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Neonatology

Section edited by Elizabeth Asztalos

This section considers studies regarding all aspects of neonatal health, disease, care, and outcomes.

Page 3 of 8

  1. Assessing pain in neonates is challenging because full-term and preterm neonates of different gestational ages (GAs) have widely varied reactions to pain. We validated the Bernese Pain Scale for Neonates (BPSN...

    Authors: Karin Schenk, Liliane Stoffel, Reto Bürgin, Bonnie Stevens, Dirk Bassler, Sven Schulzke, Mathias Nelle and Eva Cignacco

    Citation: BMC Pediatrics 2019 19:20

    Content type: Research article

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  2. Substantial numbers of neonates with hypoxic respiratory failure (HRF) do not immediately respond to inhaled nitric oxide (iNO) and are often labeled as non-responders. This retrospective data analysis assesse...

    Authors: Leif D. Nelin and Jim L. Potenziano

    Citation: BMC Pediatrics 2019 19:17

    Content type: Research article

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  3. Although therapeutic hypothermia improves the outcome of neonatal hypoxic-ischemic encephalopathy (HIE), its efficacy is still limited. This preliminary study evaluates the safety and feasibility of the combin...

    Authors: Miho Nonomura, Sayaka Harada, Yuki Asada, Hisako Matsumura, Hiroko Iwami, Yuko Tanaka and Hiroyuki Ichiba

    Citation: BMC Pediatrics 2019 19:13

    Content type: Research article

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  4. Many newborns may need to be hospitalized and receive drugs during the first days of their lives. These drugs are fundamentally prescribed as off-label and unlicensed. This study aimed to investigate the amoun...

    Authors: Leila Kouti, Maryam Aletayeb, Seyyed Mohammad Hassan Aletayeb, Amir Kamal Hardani and Kaveh Eslami

    Citation: BMC Pediatrics 2019 19:3

    Content type: Research article

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  5. Recent National Institute for Health and Care Excellence (NICE) CG149 guidelines suggest considering performing a lumbar puncture (LP) to investigate for meningitis in early-onset sepsis in a neonate when a C-...

    Authors: Jonathan P. Sturgeon, Beatrice Zanetti and Dwight Lindo

    Citation: BMC Pediatrics 2018 18:380

    Content type: Research article

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  7. Necrotizing enterocolitis (NEC) is a leading cause of death in preterm infants. Neonates weighing <1500 grams are at the highest risk for acquiring NEC, with a prevalence of nearly 7-10%, mortality up to 30%, ...

    Authors: Srikanth Ravisankar, Rodney Tatum, Parvesh M. Garg, Maja Herco, Prem S. Shekhawat and Yan-Hua Chen

    Citation: BMC Pediatrics 2018 18:372

    Content type: Research article

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  8. Delayed diagnosis of critical congenital heart disease (CCHD) carries a serious risk of mortality, morbidity, and handicap. As echocardiography is commonly used to diagnose congenital heart disease (CHD), echo...

    Authors: Miyuki Kondo, Akira Ohishi, Toru Baba, Tomoka Fujita and Shigeo Iijima

    Citation: BMC Pediatrics 2018 18:359

    Content type: Research article

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  9. Neonatal sepsis is one of the most important causes of mortality in developing countries and yet the most preventable. In developing countries clinical algorithms are used to diagnose clinical neonatal sepsis ...

    Authors: Violet Okaba Kayom, Jamiir Mugalu, Abel Kakuru, Sarah Kiguli and Charles Karamagi

    Citation: BMC Pediatrics 2018 18:355

    Content type: Research article

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  10. Despite worldwide efforts to reduce neonatal mortality, 44% of under-five deaths occur in the first 28 days of life. The primary causes of neonatal death are preventable or treatable. This study describes the ...

