nan Li
    Citation: BMC Pediatrics 2018 18:266
  21. Ethiopia has made significant progress in reducing child mortality but newborn mortality has stagnated at around 29 deaths per 1000 births. The Maternal Health in Ethiopia Partnership (MaNHEP) was a 3.5-year i...

    Authors: Y. Amare, S. Paul and L. M. Sibley
    Citation: BMC Pediatrics 2018 18:265
  22. Seven years of age is a milestone for learning basic knowledge that is strongly related to attention abilities such as Alerting, Orienting, and Inhibition function, allowing for appropriate adaptation to prima...

    Authors: Hadrien Ceyte, Joëlle Rosenbaum, Isabelle Hamon, Maëlle Wirth, Sébastien Caudron and Jean-Michel Hascoët
    Citation: BMC Pediatrics 2018 18:264
  23. Neonatal hypothermia is a worldwide problem and an important contributing factor for Neonatal morbidity and mortality especially in developing countries. High prevalence of hypothermia has been reported from c...

    Authors: Birhanu Wondimeneh Demissie, Balcha Berhanu Abera, Tesfaye Yitna Chichiabellu and Feleke Hailemichael Astawesegn
    Citation: BMC Pediatrics 2018 18:263
  24. Much controversy exists about the optimal management of a patent ductus arteriosus (PDA) in preterm infants, especially in those born at a gestational age (GA) less than 28 weeks. No causal relationship has be...

    Authors: Tim Hundscheid, Wes Onland, Bart van Overmeire, Peter Dijk, Anton H. L. C. van Kaam, Koen P. Dijkman, Elisabeth M. W. Kooi, Eduardo Villamor, André A. Kroon, Remco Visser, Daniel C. Vijlbrief, Susanne M. de Tollenaer, Filip Cools, David van Laere, Anne-Britt Johansson, Catheline Hocq…
    Citation: BMC Pediatrics 2018 18:262

    The Update to this article has been published in Trials 2021 22:627

  25. Evidence suggests a strong association between nutrition during the first 1000 days (conception to 2 years of life) and cognitive development. Maternal docosahexaenoic acid (DHA) supplementation has been sugge...

    Authors: Shweta Khandelwal, M. K. Swamy, Kamal Patil, Dimple Kondal, Monica Chaudhry, Ruby Gupta, Gauri Divan, Mahesh Kamate, Lakshmy Ramakrishnan, Mrutyunjaya B. Bellad, Anita Gan, Bhalchandra S. Kodkany, Reynaldo Martorell, K. Srinath Reddy, Dorairaj Prabhakaran, Usha Ramakrishnan…
    Citation: BMC Pediatrics 2018 18:261
  26. The death of a child before or shortly after birth is frequently preceded by an end-of-life decision (ELD). Population-based studies of incidence and characteristics of ELDs in neonates and infants are rare, a...

    Authors: Laure Dombrecht, Kim Beernaert, Ellen Roets, Kenneth Chambaere, Filip Cools, Linde Goossens, Gunnar Naulaers, Luc De Catte, Joachim Cohen and Luc Deliens
    Citation: BMC Pediatrics 2018 18:260
  27. Universal HIV testing and treatment of infected children remain challenging in resource-limited settings (RLS), leading to undiagnosed children/adolescents and limited access to pediatric antiretroviral therap...

    Authors: Calixte Ida Penda, Carole Else Eboumbou Moukoko, Daniele Kedy Koum, Joseph Fokam, Cedric Anatole Zambo Meyong, Sandrine Talla and Paul Koki Ndombo
    Citation: BMC Pediatrics 2018 18:259
  28. Modified sport interventions run by physiotherapists have shown potential as cost-effective, engaging, and effective interventions to improve gross motor skills and support transition to real-world sports part...

    Authors: Georgina L. Clutterbuck, Megan L. Auld and Leanne M. Johnston
    Citation: BMC Pediatrics 2018 18:258
  29. Basic parenting research reveals that child mental health is associated with optimal parenting, which is composed of three key dimensions (structure, affiliation and autonomy support). The present study aims t...

