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  1. Goiter is a common presenting sign of various thyroid diseases in children. Thyroid nodules are clinically and/or radiologically significant findings due to their high malignancy rate. The ultrasound (US) char...

    Authors: Fahad Al Juraibah, Khalid Al Noaim, Abdulaziz AlDbas, Ahmed AlMuallimi, Omar AlOtaibi, Mozon AlShareef, Alanoud AlSuhibani, Ahmed AlZaharani, Mohammed AlDubayee and Amir Babiker
    Citation: BMC Pediatrics 2022 22:642
  2. Primary intussusception in children is a common acute abdominal disease. The cause of this disease is still not fully understood. Many articles have reported that children with intussusception are often accomp...

    Authors: Qingtao Yan, Liandi Xu, Jun Chao, Zemin Zhang and Hui Wang
    Citation: BMC Pediatrics 2022 22:641
  3. COPA syndrome is a rare hereditary inflammatory disease caused by mutations in the gene encoding the coatomer protein subunit alpha, causing excessive production of type I interferon.

    Authors: Pietro Basile, Giulia Gortani, Andrea Taddio, Serena Pastore, Federica Corona, Alessandra Tesser, Egidio Barbi and Alberto Tommasini
    Citation: BMC Pediatrics 2022 22:639
  4. Although most cases of childhood cancer are unlikely to be prevented, by today’s standards, most children with cancer can now be cured. However, disparities about survival exist among countries; in Mexico, the...

    Authors: Leslie V. Uribe-Ortiz, Bárbara M. Garza-Ornelas, Ana C. Vázquez-Fernández, Fabiola Castorena-Torres and Julieta Rodríguez-De-Ita
    Citation: BMC Pediatrics 2022 22:638
  5. In respiratory distress syndrome, many neonatology centers worldwide perform minimal invasive surfactant application in premature infants, using small-diameter catheters for endotracheal intubation and surfact...

    Authors: Lorenz Auer-Hackenberg, Johannes Brandner, Edda Hofstätter, Patricia Stroicz, Tobias Hager, Anna Eichhorn, Sebastian Schütz, Raphael Feldner and Martin Wald
    Citation: BMC Pediatrics 2022 22:637
  6. This case–control study aimed to compare lead (Pb), cadmium (Cd), and arsenic (As) levels in neonates with respiratory distress syndrome (NRDS) with those levels in normal neonates and tested their association...

    Authors: Khalid M. Mohany, Osama Mahmoud El-Asheer, Yaser F. Abdel Raheem, Ahmed Abd-Elrasoul sayed and Mona Abd El-Hamid Hassan El-Baz
    Citation: BMC Pediatrics 2022 22:635
  7. In recent years, obesity and vitamin D deficiency are more prevalent among adolescents. Improving our knowledge of the link between vitamin D and visceral adipose tissue (VAT) is essential for the health of ad...

    Authors: Yan-feng Li, Xiao Zheng, Wen-lan Gao, Feng Tao and Yi Chen
    Citation: BMC Pediatrics 2022 22:634
  8. Acute infections are a common reason for children to consult primary care. Serious infections are rare but differentiating them from self-limiting illnesses remains challenging. This can lead to inappropriate ...

    Authors: Liselore De Rop, Tine De Burghgraeve, An De Sutter, Frank Buntinx and Jan Y Verbakel
    Citation: BMC Pediatrics 2022 22:633
  9. Spinal muscular atrophy (5q-SMA; SMA), a genetic neuromuscular condition affecting spinal motor neurons, is caused by defects in both copies of the SMN1 gene that produces survival motor neuron (SMN) protein. The...

    Authors: John W. Day, Kelly Howell, Amy Place, Kimberly Long, Jose Rossello, Nathalie Kertesz and George Nomikos
    Citation: BMC Pediatrics 2022 22:632
  10. Neonatal lupus erythematosus is a rare multisystem autoimmune disorder that predominantly involves the heart with congenital heart block but can involve other organs including the liver. The disease results fr...

