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Neonatology

Section edited by Elizabeth Asztalos

This section considers studies regarding all aspects of neonatal health, disease, care, and outcomes.

Page 8 of 10

  1. Preterm infants are at risk for neurodevelopmental disorders, including motor, cognitive or behavioural problems, which may potentially be modified by early intervention. The EU CareToy Project Consortium (

    Authors: Giuseppina Sgandurra, Laura Bartalena, Giovanni Cioni, Gorm Greisen, Anna Herskind, Emanuela Inguaggiato, Jakob Lorentzen, Jens Bo Nielsen and Elisa Sicola

    Citation: BMC Pediatrics 2014 14:268

    Content type: Study protocol

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  2. Neonatal septicaemia diagnosis based on clinical features alone is non-specific leading to the initiation of unnecessary antibiotic treatment posing a danger of increased antibiotic resistance. In the present ...

    Authors: Flora Chacha, Mariam M Mirambo, Martha F Mushi, Neema Kayange, Antke Zuechner, Benson R Kidenya and Stephen E Mshana

    Citation: BMC Pediatrics 2014 14:248

    Content type: Research article

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  3. Pre-term infants who develop bronchopulmonary dysplasia (BPD) are at risk of postnatal growth failure. It has been reported that energy expenditure is higher in infants with BPD than in those without BPD. The ...

    Authors: Maria Lorella Giannì, Paola Roggero, Maria Rosa Colnaghi, Pasqua Piemontese, Orsola Amato, Anna Orsi, Laura Morlacchi and Fabio Mosca

    Citation: BMC Pediatrics 2014 14:235

    Content type: Research article

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  4. Each year an estimated 10 million newborns require assistance to initiate breathing, and about 900 000 die due to intrapartum-related complications. Further research is required in several areas concerning neo...

    Authors: Caroline Lindbäck, Ashish KC, Johan Wrammert, Ravi Vitrakoti, Uwe Ewald and Mats Målqvist

    Citation: BMC Pediatrics 2014 14:233

    Content type: Research article

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  5. The admission of a very premature infant to the neonatal intensive care unit (NICU) is often a difficult time for parents. This paper explores parents’ views and experiences of the care for their very prematur...

    Authors: Gillian Russell, Alexandra Sawyer, Heike Rabe, Jane Abbott, Gillian Gyte, Lelia Duley and Susan Ayers

    Citation: BMC Pediatrics 2014 14:230

    Content type: Research article

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  6. Hypoxic-ischemic injury is thought to play a significant role in necrotizing enterocolitis (NEC). Nitric Oxide (NO) is the principal inhibitory neurotransmitter in the gut and is involved in regulation of muco...

    Authors: Kevin Mitchell, Alexander Lyttle, Harish Amin, Huma Shaireen, Helen Lee Robertson and Abhay K Lodha

    Citation: BMC Pediatrics 2014 14:226

    Content type: Research article

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  7. Bacterial meningitis is more common in the neonatal period than any other time in life; however, it is still a challenge for the evidence based diagnosis. Strategy for identification of neonatal bacterial meni...

    Authors: Yajuan Wang, Gaili Guo, Huixin Wang, Xuefang Yang, Fang Shao, Caiyun Yang, Wei Gao, Zhujun Shao, Jinjing Zhang, Jie Luo, Yonghong Yang, Fanrong Kong and Bingqing Zhu

    Citation: BMC Pediatrics 2014 14:224

    Content type: Research article

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  8. Pathogenesis of intraventricular hemorrhage (IVH) in premature infants is multifactorial. Little is known about the impact of genetic variants in the vitamin K-dependent coagulation system on the development o...

    Authors: Christine Schreiner, Sévérine Suter, Matthias Watzka, Hans-Jörg Hertfelder, Felix Schreiner, Johannes Oldenburg, Peter Bartmann and Axel Heep

    Citation: BMC Pediatrics 2014 14:219

    Content type: Research article

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  9. It is now recognized that preterm infants ≤28 weeks gestation can be effectively supported from the outset with nasal continuous positive airway pressure. However, this form of respiratory therapy may fail to ...

