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Neonatology

Section edited by Elizabeth Asztalos

This section considers studies regarding all aspects of neonatal health, disease, care, and outcomes.

Page 4 of 8

  1. Feeding breast milk is associated with reduced morbidity and mortality, as well as improved neurodevelopmental outcome but does not meet the high nutritional requirements of preterm infants. Both plasma and ur...

    Authors: Michaela Mathes, Christoph Maas, Christine Bleeker, Julia Vek, Wolfgang Bernhard, Andreas Peter, Christian F. Poets and Axel R. Franz

    Citation: BMC Pediatrics 2018 18:154

    Content type: Research article

    Published on:

  2. Inhaled corticosteroids (ICS) offer targeted treatment for bronchopulmonary dysplasia (BPD) with minimal systemic effects compared to systemic steroids. However, dosing of ICS in the management of infants at h...

    Authors: Kamini Raghuram, Michael Dunn, Krista Jangaard, Maureen Reilly, Elizabeth Asztalos, Edmond Kelly, Michael Vincer and Vibhuti Shah

    Citation: BMC Pediatrics 2018 18:153

    Content type: Research article

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  3. There is increasing evidence that neonatal seizures in term neonates with stroke, asphyxia or brain haemorrhage might be associated with adverse neurodevelopment and development of epilepsy. The extent of this...

    Authors: T. R. De Haan, J. Langeslag, J. H. van der Lee and A. H. van Kaam

    Citation: BMC Pediatrics 2018 18:147

    Content type: Research article

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  4. The point prevalence of Clostridium difficile stool shedding in hospitalized infants from two neonatal intensive care units (NICUs) was examined utilizing standard clinical testing compared with duplex PCR to ide...

    Authors: Andrea Green Hines, Alison Freifeld, Xing Zhao, Ann Anderson Berry, Lynne Willett, Peter C. Iwen and Kari A. Simonsen

    Citation: BMC Pediatrics 2018 18:137

    Content type: Research article

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  5. Infants in Neonatal Intensive Care Units represent a heavily transfused population, and are the focus of much research interest. Such research commonly relies on custom research databases or routinely collecte...

    Authors: Jillian A. Patterson, Jennifer R. Bowen, Sally Francis and Jane B. Ford

    Citation: BMC Pediatrics 2018 18:86

    Content type: Research article

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  6. Orally administered sucrose is effective and safe in reducing pain intensity during single, tissue-damaging procedures in neonates, and is commonly recommended in neonatal pain guidelines. However, there is wi...

    Authors: Bonnie Stevens, Janet Yamada, Marsha Campbell-Yeo, Sharyn Gibbins, Denise Harrison, Kimberley Dionne, Anna Taddio, Carol McNair, Andrew Willan, Marilyn Ballantyne, Kimberley Widger, Souraya Sidani, Carole Estabrooks, Anne Synnes, Janet Squires, Charles Victor…

    Citation: BMC Pediatrics 2018 18:85

    Content type: Research article

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  7. In critically ill (preterm) neonates, central venous catheters (CVCs) are increasingly used for administration of medication or parenteral nutrition. A serious complication, however, is the development of cath...

    Authors: Jeanine J. Sol, Moniek van de Loo, Marit Boerma, Klasien A. Bergman, Albertine E. Donker, Mark A. H. B. M. van der Hoeven, Christiaan V. Hulzebos, Ronny Knol, K. Djien Liem, Richard A. van Lingen, Enrico Lopriore, Monique H. Suijker, Daniel C. Vijlbrief, Remco Visser, Margreet A. Veening, Mirjam M. van Weissenbruch…

    Citation: BMC Pediatrics 2018 18:84

    Content type: Study protocol

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  8. Therapeutic hypothermia is neuroprotective in asphyxiated neonates by counteracting mechanisms contributing to brain injury. Although an initial increased permeability is part of an inflammatory reaction and t...

    Authors: Hans Jørgen Timm Guthe, Torbjørn Nedrebø, Jan Kristian Damås, Helge Wiig and Ansgar Berg

    Citation: BMC Pediatrics 2018 18:82

    Content type: Research article

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  9. In the last 20 years, the chances for intact survival for extremely preterm infants have increased in high income countries. Decisions about withholding or withdrawing intensive care remain a major challenge i...