    Authors: Ammar Abdulaziz Khayat and Amani Jaboor Alkhaldi
    Citation: BMC Pediatrics 2022 22:630
  11. As sequencing technology has advanced in recent years, a series of synapse-related gene variants have been reported to be associated with autism spectrum disorders (ASDs). The α-amino-3-hydroxy-5-methyl-4-isox...

    Authors: Qianyun Cai, Zhongjie Zhou, Rong Luo, Tao Yu, Dengfeng Li, Fan Yang and Zuozhen Yang
    Citation: BMC Pediatrics 2022 22:629
  12. Very low birth weight (VLBW: ≤1500 g) is associated with multiple short and long-term complications. This study aimed to examine outcomes and predictors of functioning, mental health, and health-related qualit...

    Authors: Arnt Erik Karlsen Wollum, Elias Kjølseth Berdal, Johanne Marie Iversen, Marit S. Indredavik and Kari Anne I. Evensen
    Citation: BMC Pediatrics 2022 22:628
  13. Deficiencies in oral motor function and feeding skills are common in children with cerebral palsy (CP). Oral motor therapy is a useful method to improve oral motor function and feeding skills. Oral motor facil...

    Authors: Kyoung-chul Min, Sang-min Seo and Hee-soon Woo
    Citation: BMC Pediatrics 2022 22:626
  14. We previously reported that 1-year-old infants born to mothers who regularly consumed fermented food during pregnancy had a lower risk of sleep deprivation. However, it is not known if these positive effects a...

    Authors: Mariko Inoue, Kenta Matsumura, Narumi Sugimori, Kei Hamazaki, Akiko Tsuchida and Hidekuni Inadera
    Citation: BMC Pediatrics 2022 22:624
  15. Very preterm infants often require mechanical ventilation. However, objective criteria to predict the outcomes of extubation in very premature neonates remain lacking. The aim of this study was to investigate ...

    Authors: Zhe Li, Jiang Xue, Xin-Yuan Guo, Fang Wang, Xue Zhang, Qi Li, Jing-Liang Tang, Juan Ji and Guang-Jun Du
    Citation: BMC Pediatrics 2022 22:627
  16. Idiopathic connective tissue disease juvenile dermatomyositis (JDM) is characterised by inflammatory myositis and distinctive skin abnormalities. Only a few cases of Dermatomyositis (DM) owing to chemotherapy ...

    Authors: Keta Vagha, Chitturi Venkata Sai Akhil, Spandana Madirala, Ashish Varma, Mahaveer Lakra and Jayant Vagha
    Citation: BMC Pediatrics 2022 22:623
  17. Neonatal hemochromatosis causes acute liver failure during the neonatal period, mostly due to gestational alloimmune liver disease (GALD). Thalassemia causes hemolytic anemia and ineffective erythropoiesis due...

    Authors: Mitsuru Tsuge, Aya Kodera, Hiromi Sumitomo, Tooru Araki, Ryuichi Yoshida, Kazuya Yasui, Hiroki Sato, Yosuke Washio, Kana Washio, Kenji Shigehara, Masato Yashiro, Takahito Yagi and Hirokazu Tsukahara
    Citation: BMC Pediatrics 2022 22:622
  18. Childhood vaccination rates in Armenia are high. However, anecdotal evidence suggests that some health workers may advise against vaccination. The extent and reasons behind this are unknown. This study used th...

    Authors: Cath Jackson, Siff Malue Nielsen, Brigida Simonyan, Marine Kirakosyan, Marine Hovhannisyan, Gayane Sahakyan and Katrine Bach Habersaat
    Citation: BMC Pediatrics 2022 22:620
  19. Electroencephalogram and neuroimaging in pediatric patients with new-onset afebrile seizures are performed to detect any underlying pathological severe condition that may require emergent neuro-intervention an...

    Authors: Noman Ali, Sohaib Haider, Syed Mustahsan, Murk Shaikh, Ahmed Raheem, Salman Muhammad Soomar and Shahan Waheed
    Citation: BMC Pediatrics 2022 22:619
  20. Multiple ear infections is causing hearing impairment among children all over the world and the health and social consequences track into early adolescence and later in life, if not treated. The monitoring of ...