    Authors: Peter A Dargaville, Camille Omar F Kamlin, Antonio G De Paoli, John B Carlin, Francesca Orsini, Roger F Soll and Peter G Davis

    Citation: BMC Pediatrics 2014 14:213

    Content type: Study protocol

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  10. The mitochondrial m.1555A>G mutation is associated with a high rate of permanent hearing loss, if aminoglycosides are given. Preterm infants have an increased risk of permanent hearing loss and are frequently ...

    Authors: Wolfgang Göpel, Sandra Berkowski, Michael Preuss, Andreas Ziegler, Helmut Küster, Ursula Felderhoff-Müser, Ludwig Gortner, Michael Mögel, Christoph Härtel and Egbert Herting

    Citation: BMC Pediatrics 2014 14:210

    Content type: Research article

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  11. Little evidence exists regarding the optimal concentration of oxygen to use in the treatment of term neonates with spontaneous pneumothorax (SP). The practice of using high oxygen concentrations to promote “ni...

    Authors: Huma Shaireen, Yacov Rabi, Amy Metcalfe, Majeeda Kamaluddeen, Harish Amin, Albert Akierman and Abhay Lodha

    Citation: BMC Pediatrics 2014 14:208

    Content type: Research article

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  12. Brain-water content (BWC) decreases with maturation of the brain and potentially affects parameters of cerebral oxygenation determined by near-infrared spectroscopy (NIRS). Most commercially available devices ...

    Authors: Anja Demel, Martin Wolf, Christian F Poets and Axel R Franz

    Citation: BMC Pediatrics 2014 14:206

    Content type: Research article

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  13. Vancomycin is effective against gram-positive bacteria and the first-line antibiotic for treatment of proven coagulase-negative staphylococcal infections. The aim of this study is bipartite: first, to assess t...

    Authors: Fleur S Sinkeler, Timo R de Haan, Caspar J Hodiamont, Yuma A Bijleveld, Dasja Pajkrt and Ron A A Mathôt

    Citation: BMC Pediatrics 2014 14:193

    Content type: Research article

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  14. In Sub-Saharan Africa over one million newborns die annually. We developed a sustainable and scalable home-based counselling intervention for delivery by community volunteers in rural southern Tanzania to impr...

    Authors: Suzanne Penfold, Fatuma Manzi, Elibariki Mkumbo, Silas Temu, Jennie Jaribu, Donat D Shamba, Hassan Mshinda, Simon Cousens, Tanya Marchant, Marcel Tanner, David Schellenberg and Joanna Armstrong Schellenberg

    Citation: BMC Pediatrics 2014 14:187

    Content type: Research article

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  15. Perinatal stroke is a leading cause of early brain injury, cerebral palsy, and lifelong neurological morbidity. No study to date has examined the impact of raising a child with perinatal stroke on parents and ...

    Authors: Taryn B Bemister, Brian L Brooks, Richard H Dyck and Adam Kirton

    Citation: BMC Pediatrics 2014 14:182

    Content type: Research article

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  16. In many resource-limited settings, the availability of effective phototherapy for jaundiced infants is frequently hampered by lack of, or inadequate resources to acquire and maintain conventional electric-powe...

    Authors: Bolajoko O Olusanya, Zainab O Imam, Cecilia A Mabogunje, Abieyuwa A Emokpae and Tina M Slusher

    Citation: BMC Pediatrics 2014 14:180

    Content type: Research article

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  17. Fetal alcohol spectrum disorder (FASD) is known to be under-recognised in Australia. The use of standard methods to identify when to refer individuals who may have FASD for specialist assessment could help imp...

    Authors: Rochelle E Watkins, Elizabeth J Elliott, Amanda Wilkins, Jane Latimer, Jane Halliday, James P Fitzpatrick, Raewyn C Mutch, Colleen M O’Leary, Lucinda Burns, Anne McKenzie, Heather M Jones, Janet M Payne, Heather D’Antoine, Sue Miers, Elizabeth Russell, Lorian Hayes…

    Citation: BMC Pediatrics 2014 14:178

    Content type: Research article

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  18. Despite therapeutic hypothermia 30-70% of newborns with moderate or severe hypoxic ischemic encephalopathy will die or survive with significant long-term impairments. Magnetic resonance imaging (MRI) in the fi...