    Authors: Merab Nyishime, Ryan Borg, Willy Ingabire, Bethany Hedt-Gauthier, Evrard Nahimana, Neil Gupta, Anne Hansen, Michelle Labrecque, Fulgence Nkikabahizi, Christine Mutaganzwa, Francois Biziyaremye, Claudine Mukayiranga, Francine Mwamini and Hema Magge

    Citation: BMC Pediatrics 2018 18:353

    Content type: Research article

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  12. Congenital bilateral vocal cord paralysis is a rare occurrence. Approximately half the cases are associated with a major comorbidity, usually neurological, neuromuscular or malformative.

    Authors: Camille Brotelande, Nicolas Leboucq, Mohamed Akkari, Thomas Roujeau, Massimo Di Maio, Christophe Milési, Michel Mondain, Charles Raybaud and Gilles Cambonie

    Citation: BMC Pediatrics 2018 18:351

    Content type: Case report

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  13. Preterm infants are especially vulnerable to pain. The intensive treatment often necessary for their survival unfortunately includes many painful interventions and procedures. Untreated pain can lead to both s...

    Authors: Emma Olsson, Agneta Anderzén-Carlsson, Sigríður María Atladóttir, Anna Axelin, Marsha Campbell-Yeo, Mats Eriksson, Guðrún Kristjánsdóttir, Emilia Peltonen, Bonnie Stevens, Bente Vederhus and Randi Dovland Andersen

    Citation: BMC Pediatrics 2018 18:349

    Content type: Research article

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  15. Neonatal severe primary hyperparathyroidism (NSHPT) is a rare autosomal recessive disorder of calcium homeostasis, characterized by striking hyperparathyroidism, marked hypercalcemia and hyperparathyroid bone ...

    Authors: Manuela Capozza, Iolanda Chinellato, Vito Guarnieri, Natascia Di lorgi, Maria Accadia, Cristina Traggiai, Girolamo Mattioli, Antonio Di Mauro and Nicola Laforgia

    Citation: BMC Pediatrics 2018 18:340

    Content type: Case report

    Published on:

    The Correction to this article has been published in BMC Pediatrics 2019 19:463

  16. There is evidence that delivery room resuscitation of very preterm infants often deviates from internationally recommended guidelines. There were no published data in Spain regarding the quality of neonatal re...

    Authors: Silvia Maya-Enero, Francesc Botet-Mussons, Josep Figueras-Aloy, Montserrat Izquierdo-Renau, Marta Thió and Martin Iriondo-Sanz

    Citation: BMC Pediatrics 2018 18:319

    Content type: Research article

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  17. Childhood mortality remains high in resource-limited third world countries. Most childhood deaths in hospital often occur within the first 24 h of admission. Many of these deaths are from preventable causes. T...

    Authors: Gemechu Jofiro, Kemal Jemal, Lemlem Beza and Tigist Bacha Heye

    Citation: BMC Pediatrics 2018 18:316

    Content type: Research article

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  18. This study compares the minimally invasive Bilistick and a noninvasive method with standard Total Serum Bilirubin (TSB) measurement in preterm newborns receiving phototherapy. We assess the agreement of Transc...

    Authors: Rinawati Rohsiswatmo, Hanifah Oswari, Radhian Amandito, Hikari Ambara Sjakti, Endang Windiastuti, Rosalina Dewi Roeslani and Indrayady Barchia

    Citation: BMC Pediatrics 2018 18:315

    Content type: Research article

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  19. Stimulation is the most common intervention during neonatal resuscitation at birth, but scarce information is available on the actual methods, timing and efficacy of this basic step. To evaluate the occurrence...

    Authors: Andrea Pietravalle, Francesco Cavallin, Anna Opocher, Stefania Madella, Maria Elena Cavicchiolo, Damiano Pizzol, Giovanni Putoto and Daniele Trevisanuto

    Citation: BMC Pediatrics 2018 18:306

    Content type: Research article

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  20. Neonatal hypoxic-ischemic encephalopathy (HIE) commonly leads to neurodevelopmental impairment, raising the need for prognostic tools which may guide future therapies in time. Prognostic value of proton MR spe...