    Authors: Hans Ulrich Bucher, Sabine D. Klein, Manya J. Hendriks, Ruth Baumann-Hölzle, Thomas M. Berger, Jürg C. Streuli and Jean-Claude Fauchère

    Citation: BMC Pediatrics 2018 18:81

    Content type: Research article

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    The Correction to this article has been published in BMC Pediatrics 2020 20:47

    The Correction to this article has been published in BMC Pediatrics 2018 18:226

  10. What constitutes a hemodynamically relevant patent ductus arteriosus (hrPDA) in preterm infants is unclear. Different clinical and echocardiographic parameters are used, but a gold standard definition is lacking.

    Authors: Christoph E. Schwarz, Antonio Preusche, Martin Wolf, Christian F. Poets and Axel R. Franz

    Citation: BMC Pediatrics 2018 18:66

    Content type: Research article

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  11. To explore the associations between histologic chorioamnionitis with brain injury, maturation and size on magnetic resonance imaging (MRI) of preterm infants at term equivalent age.

    Authors: Claire Granger, Alicia J. Spittle, Jennifer Walsh, Jan Pyman, Peter J. Anderson, Deanne K. Thompson, Katherine J. Lee, Lee Coleman, Charuta Dagia, Lex W. Doyle and Jeanie Cheong

    Citation: BMC Pediatrics 2018 18:63

    Content type: Research article

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  12. Neonatal nonoliguric hyperkalemia (NOHK) is a metabolic abnormality that occurs in extremely premature neonates at approximately 24 h after birth and is mainly due to the immature functioning of the sodium (Na+)/...

    Authors: Kenichi Tanaka, Hiroko Mori, Rieko Sakamoto, Shirou Matsumoto, Hiroshi Mitsubuchi, Kimitoshi Nakamura and Masanori Iwai

    Citation: BMC Pediatrics 2018 18:55

    Content type: Case report

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  13. When breastfeeding is not possible, infants are fed formulas (IF) in which lipids are usually of plant origin. However, the use of dairy fat in combination with plant oils enables a lipid profile closer to bre...

    Authors: Maria Lorella Gianni, Paola Roggero, Charlotte Baudry, Catherine Fressange-Mazda, Claudio Galli, Carlo Agostoni, Pascale le Ruyet and Fabio Mosca

    Citation: BMC Pediatrics 2018 18:53

    Content type: Research article

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  14. Skin to skin contact (SSC) at birth is the standard of care for newborns without risk factors. However, implementation of SSC at birth has been far from optimal. A qualitative study was undertaken to determine...

    Authors: Amala James Alenchery, Joanne Thoppil, Carl Denis Britto, Jimena Villar de Onis, Lavina Fernandez and P. N. Suman Rao

    Citation: BMC Pediatrics 2018 18:48

    Content type: Research article

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  15. Double gallbladder is a rare biliary anomaly. Perinatal diagnosis of the disorder has been reported in only 6 cases, and in 5 of them the diagnosis was based on ultrasound imaging only. However, the ultrasound...

    Authors: Umberto Maggi, Giorgio Farris, Alessandra Carnevali, Irene Borzani, Paola Clerici, Massimo Agosti, Giorgio Rossi and Ernesto Leva

    Citation: BMC Pediatrics 2018 18:38

    Content type: Case report

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  16. Late-onset sepsis in very low birth weight (VLBW) infants is a diagnostic challenge. We aimed to evaluate the diagnostic utility of the C-Reactive protein (CRP) and the complete blood count (CBC) for late-onse...

    Authors: Marc Beltempo, Isabelle Viel-Thériault, Roseline Thibeault, Anne-Sophie Julien and Bruno Piedboeuf

    Citation: BMC Pediatrics 2018 18:16

    Content type: Research article

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  17. When breastfeeding is not possible, infants are fed formulas in which lipids are usually of plant origin. However, the use of dairy fat in combination with plant oils enables a lipid profile in formula closer ...

    Authors: Maria Lorella Gianni, Paola Roggero, Charlotte Baudry, Catherine Fressange-Mazda, Pascale le Ruyet and Fabio Mosca

    Citation: BMC Pediatrics 2018 18:10

    Content type: Research article

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  18. Intramuscular vitamin A supplementation decreases the risk of bronchopulmonary dysplasia (BPD) in very-low-birth-weight preterm infants without significant adverse effects. However, intramuscular vitamin A sup...