    Authors: Thais Agut, Marisol León, Mónica Rebollo, Jordi Muchart, Gemma Arca and Alfredo Garcia-Alix

    Citation: BMC Pediatrics 2014 14:177

    Content type: Research article

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  19. The INtubation-SURfactant-Extubation (INSURE) is a procedure that is increasingly being used to treat the respiratory distress syndrome in preterm infants. The objective of this study was to identify predictor...

    Authors: Nis Brix, Anna Sellmer, Morten Søndergaard Jensen, Linda Vad Pedersen and Tine Brink Henriksen

    Citation: BMC Pediatrics 2014 14:155

    Content type: Research article

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  20. Kasabach-Merritt syndrome (KMS) is characterized by giant hemangiomas and severe thrombocytopenia, which may result in life-threatening multi-organ hemorrhage. This study evaluated the clinical characteristics...

    Authors: Ping Wang, Wei Zhou, Li Tao, Ning Zhao and Xiao-Wen Chen

    Citation: BMC Pediatrics 2014 14:146

    Content type: Research article

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  21. Deferring cord clamping at very preterm births may be beneficial for babies. However, deferring cord clamping should not mean that newborn resuscitation is deferred. Providing initial care at birth at the moth...

    Authors: Margaret R Thomas, Charles W Yoxall, Andrew D Weeks and Lelia Duley

    Citation: BMC Pediatrics 2014 14:135

    Content type: Research article

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  22. Managing the oxygen saturation of preterm infants to a target range has been the standard of care for a decade. Changes in target ranges have been shown to significantly impact mortality and morbidity. Selecti...

    Authors: Maria Wilinska, Thomas Bachman, Janusz Swietlinski, Maria Kostro and Marta Twardoch-Drozd

    Citation: BMC Pediatrics 2014 14:130

    Content type: Research article

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  23. Congenital grouped skin lesions are alarming signs of a variety of threatening diagnoses of quite different origin. The present case report shows an impressive clinical pattern of a neonate and illustrates the...

    Authors: Michaela Döring, Karin Melanie Rohrer, Ilias Tsiflikas, Wolfgang Buchenau, Marko Wilke, Rupert Handgretinger, Christian Friedrich Poets and Rangmar Goelz

    Citation: BMC Pediatrics 2014 14:126

    Content type: Case report

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  24. Invasive methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-sensitive Staphylococcus aureus (MSSA) infections are major causes of numerous neonatal intensive care unit (NICU) outbreaks. There have...

    Authors: Olajide Dolapo, Ramasubbareddy Dhanireddy and Ajay J Talati

    Citation: BMC Pediatrics 2014 14:121

    Content type: Research article

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  25. Premedication before neonatal intubation is heterogeneous and contentious. The combination of a short acting, rapid onset opioid with a muscle relaxant is considered suitable by many experts. The purpose of th...

    Authors: Xavier Durrmeyer, Sonia Dahan, Pierre Delorme, Sabine Blary, Gilles Dassieu, Laurence Caeymaex and Ricardo Carbajal

    Citation: BMC Pediatrics 2014 14:120

    Content type: Research article

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  26. Infants born <30 weeks’ gestation are at increased risk of long term neurodevelopmental problems compared with term born peers. The predictive value of neurobehavioural examinations at term equivalent age in v...

    Authors: Alicia J Spittle, Deanne K Thompson, Nisha C Brown, Karli Treyvaud, Jeanie LY Cheong, Katherine J Lee, Carmen C Pace, Joy Olsen, Leesa G Allinson, Angela T Morgan, Marc Seal, Abbey Eeles, Fiona Judd, Lex W Doyle and Peter J Anderson

    Citation: BMC Pediatrics 2014 14:111

    Content type: Study protocol

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  27. The International Network for Evaluating Outcomes in Neonates (iNeo) is a collaboration of population-based national neonatal networks including Australia and New Zealand, Canada, Israel, Japan, Spain, Sweden,...