    Authors: Hajnalka Barta, Agnes Jermendy, Marton Kolossvary, Lajos R. Kozak, Andrea Lakatos, Unoke Meder, Miklos Szabo and Gabor Rudas

    Citation: BMC Pediatrics 2018 18:302

    Content type: Research article

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  21. Congenital brain lesions expose infants to be at high-risk for being affected by neurodevelopmental disorders such as cerebral palsy (CP). Early interventions programs can significantly impact and improve thei...

    Authors: Giuseppina Sgandurra, Elena Beani, Matteo Giampietri, Riccardo Rizzi and Giovanni Cioni

    Citation: BMC Pediatrics 2018 18:295

    Content type: Study protocol

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  22. Although persistent pulmonary hypertension of the newborn (PPHN) and infantile hypertrophic pyloric stenosis (HPS) are both well-known diseases that occur in early infancy, PPHN complicated by HPS is rare. As ...

    Authors: Shigeo Iijima, Daizo Ueno, Toru Baba and Akira Ohishi

    Citation: BMC Pediatrics 2018 18:290

    Content type: Case report

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  23. Intraventricular hemorrhage (IVH) is a frequent complication in extreme and very preterm births. Despite a high risk of death and impaired neurodevelopment, the precise prognosis of infants with IVH remains un...

    Authors: Vianney Gilard, Alexandra Chadie, François-Xavier Ferracci, Marie Brasseur-Daudruy, François Proust, Stéphane Marret and Sophie Curey

    Citation: BMC Pediatrics 2018 18:288

    Content type: Research article

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  24. The supply of breast milk to preterm infants tends to occur at a lower rate than that recorded among term infants. We aimed to investigate the facilitators of and barriers to breastfeeding during hospital stay...

    Authors: Maria Lorella Gianni, Elena Nicoletta Bezze, Patrizio Sannino, Michela Baro, Paola Roggero, Salvatore Muscolo, Laura Plevani and Fabio Mosca

    Citation: BMC Pediatrics 2018 18:283

    Content type: Research article

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  25. Survival of preterm neonates has steadily improved over the past five decades, due to changes in the neonatal intensive care. However, in Saudi Arabia, there are no written guidelines on the definition of the ...

    Authors: Mostafa A. Abolfotouh, Saif Al Saif, Waleed A. Altwaijri and Mohammed A. Al Rowaily

    Citation: BMC Pediatrics 2018 18:280

    Content type: Research article

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  26. Sick newborns in neonatal units who are unable to breastfeed are fed expressed breast milk. In Sri Lanka, most mothers stay in hospital throughout baby’s stay to provide this milk freshly. In other countries m...

    Authors: Ranmali Rodrigo, Lisa H. Amir and Della A. Forster

    Citation: BMC Pediatrics 2018 18:271

    Content type: Research article

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  27. Necrotizing enterocolitis (NEC) is a leading cause of neonatal morbidity and mortality in premature infants. To date, no effective biomarkers exist to predict which premature infants will develop NEC, limiting...

    Authors: Terri Marin, Ravi M. Patel, John D. Roback, Sean R. Stowell, Ying Guo, Kirk Easley, Megan Warnock, Jane Skvarich and Cassandra D. Josephson

    Citation: BMC Pediatrics 2018 18:270

    Content type: Study protocol

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  28. Preterm infants are high risk for delayed neurodevelopment. The main goal is to develop a program of early intervention for very preterm infants that allows families to apply it continuously at home, and quant...

    Authors: Rita C. Silveira, Eliane Wagner Mendes, Rubia Nascimento Fuentefria, Nadia Cristina Valentini and Renato S. Procianoy

    Citation: BMC Pediatrics 2018 18:268

    Content type: Study protocol

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  29. Seven years of age is a milestone for learning basic knowledge that is strongly related to attention abilities such as Alerting, Orienting, and Inhibition function, allowing for appropriate adaptation to prima...

    Authors: Hadrien Ceyte, Joëlle Rosenbaum, Isabelle Hamon, Maëlle Wirth, Sébastien Caudron and Jean-Michel Hascoët

    Citation: BMC Pediatrics 2018 18:264

    Content type: Study protocol

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  30. Neonatal hypothermia is a worldwide problem and an important contributing factor for Neonatal morbidity and mortality especially in developing countries. High prevalence of hypothermia has been reported from c...