    Authors: Mireille Joussemet, Geneviève A. Mageau, Marie-Pier Larose, Mélanie Briand and Frank Vitaro
    Citation: BMC Pediatrics 2018 18:257
  30. Twin-to-twin transfusion syndrome (TTTS) is a serious complication of 10–15% of twin or triplet pregnancies in which multiple fetuses share a single placenta. Communicating placental vessels allow one fetus (t...

    Authors: Christie Bolch, Michael Fahey, Dinah Reddihough, Katrina Williams, Susan Reid, Angela Guzys, Stephen Cole, Andrew Edwards, Alison Fung, Ryan Hodges, Ricardo Palma-Dias, Mark Teoh and Susan Walker
    Citation: BMC Pediatrics 2018 18:256
  31. Hypoxic-ischemic encephalopathy (HIE) is a rare neonatal condition affecting about 1‰ births. Despite a significant improvement in the management of this condition in the last ten years, HIE remains associated...

    Authors: Thierry Debillon, Nathalie Bednarek and Anne Ego
    Citation: BMC Pediatrics 2018 18:255
  32. Microphthalmia with linear skin defects (MLS) syndrome is a rare neurodevelopmental X-dominant disorder. It presents in females as it is normally lethal in males. Three causative genes for MLS syndrome (OMIM 3...

    Authors: Nina Prepeluh, Bojan Korpar, Andreja Zagorac, Boris Zagradišnik, Andreja Golub and Nadja Kokalj Vokač
    Citation: BMC Pediatrics 2018 18:254
  33. Sepsis is a leading cause of morbidity and mortality among newborns. C-reactive protein (CRP) and procalcitonin (PCT) have some limitations in the diagnosis of preterm neonatal sepsis. In this study, the cut-o...

    Authors: C. Aydemir, H. Aydemir, F. Kokturk, C. Kulah and A. G. Mungan
    Citation: BMC Pediatrics 2018 18:253
  34. Of children with hemiplegic cerebral palsy, 75% have impaired somatosensory function, which contributes to learned non-use of the affected upper limb. Currently, motor learning approaches are used to improve u...

    Authors: Belinda McLean, Misty Blakeman, Leeanne Carey, Roslyn Ward, Iona Novak, Jane Valentine, Eve Blair, Susan Taylor, Natasha Bear, Michael Bynevelt, Emma Basc, Stephen Rose, Lee Reid, Kerstin Pannek, Jennifer Angeli, Karen Harpster…
    Citation: BMC Pediatrics 2018 18:252
  35. Upper limb (UL) deficits in children with unilateral cerebral palsy (uCP) have traditionally been targeted with motor execution treatment models, such as modified Constraint-Induced Movement Therapy (mCIMT). H...

    Authors: Cristina Simon-Martinez, Lisa Mailleux, Els Ortibus, Anna Fehrenbach, Giuseppina Sgandurra, Giovanni Cioni, Kaat Desloovere, Nicole Wenderoth, Philippe Demaerel, Stefan Sunaert, Guy Molenaers, Hilde Feys and Katrijn Klingels
    Citation: BMC Pediatrics 2018 18:250
  36. Our aim was to design a study to evaluate the effectiveness and cost-effectiveness of adding physiotherapy to conventional treatment for children with functional constipation in primary care. Physiotherapy is ...

    Authors: Jojanneke J. G. T. van Summeren, Gea A. Holtman, Yvonne Lisman- van Leeuwen, Lisa E. A. M. Louer, Alice H. C. van Ulsen-Rust, Karin M. Vermeulen, Boudewijn J. Kollen, Janny H. Dekker and Marjolein Y. Berger
    Citation: BMC Pediatrics 2018 18:249
  37. Functional hand splinting is a common therapeutic intervention for children with neurological conditions. The aim of this study was to investigate the effectiveness of the Cognitive Orientation to daily Occupa...

    Authors: Michelle Jackman, Iona Novak, Natasha Lannin, Elspeth Froude, Laura Miller and Claire Galea
    Citation: BMC Pediatrics 2018 18:248
  38. Acetaminophen is a common cause of acute liver failure in pediatrics. Cerebral edema is a significant complication of acute hepatic failure and is associated with increased mortality.