    Authors: Christina Schnohr, Jakob Schmidt Jensen, Cecilie Friis Skovsen, Preben Homøe, Birgit Niclasen and Ramon Gordon Jensen
    Citation: BMC Pediatrics 2022 22:618
  21. Necrotizing enterocolitis (NEC) is a disastrous gastrointestinal disease of newborns, and the mortality rate of infants with NEC is approximately 20%-30%. The exploration of pathogenic targets of NEC will be c...

    Authors: Yujie Han, Xianghong Liu, Lili Kang, Dong Chen, Yongqing Li, Huiping Zhang, Mingying Sun, Hui Gao, Zhongtao Gai and Xiaoying Li
    Citation: BMC Pediatrics 2022 22:617
  22. Supplementary treatment options after pediatric severe traumatic brain injury (TBI) are needed to improve neurodevelopmental outcome. Evidence suggests enhancement of brain delta waves via auditory phase-targe...

    Authors: Joëlle Ninon Albrecht, Valeria Jaramillo, Reto Huber, Walter Karlen, Christian Rainer Baumann and Barbara Brotschi
    Citation: BMC Pediatrics 2022 22:616
  23. Childhood asthma has substantial effects on children's health. It is important to identify factors in early life that influence childhood asthma. Accumulating evidence indicates that Helicobacter pylori may pr...

    Authors: Donghai Wang, Yuxia Chen, Yuan Ding and Jinwei Tu
    Citation: BMC Pediatrics 2022 22:615
  24. Severe infant eczema on the face should be treated early because it may lead to allergic diseases in the future. However, caregivers find it difficult to assess. A visual tool for caregivers is needed to easil...

    Authors: Manami Matsubara, Megumi Haruna, Kaori Yonezawa, Moeri Yokoyama, Emi Tahara-Sasagawa, Naoko Hikita, Yoshie Nakamura, Yoko Mizuno, Hiromi Sanada, Nao Tamai, Masatoshi Abe and Kosuke Kashiwabara
    Citation: BMC Pediatrics 2022 22:614
  25. Several individual studies from specific countries have reported rising numbers of pediatric COVID-19 cases with inconsistent reports on the clinical symptoms including respiratory and gastrointestinal symptom...

    Authors: Fardis Vosoughi, Rangarirai Makuku, Marcarious M. Tantuoyir, Farbod Yousefi, Parnian Shobeiri, Amirali Karimi, Sanam Alilou, Ronald LaPorte, Curtis Tilves, Mohammad Hossein Nabian and Mir Saeed Yekaninejad
    Citation: BMC Pediatrics 2022 22:613
  26. Infantile hypotonia with psychomotor retardation and characteristic facies type 3(IHPRF3) (OMIM #616,900) is an autosomal recessive disorder caused by biallelic pathogenic variants of the TBCK gene, and to date, ...

    Authors: Hao-Yi Tan, Bin Wang and Yuan-Zong Song
    Citation: BMC Pediatrics 2022 22:612
  27. Care practices for very preterm infants and the mortality and morbidity of the infants vary widely among countries and regions with different levels of economic development, including the different areas in Ch...

    Authors: Haibo Peng, Yanling Shi, Fei Wang, Zhenchao Jin, Cungui Li, Jing Kang, Guofei Zhang, Lian Zhang, Yanli Yao and Zhangbin Yu
    Citation: BMC Pediatrics 2022 22:611
  28. Childhood immunization has been globally recognized as the single most effective strategy in preventing childhood diseases and mortality. The perceptions of healthcare workers are important as their behavior a...

    Authors: Preeti Balgovind and Masoud Mohammadnezhad
    Citation: BMC Pediatrics 2022 22:610
  29. Congenital heart diseases (CHD) are the commonest congenital anomalies with increased risk in children born from families with affected members. However, various recurrence patterns of CHDs have been reported ...

    Authors: Shaimaa Rakha, Rehab Mohy-Eldeen, Mohammad Al-Haggar and Mohammed Attia El-Bayoumi
    Citation: BMC Pediatrics 2022 22:607
  30. Globally more than 650,000 newborns died on their first day of life from birth asphyxia. The outcome of an asphyxiated newborn depends on the quality of care they received at birth. However, the quality of car...