    Authors: Birhanu Wondimeneh Demissie, Balcha Berhanu Abera, Tesfaye Yitna Chichiabellu and Feleke Hailemichael Astawesegn

    Citation: BMC Pediatrics 2018 18:263

    Content type: Research article

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  31. Much controversy exists about the optimal management of a patent ductus arteriosus (PDA) in preterm infants, especially in those born at a gestational age (GA) less than 28 weeks. No causal relationship has be...

    Authors: Tim Hundscheid, Wes Onland, Bart van Overmeire, Peter Dijk, Anton H. L. C. van Kaam, Koen P. Dijkman, Elisabeth M. W. Kooi, Eduardo Villamor, André A. Kroon, Remco Visser, Daniel C. Vijlbrief, Susanne M. de Tollenaer, Filip Cools, David van Laere, Anne-Britt Johansson, Catheline Hocq…

    Citation: BMC Pediatrics 2018 18:262

    Content type: Study protocol

    Published on:

  32. The death of a child before or shortly after birth is frequently preceded by an end-of-life decision (ELD). Population-based studies of incidence and characteristics of ELDs in neonates and infants are rare, a...

    Authors: Laure Dombrecht, Kim Beernaert, Ellen Roets, Kenneth Chambaere, Filip Cools, Linde Goossens, Gunnar Naulaers, Luc De Catte, Joachim Cohen and Luc Deliens

    Citation: BMC Pediatrics 2018 18:260

    Content type: Study protocol

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  33. Hypoxic-ischemic encephalopathy (HIE) is a rare neonatal condition affecting about 1‰ births. Despite a significant improvement in the management of this condition in the last ten years, HIE remains associated...

    Authors: Thierry Debillon, Nathalie Bednarek and Anne Ego

    Citation: BMC Pediatrics 2018 18:255

    Content type: Study protocol

    Published on:

  34. Sepsis is a leading cause of morbidity and mortality among newborns. C-reactive protein (CRP) and procalcitonin (PCT) have some limitations in the diagnosis of preterm neonatal sepsis. In this study, the cut-o...

    Authors: C. Aydemir, H. Aydemir, F. Kokturk, C. Kulah and A. G. Mungan

    Citation: BMC Pediatrics 2018 18:253

    Content type: Research article

    Published on:

  36. Unlicensed and off label drug use is an issue recognized worldwide in pediatric pharmacotherapy. The study was designed to assess the prevalence and predictors of unlicensed and off label drug use in neonatal ...

    Authors: Muhammad Aamir, Jamshaid Ali Khan, Faisal Shakeel, Rabeea Shareef and Nazia Shah

    Citation: BMC Pediatrics 2018 18:242

    Content type: Research article

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  37. Early discharge of very low birth weight infant (VLBW) in low resource settings is inevitable but to minimize mortality of these infants after discharge we need to identify the death attributes.

    Authors: Yaser Abdallah, Flavia Namiiro, Jolly Nankunda, Jamiru Mugalu and Yvonne Vaucher

    Citation: BMC Pediatrics 2018 18:239

    Content type: Research article

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  38. Delayed cord clamping is the standard of care in infants not requiring resuscitation; however effects of cord clamping strategies have not been evaluated systematically in small for gestational age (SGA) infan...

    Authors: Abhishek Chopra, Anup Thakur, Pankaj Garg, Neelam Kler and Kanwal Gujral

    Citation: BMC Pediatrics 2018 18:234

    Content type: Research article

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  39. Measurement of transcutaneous bilirubin (TcB) is a quick, reliable and painless method to guide management of hyperbilirubinemia. Studies in term and late preterm infants have found that TcB measurements from ...