    Authors: Prakesh S Shah, Shoo K Lee, Kei Lui, Gunnar Sjörs, Rintaro Mori, Brian Reichman, Stellan Håkansson, Laura San Feliciano, Neena Modi, Mark Adams, Brian Darlow, Masanori Fujimura, Satoshi Kusuda, Ross Haslam and Lucia Mirea

    Citation: BMC Pediatrics 2014 14:110

    Content type: Study protocol

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  28. To better understand factors that may impact infant mortality rates (IMR), we evaluated the consistency across birth hospitals in the classification of a birth event as either a fetal death or an early neonata...

    Authors: Charles R Woods, Deborah Winders Davis, Scott D Duncan, John A Myers and Thomas Michael O’Shea

    Citation: BMC Pediatrics 2014 14:108

    Content type: Research article

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  29. Extended spectrum beta-lactamase-producing Klebsiella pneumoniae (ESBL-Kp) infection can cause significant morbidity and mortality in neonates. We investigated a nosocomial ESBL-Kp outbreak in a neonatal intensiv...

    Authors: Angeliki Mavroidi, Apostolos Liakopoulos, Antonios Gounaris, Maria Goudesidou, Katerina Gaitana, Vivi Miriagou and Efthymia Petinaki

    Citation: BMC Pediatrics 2014 14:105

    Content type: Research article

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  30. We estimate the effect of antibiotics given in the intrapartum period on early-onset neonatal sepsis in Dhaka, Bangladesh using propensity score techniques.

    Authors: Grace J Chan, Elizabeth A Stuart, Marzia Zaman, Abdullah A Mahmud, Abdullah H Baqui and Robert E Black

    Citation: BMC Pediatrics 2014 14:104

    Content type: Research article

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  31. Children born at low gestational ages face a range of risks and number of neonates surviving very preterm birth is increasing. We present the objectives and methods of a French national cohort of very and mode...

    Authors: Pierre-Yves Ancel and François Goffinet

    Citation: BMC Pediatrics 2014 14:97

    Content type: Study protocol

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  32. Magnetic resonance imaging (MRI) is a useful tool to study brain growth and organization in preterm neonates for clinical and research purposes, but its practicality can be limited by time and medical constrai...

    Authors: Nathalie L Maitre, James C Slaughter, Ann R Stark, Judy L Aschner and Adam W Anderson

    Citation: BMC Pediatrics 2014 14:84

    Content type: Technical advance

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  33. Preterm infants are at risk for adverse neurodevelopment. Furthermore, nutrition may play a key role in supporting neurodevelopment. The aim of this study was to evaluate whether a nutrient-enriched formula fe...

    Authors: Maria Lorella Giannì, Paola Roggero, Orsola Amato, Odoardo Picciolini, Pasqua Piemontese, Nadia Liotto, Francesca Taroni and Fabio Mosca

    Citation: BMC Pediatrics 2014 14:74

    Content type: Research article

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  34. B-type natriuretic peptide (BNP) is a strong predictor of mortality in adult patients with various forms of pulmonary hypertension (PH) and may be a strong prognostic marker in extremely low birth weight (ELBW...

    Authors: Alain Cuna, Jegen Kandasamy and Brian Sims

    Citation: BMC Pediatrics 2014 14:68

    Content type: Research article

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  35. Hearing loss in children born before 32 weeks of gestation is more prevalent than in full term infants. Aminoglycoside antibiotics are routinely used to treat bacterial infections in babies on neonatal intensi...

    Authors: Maria Bitner-Glindzicz, Shamima Rahman, Kathy Chant and Neil Marlow

    Citation: BMC Pediatrics 2014 14:66

    Content type: Study protocol

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  36. We examined the quality of the information on the use of surfactant and the use of and duration of nasal continuous positive airway pressure (nCPAP), oxygen supplementation, and mechanical ventilation in the D...

    Authors: Sofia Andersson, Jesper Padkær Petersen, Tine Brink Henriksen and Finn Ebbesen

    Citation: BMC Pediatrics 2014 14:47

    Content type: Research article

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  37. An understanding of perceptions of parents and health caregivers who assist critically ill neonates is necessary to comprehend their actions and demands. Therefore this study aim to analyze the agreement among...