    Authors: Nuredin Mohammed Guta
    Citation: BMC Pediatrics 2022 22:605
  31. Childhood obesity is potentially affected by breastfeeding, parents’ body mass index and birth weight. Thus, this study aimed to verify the association between breastfeeding, parents’ body mass index and birth...

    Authors: Maurício dos Santos, Gerson Ferrari, Clemens Drenowatz, José Matheus Estivaleti, Eduardo Rossato de Victo, Luis Carlos de Oliveira and Victor Matsudo
    Citation: BMC Pediatrics 2022 22:604
  32. Renal–hepatic–pancreatic dysplasia type 1 (RHPD1) is a rare sporadic and autosomal recessive disorder with unknown incidence. RHPD1 is caused by biallelic pathogenic variants in NPHP3, which encode nephrocystin, ...

    Authors: Hui Zhu, Zhi-hui Zhao, Shu-yao Zhu, Fu Xiong, Li-hong He, Yong Zhang and Jin Wang
    Citation: BMC Pediatrics 2022 22:603
  33. Early Infant Diagnosis was launched in India in 2010 and its effect on the diagnosis of HIV-exposed infants needs to be assessed. The present study was done to find out the median age at DBS sample collection ...

    Authors: Nilesh Gawde, Suchit Kamble, Noopur Goel, Kalyani Nikhare, Shilpa Bembalkar, Mohan Thorwat, Dhanashree Jagtap, Swarali Kurle, Neeru Yadav, Vinita Verma, Neha Kapoor and Chinmoyee Das
    Citation: BMC Pediatrics 2022 22:602
  34. Emery-Dreifuss Muscular Dystrophy (EDMD) is an uncommon genetic disease among the group of muscular dystrophies. EDMD is clinically heterogeneous and resembles other muscular dystrophies. Mutation of the lamin...

    Authors: Kristy Iskandar, Sunartini, Farida Niken Astari, Rizki Amalia Gumilang, Nissya Ilma, Ni Putu Shartyanie, Guritno Adistyawan, Grace Tan, Gunadi and Poh San Lai
    Citation: BMC Pediatrics 2022 22:601
  35. In-home unintentional injuries (IUIs) seriously threatened children’s safety. Three factors, including risky behaviors, parental supervision, and home environmental risks, have been identified as major causes ...

    Authors: Yihan Ma, Juan Song, Ming Hu, Rusi Yang and Panzi Yang
    Citation: BMC Pediatrics 2022 22:598
  36. End-of-life decisions with potential life-shortening effect in neonates and infants are common. We aimed to evaluate how often and in what manner neonatologists consult with parents and other healthcare provid...

    Authors: Laure Dombrecht, Filip Cools, Joachim Cohen, Luc Deliens, Linde Goossens, Gunnar Naulaers, Kim Beernaert and Kenneth Chambaere
    Citation: BMC Pediatrics 2022 22:597
  37. Advances in genetic and pharmaceutical technology and pediatric care have enabled treatment options for an increasing number of rare diseases in affected children. However, as current treatment options are pri...

    Authors: Silke Wiegand-Grefe, Anna Liedtke, Lydia Morgenstern, Antonia Hoff, Anikó Csengoe-Norris, Jessika Johannsen, Jonas Denecke, Claus Barkmann, Benjamin Grolle, Anne Daubmann, Karl Wegscheider and Johannes Boettcher
    Citation: BMC Pediatrics 2022 22:596
  38. Parents of children who are diagnosed with a poor-prognosis cancer want to be involved in making treatment-related decisions for their child. They often make repeated decisions depending on their child’s respo...

    Authors: Helen Pearson H, Gemma Bryan, Catherine Kayum, Faith Gibson and Anne-Sophie Darlington
    Citation: BMC Pediatrics 2022 22:595
  39. To discuss the clinical and prognostic indicators of pediatric malignant rhabdoid tumor of the kidney (MRTK), and to increase the understanding of the occurrence and development of MRTK.

    Authors: Chenghao Zhanghuang, Zhaoxia Zhang, Li Zeng, Bing Yan, Haoyu Tang, Jinkui Wang, Xing Liu, Guanghui Wei and Dawei He
    Citation: BMC Pediatrics 2022 22:591

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