    Authors: Vidit Bhargava, Daniel Tawfik, Bruce Niebuhr and Sunil K. Jain

    Citation: BMC Pediatrics 2018 18:227

    Content type: Research article

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  40. Various intervention programs exist for parents of preterm babies and some systematic reviews (SRs) have synthesised the evidence of their effectiveness. These reviews are, however, limited to specific interve...

    Authors: Shuby Puthussery, Muhammad Chutiyami, Pei-Ching Tseng, Lesley Kilby and Jogesh Kapadia

    Citation: BMC Pediatrics 2018 18:223

    Content type: Research article

    Published on:

  41. Babies born at moderate-late preterm gestations account for > 80% of all preterm births. Although survival is excellent, these babies are at increased risk of adverse neurodevelopmental outcomes. They also are...

    Authors: Frank H. Bloomfield, Jane E. Harding, Michael P. Meyer, Jane M. Alsweiler, Yannan Jiang, Clare R. Wall and Tanith Alexander

    Citation: BMC Pediatrics 2018 18:220

    Content type: Study protocol

    Published on:

  42. Generalized Arterial Calcification of Infancy (GACI) is a heritable ectopic mineralization disorder resulting in diffuse arterial calcifications and/or stenosis, mostly caused by mutations in the ENPP1 gene. Here...

    Authors: Iole Brunod, Barthélémy Tosello, Sophie Hassid, Catherine Gire, Laurent Thomachot and Michel Panuel

    Citation: BMC Pediatrics 2018 18:217

    Content type: Case report

    Published on:

  43. Very preterm birth (24 to < 32 week’s gestation) is a major public health issue due to its prevalence, the clinical and ethical questions it raises and the associated costs. It raises two major clinical and et...

    Authors: Isabelle Aujoulat, Séverine Henrard, Anne Charon, Anne-Britt Johansson, Jean-Paul Langhendries, Anne Mostaert, Danièle Vermeylen and Gaston Verellen

    Citation: BMC Pediatrics 2018 18:206

    Content type: Research article

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  45. Neonatal hyperbilirubinaemia is one of the commonest causes of hospital visit in the neonatal period. When severe, it is a leading cause of irreversible neurological and musculoskeletal disability. Prompt reco...

    Authors: Chidiebere D. I. Osuorah, Uchenna Ekwochi and Isaac N. Asinobi

    Citation: BMC Pediatrics 2018 18:202

    Content type: Research article

    Published on:

  47. Indirect neonatal hyperbilirubinemia (INH) is a common neonatal disorder worldwide which can remain benign if prompt management is available. However there is a higher morbidity and mortality risk in settings ...

    Authors: L. Thielemans, M. Trip-Hoving, J. Landier, C. Turner, T. J. Prins, E. M. N. Wouda, B. Hanboonkunupakarn, C. Po, C. Beau, M. Mu, T. Hannay, F. Nosten, B. Van Overmeire, R. McGready and V. I. Carrara

    Citation: BMC Pediatrics 2018 18:190

    Content type: Research article

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  48. Considering the significant prevalence of Neonatal Indirect Hyperbilirubinemia (NIH) and its irreversible neurological complications, identifying the factors involved in the prevalence of neonatal jaundice is ...

    Authors: Shahrokh Mehrpisheh, Azadeh Memarian, Abolfazl Mahyar and Negin Sadat Valiahdi

    Citation: BMC Pediatrics 2018 18:178

    Content type: Research article

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  49. To investigate the trends in the incidence and associated factors of late-onset sepsis (LOS) associated with improved survival in extremely preterm infants.

    Authors: Jin Kyu Kim, Yun Sil Chang, Sein Sung, So Yoon Ahn and Won Soon Park

    Citation: BMC Pediatrics 2018 18:172

    Content type: Research article

    Published on:

  50. About three – quarters of all neonatal deaths occur during the first week of life, with over half of these occurring within the first 24 h after birth. The first minutes after birth are critical to reducing ne...

    Authors: Duncan N. Shikuku, Benson Milimo, Elizabeth Ayebare, Peter Gisore and Gorrette Nalwadda

    Citation: BMC Pediatrics 2018 18:167

    Content type: Research article

    Published on:

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