    Authors: Luciana Sabatini Doto Tannous Elias, Amélia Miyashiro Nunes dos Santos and Ruth Guinsburg

    Citation: BMC Pediatrics 2014 14:44

    Content type: Research article

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  38. Sustained inflations (SI) are advocated for the rapid establishment of FRC after birth in preterm and term infants requiring resuscitation. However, the most appropriate way to deliver a SI is poorly understoo...

    Authors: Graeme R Polglase, David G Tingay, Risha Bhatia, Clare A Berry, Robert J Kopotic, Clinton P Kopotic, Yong Song, Edgardo Szyld, Alan H Jobe and Jane J Pillow

    Citation: BMC Pediatrics 2014 14:43

    Content type: Research article

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  39. Delivery room management (DR) of the newly born infant should be performed according to international guidelines, but no recommendations are available for an infant’s position immediately after birth. The pres...

    Authors: Dimitrios Konstantelos, Heidrun Gurth, Renate Bergert, Sascha Ifflaender and Mario Rüdiger

    Citation: BMC Pediatrics 2014 14:33

    Content type: Research article

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  40. Newborns delivered by vacuum extraction quite often show clinical signs of a hemodynamic compromise, which is difficult to assess in terms of severity. The conventional means to measure the hemodynamic status ...

    Authors: Tanja Karen, Martin Wolf, Rahel Nef, Daniel Haensse, Hans Ulrich Bucher, Gabriele Schulz and Jean-Claude Fauchère

    Citation: BMC Pediatrics 2014 14:21

    Content type: Research article

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  41. Bronchopulmonary dysplasia (BPD) is a common complication of preterm birth. Very different models using clinical parameters at an early postnatal age to predict BPD have been developed with little extensive qu...

    Authors: Wes Onland, Thomas P Debray, Matthew M Laughon, Martijn Miedema, Filip Cools, Lisa M Askie, Jeanette M Asselin, Sandra A Calvert, Sherry E Courtney, Carlo Dani, David J Durand, Neil Marlow, Janet L Peacock, J Jane Pillow, Roger F Soll, Ulrich H Thome…

    Citation: BMC Pediatrics 2013 13:207

    Content type: Research article

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  42. Early interventions (EI) are recognised for their potential risk-reduction capacity. Although developmental delay is common in children born very preterm reports continue to suggest poor uptake of EI services....

    Authors: Margo A Pritchard, Paul B Colditz, David Cartwright, Peter H Gray, David Tudehope and Elaine Beller

    Citation: BMC Pediatrics 2013 13:201

    Content type: Research article

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  43. Mild rectal bleeding (MRB) is a particular clinical entity different from necrotizing enterocolitis, which significantly influences neonatal care in preterm infants. We aimed to determine the risk factors and ...

    Authors: Abdallah Oulmaati, Stephane Hays, Mohamed Ben Said, Delphine Maucort-Boulch, Isabelle Jordan and Jean-Charles Picaud

    Citation: BMC Pediatrics 2013 13:196

    Content type: Research article

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  44. Amplitude-integrated electroencephalography (aEEG) is a useful tool to determine the severity of neonatal hypoxic-ischemic encephalopathy (HIE). Our aim was to assess the prevalence and study the origin of fal...

    Authors: Gábor Marics, Anna Csekő, Barna Vásárhelyi, Dávid Zakariás, György Schuster and Miklós Szabó

    Citation: BMC Pediatrics 2013 13:194

    Content type: Research article

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  45. Skin-to-skin contact (SSC) between mother and infant, commonly referred to as Kangaroo Mother Care (KMC), is recommended as an intervention for procedural pain. Evidence demonstrates its consistent efficacy in...

    Authors: Marsha Campbell-Yeo, Celeste Johnston, Britney Benoit, Margot Latimer, Michael Vincer, Claire-Dominique Walker, David Streiner, Darlene Inglis and Kim Caddell

    Citation: BMC Pediatrics 2013 13:182

    Content type: Study protocol

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