    Authors: Abhijeet Rakshasbhuvankar, Sanjay Patole, Karen Simmer and J. Jane Pillow

    Citation: BMC Pediatrics 2017 17:204

    Content type: Study protocol

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  19. Hyperbilirubinaemia is a major cause of neonatal morbidity. Early identification of those infants most at risk might allow the development of targeted primary preventative therapy and follow-up. The objective ...

    Authors: Kelsey D. J. Jones, S E. Grossman, Dharshini Kumaranayakam, Arati Rao, Greg Fegan and Narendra Aladangady

    Citation: BMC Pediatrics 2017 17:186

    Content type: Research article

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  20. The Bernese Pain Scale for Neonates (BPSN) is a multidimensional pain assessment tool that is already widely used in clinical settings in the German speaking areas of Europe. Recent findings indicate that pain...

    Authors: Eva Cignacco, Karin Schenk, Bonnie Stevens, Liliane Stoffel, Dirk Bassler, Sven Schulzke and Mathias Nelle

    Citation: BMC Pediatrics 2017 17:171

    Content type: Study protocol

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  21. Extremely preterm infants (≤ 28 weeks gestation) commonly require endotracheal intubation and mechanical ventilation (MV) to maintain adequate oxygenation and gas exchange. Given that MV is independently assoc...

    Authors: Wissam Shalish, Lara J. Kanbar, Smita Rao, Carlos A. Robles-Rubio, Lajos Kovacs, Sanjay Chawla, Martin Keszler, Doina Precup, Karen Brown, Robert E. Kearney and Guilherme M. Sant’Anna

    Citation: BMC Pediatrics 2017 17:167

    Content type: Study protocol

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  22. Compared to very low gestational age (<32 weeks, VLGA) cohorts, very low birth weight (<1500 g; VLBW) cohorts are more prone to selection bias toward small-for-gestational age (SGA) infants, which may impact u...

    Authors: Louise IM Koller-Smith, Prakesh S. Shah, Xiang Y. Ye, Gunnar Sjörs, Yueping A. Wang, Sharon S. W. Chow, Brian A. Darlow, Shoo K. Lee, Stellan Håkanson and Kei Lui

    Citation: BMC Pediatrics 2017 17:166

    Content type: Research article

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  23. Retinopathy of prematurity (ROP) still represents one of the leading causes of visual impairment in childhood. Systemic propranolol has proven to be effective in reducing ROP progression in preterm newborns, a...

    Authors: Luca Filippi, Giacomo Cavallaro, Elettra Berti, Letizia Padrini, Gabriella Araimo, Giulia Regiroli, Valentina Bozzetti, Chiara De Angelis, Paolo Tagliabue, Barbara Tomasini, Giuseppe Buonocore, Massimo Agosti, Angela Bossi, Gaetano Chirico, Salvatore Aversa, Roberta Pasqualetti…

    Citation: BMC Pediatrics 2017 17:165

    Content type: Study protocol

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  24. Approximately 8–23% of premature infants develop pulmonary hypertension (PH), and this diagnosis confers a higher possibility of mortality. As a result, professional societies recommend PH screening in prematu...

    Authors: Shilpa Vyas-Read, Usama Kanaan, Prabhu Shankar, Jane Stremming, Curtis Travers, David P. Carlton and Anne Fitzpatrick

    Citation: BMC Pediatrics 2017 17:163

    Content type: Research article

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  25. Neonatal mortality accounts for nearly three quarters of all infant deaths in Vietnam. The nursing team are the largest professional group working with newborns, however do not routinely receive neonatal train...

    Authors: Katie Gallagher, Colin Partridge, Hoang T Tran, Suzanna Lubran and Duncan Macrae

    Citation: BMC Pediatrics 2017 17:161

    Content type: Research article

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  26. The use of cord blood in the neonatal screening for glucose-6-phosphate dehydrogenase (G6PD) deficiency is being done with increasing frequency but has yet to be adequately evaluated against the use of periphe...