    Authors: Emily B. Austin, Hailey Hobbs, Brian A. Crouse and Anna-Theresa Lobos
    Citation: BMC Pediatrics 2018 18:247
  39. Children commonly present to Emergency Departments (ED) with a non-blanching rash in the context of a feverish illness. While most have a self-limiting viral illness, this combination of features potentially r...

    Authors: Thomas Waterfield, Mark D. Lyttle, Derek Fairley, James Mckenna, Kerry Woolfall, Fiona Lynn, Julie-Ann Maney, Damian Roland, Aoife Weir and Michael D. Shields
    Citation: BMC Pediatrics 2018 18:246
  40. Childhood obesity is one of the most challenging public health issues of twenty-first century. While we know that there is an increase in prevalence of childhood and adolescence obesity, incidence studies must...

    Authors: Maryam Barzin, Shayan Aryannezhad, Sara Serahati, Akram Beikyazdi, Fereidoun Azizi, Majid Valizadeh, Maryam Ziadlou and Farhad Hosseinpanah
    Citation: BMC Pediatrics 2018 18:245
  41. In hospital, staff need to routinely monitor patients to identify those who are seriously ill, so that they receive timely treatment to improve their condition. A Paediatric Early Warning System is a multi-fac...

    Authors: Emma Thomas-Jones, Amy Lloyd, Damian Roland, Gerri Sefton, Lyvonne Tume, Kerry Hood, Chao Huang, Dawn Edwards, Alison Oliver, Richard Skone, David Lacy, Ian Sinha, Jenny Preston, Brendan Mason, Nina Jacob, Robert Trubey…
    Citation: BMC Pediatrics 2018 18:244
  42. Pediatric non-adherence to antiretroviral therapy (ART), loss to follow-up, and HIV drug resistance (HIVDR) are challenges to achieving UNAIDS’ targets of 90% of those diagnosed HIV-positive receiving treatmen...

    Authors: Nanlesta A. Pilgrim, Jerry Okal, James Matheka, Irene Mukui and Samuel Kalibala
    Citation: BMC Pediatrics 2018 18:243
  43. Unlicensed and off label drug use is an issue recognized worldwide in pediatric pharmacotherapy. The study was designed to assess the prevalence and predictors of unlicensed and off label drug use in neonatal ...

    Authors: Muhammad Aamir, Jamshaid Ali Khan, Faisal Shakeel, Rabeea Shareef and Nazia Shah
    Citation: BMC Pediatrics 2018 18:242
  44. Diarrhoeal disease is the second leading cause of death among children aged below 5 years. Even though, both preventable and treatable diseases, globally there are nearly 1.7 billion cases of childhood diarrho...

    Authors: Wondwossen Abebe, Alemu Earsido, Solomon Taye, Mesfin Assefa, Adane Eyasu and Girma Godebo
    Citation: BMC Pediatrics 2018 18:241
  45. Acute respiratory tract infections contribute significantly to morbidity and mortality among young children in resource-poor countries. However, studies on the viral aetiology of acute respiratory infections, ...

    Authors: Temitayo Famoroti, Wilbert Sibanda and Thumbi Ndung’u
    Citation: BMC Pediatrics 2018 18:240
  46. Early discharge of very low birth weight infant (VLBW) in low resource settings is inevitable but to minimize mortality of these infants after discharge we need to identify the death attributes.

    Authors: Yaser Abdallah, Flavia Namiiro, Jolly Nankunda, Jamiru Mugalu and Yvonne Vaucher
    Citation: BMC Pediatrics 2018 18:239
  47. Children initially hospitalized with severe anaemia in Africa are at high risk of readmission or death within 6 months after discharge. No intervention strategy specifically protects children during the post-d...

    Authors: Thandile Gondwe, Bjarne Robberstad, Mavuto Mukaka, Siri Lange, Bjørn Blomberg and Kamija Phiri
    Citation: BMC Pediatrics 2018 18:238

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