    Authors: Saif AlSaif, Ma. Bella Ponferrada, Khalid AlKhairy, Khalil AlTawil, Adel Sallam, Ibrahim Ahmed, Mohammed Khawaji, Khalid AlHathlol, Beverly Baylon, Ahmed AlSuhaibani and Mohammed AlBalwi

    Citation: BMC Pediatrics 2017 17:159

    Content type: Research article

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  27. Complications during pregnancy, childbirth and/or the postnatal period may result in the admission of a baby to a neonatal unit (NNU). While the survival and long-term prospects of high-risk infants are enhanc...

    Authors: Susan Kerr, Caroline King, Rhona Hogg, Kerri McPherson, Janet Hanley, Maggie Brierton and Sean Ainsworth

    Citation: BMC Pediatrics 2017 17:158

    Content type: Research article

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  28. According to WHO (2013) report the number of under five-year mortality in Ethiopia was 195,504, out of this 84,437 was from neonatal death and this mortality is related to immediate obstetric and newborn care ...

    Authors: Abadi Kidanemariam Berhe, Fitiwi Tinsae and Gebremedhin Gebreegziabher

    Citation: BMC Pediatrics 2017 17:157

    Content type: Research article

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  29. Infant birth weight, which is classified into low birth weight, normal birth weight and macrosomia, is associated with short and long-term health consequences, such as neonatal mortality and chronic disease in...

    Authors: Hayelom Gebrekirstos Mengesha, Alem Desta Wuneh, Berhe Weldearegawi and Divya L. Selvakumar

    Citation: BMC Pediatrics 2017 17:144

    Content type: Research article

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  30. Hypoxic Ischemic Encephalopathy (HIE) remains a problem of great concern worldwide especially in developing countries. The occurrence of a neurological syndrome can be an indicator of insult to the brain. We a...

    Authors: Irene N. Simiyu, Deborah N. Mchaile, Kahindo Katsongeri, Rune N. Philemon and Sia E. Msuya

    Citation: BMC Pediatrics 2017 17:131

    Content type: Research article

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  31. There are conflicting results in the literature on the impact of chorioamnionitis on neonatal respiratory morbidities. However, most studies are based on small clinical samples and fail to account for the comp...

    Authors: Amy Metcalfe, Sarka Lisonkova, Yasser Sabr, Amelie Stritzke and KS Joseph

    Citation: BMC Pediatrics 2017 17:128

    Content type: Research article

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  32. Early identification of infants at higher risk of developing bronchopulmonary dysplasia (BPD) may enable a targeted approach to reduce BPD. We aimed to evaluate the hypothesis that the interstitial pneumonia p...

    Authors: Hye-Rim Kim, Ji Young Kim, Bo La Yun, Byoungkook Lee, Chang Won Choi and Beyong Il Kim

    Citation: BMC Pediatrics 2017 17:125

    Content type: Research article

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  33. Low birth weight (Birth weight < 2500 g) is a leading cause of prenatal and neonatal deaths. The early identification of Low birth weight (LBW) neonates is essential for any comprehensive initiative to improve...

    Authors: Marta Yemane Hadush, Amanuel Hadgu Berhe and Araya Abrha Medhanyie

    Citation: BMC Pediatrics 2017 17:111

    Content type: Research article

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  34. Necrotizing enterocolitis (NEC) is a severe multifactorial disease in preterm neonates associated with high morbidity and mortality. Better insight into prognostic values of the many reported factors associate...

    Authors: Noor Samuels, Rob A. van de Graaf, Rogier C. J. de Jonge, Irwin K. M. Reiss and Marijn J. Vermeulen

    Citation: BMC Pediatrics 2017 17:105

    Content type: Research article

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  35. Each year 700,000 infants die due to intrapartum-related complications. Implementation of Helping Babies Breathe (HBB)-a simplified neonatal resuscitation protocol in low-resource clinical settings has shown t...

    Authors: Ashish KC, Johan Wrammert, Viktoria Nelin, Robert B. Clark, Uwe Ewald, Stefan Peterson and Mats Målqvist

    Citation: BMC Pediatrics 2017 17:103

    Content type: Research article

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  36. Neonatal hyperbilirubinemia has traditionally been screened by either total serum bilirubin or transcutaneous bilirubin. Whole blood bilirubin (TwB) by the GEM Premier 4000® blood gas analyzer (GEM) is a relat...

    Authors: Li Wang, Arianne Y. K. Albert, Benjamin Jung, Keyvan Hadad, Martha E. Lyon and Melanie Basso

    Citation: BMC Pediatrics 2017 17:92

    Content type: Research article

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  37. Previous studies have indicated edema may be involved in the pathophysiology following hypoxic-ischemic encephalopathy (HIE), and melatonin may exhibit neuro-protection against brain insults. However, little i...

    Authors: Li-Xiao Xu, Yuan Lv, Yan-Hong Li, Xin Ding, Ying Wang, Xing Han, Ming-Hua Liu, Bin Sun and Xing Feng

    Citation: BMC Pediatrics 2017 17:90

    Content type: Research article

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  38. In newborns and children, body fat estimation equations are often used at different ages than the age used to develop the equations. Limited validation studies exist for newborn body fat estimation equations a...

    Authors: Jennifer S. Cauble, Mira Dewi and Holly R. Hull

    Citation: BMC Pediatrics 2017 17:88

    Content type: Research article

    Published on:

    The Correction to this article has been published in BMC Pediatrics 2020 20:92

  39. Some infants with congenital heart disease are at risk of in-hospital cardiac arrest. To better foresee cardiac arrest in infants with congenital heart disease, it might be useful to continuously assess end-or...

    Authors: Mirthe J. Mebius, Gideon J. du Marchie Sarvaas, Diana W. Wolthuis, Beatrijs Bartelds, Martin C. J. Kneyber, Arend F. Bos and Elisabeth M. W. Kooi

    Citation: BMC Pediatrics 2017 17:79

    Content type: Case report

    Published on:

  40. Some etiological factors involved in developmental dysplasia of the hip (DDH) occur in the last trimester of pregnancy, which could result in a decreased incidence of DDH in preterm infants. The aim of this st...

    Authors: A. E. Lange, J. Lange, Till Ittermann, M. Napp, Paul-Christian Krueger, H. Bahlmann, R. Kasch and M. Heckmann

    Citation: BMC Pediatrics 2017 17:78

    Content type: Research article

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  41. While there are good data to describe changing trends in mortality and morbidity rates for preterm populations, there is very little information on the specific causes and pattern of death in terms of age of v...

    Authors: Tim Schindler, Louise Koller-Smith, Kei Lui, Barbara Bajuk and Srinivas Bolisetty

    Citation: BMC Pediatrics 2017 17:59

    Content type: Research article

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  42. Vancomycin has recently gained popularity as an empiric therapy for late onset sepsis in the NICU. Changes in resistance patterns in common organisms has resulted in targeting higher trough concentrations of v...

    Authors: Vidit Bhargava, Michael Malloy and Rafael Fonseca

    Citation: BMC Pediatrics 2017 17:50

    Content type: Research article

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  43. Handling neonates with postnatal respiratory failure due to congenital airway malformations implies knowledge about emergency management of unexpected difficult airway. In these stressful situations both techn...

    Authors: Beate Grass, Leopold Simma, Michael Reinehr, Urs Zimmermann, Claudine Gysin, Georg Henze and Vincenzo Cannizzaro

    Citation: BMC Pediatrics 2017 17:49

    Content type: Case report

    Published on:

  44. In the UK, 1–2% of infants are born very preterm (<32 weeks of gestation) or have very low birth weight (<1500 g). Very preterm infants are initially unable to be fed nutritional volumes of milk and therefore ...

    Authors: Jane Abbott, Janet Berrington, Ursula Bowler, Elaine Boyle, Jon Dorling, Nicholas Embleton, Edmund Juszczak, Alison Leaf, Louise Linsell, Samantha Johnson, Kenny McCormick, William McGuire, Tracy Roberts and Ben Stenson

    Citation: BMC Pediatrics 2017 17:39

    Content type: Study protocol

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  45. Preterm neonates undergo many painful procedures as part of their standard care in the neonatal intensive care unit. However, pain treatment is inadequate in many of these routine procedures. In the present st...

    Authors: Jie Qiu, Yun-fei Jiang, Fang Li, Qian-hong Tong, Hui Rong and Rui Cheng

    Citation: BMC Pediatrics 2017 17:38

    Content type: Research article

    Published on: