This section considers studies regarding all aspects of neonatal health, disease, care, and outcomes.

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  1. Research article

    Umbilical cord bilirubin as a predictor of neonatal jaundice: a retrospective cohort study

    Hyperbilirubinaemia is a major cause of neonatal morbidity. Early identification of those infants most at risk might allow the development of targeted primary preventative therapy and follow-up. The objective ...

    Kelsey D. J. Jones, S E. Grossman, Dharshini Kumaranayakam, Arati Rao, Greg Fegan and Narendra Aladangady

    BMC Pediatrics 2017 17:186

    Published on: 20 September 2017

  2. Study protocol

    Individual contextual factors in the validation of the Bernese pain scale for neonates: protocol for a prospective observational study

    The Bernese Pain Scale for Neonates (BPSN) is a multidimensional pain assessment tool that is already widely used in clinical settings in the German speaking areas of Europe. Recent findings indicate that pain...

    Eva Cignacco, Karin Schenk, Bonnie Stevens, Liliane Stoffel, Dirk Bassler, Sven Schulzke and Mathias Nelle

    BMC Pediatrics 2017 17:171

    Published on: 19 July 2017

  3. Study protocol

    Prediction of Extubation readiness in extremely preterm infants by the automated analysis of cardiorespiratory behavior: study protocol

    Extremely preterm infants (≤ 28 weeks gestation) commonly require endotracheal intubation and mechanical ventilation (MV) to maintain adequate oxygenation and gas exchange. Given that MV is independently assoc...

    Wissam Shalish, Lara J. Kanbar, Smita Rao, Carlos A. Robles-Rubio, Lajos Kovacs, Sanjay Chawla, Martin Keszler, Doina Precup, Karen Brown, Robert E. Kearney and Guilherme M. Sant’Anna

    BMC Pediatrics 2017 17:167

    Published on: 17 July 2017

  4. Study protocol

    Study protocol: safety and efficacy of propranolol 0.2% eye drops in newborns with a precocious stage of retinopathy of prematurity (DROP-ROP-0.2%): a multicenter, open-label, single arm, phase II trial

    Retinopathy of prematurity (ROP) still represents one of the leading causes of visual impairment in childhood. Systemic propranolol has proven to be effective in reducing ROP progression in preterm newborns, a...

    Luca Filippi, Giacomo Cavallaro, Elettra Berti, Letizia Padrini, Gabriella Araimo, Giulia Regiroli, Valentina Bozzetti, Chiara De Angelis, Paolo Tagliabue, Barbara Tomasini, Giuseppe Buonocore, Massimo Agosti, Angela Bossi, Gaetano Chirico, Salvatore Aversa, Roberta Pasqualetti…

    BMC Pediatrics 2017 17:165

    Published on: 14 July 2017

  5. Research article

    Comparing very low birth weight versus very low gestation cohort methods for outcome analysis of high risk preterm infants

    Compared to very low gestational age (<32 weeks, VLGA) cohorts, very low birth weight (<1500 g; VLBW) cohorts are more prone to selection bias toward small-for-gestational age (SGA) infants, which may impact u...

    Louise IM Koller-Smith, Prakesh S. Shah, Xiang Y. Ye, Gunnar Sjörs, Yueping A. Wang, Sharon S. W. Chow, Brian A. Darlow, Shoo K. Lee, Stellan Håkanson and Kei Lui

    BMC Pediatrics 2017 17:166

    Published on: 14 July 2017

  6. Research article

    Early characteristics of infants with pulmonary hypertension in a referral neonatal intensive care unit

    Approximately 8–23% of premature infants develop pulmonary hypertension (PH), and this diagnosis confers a higher possibility of mortality. As a result, professional societies recommend PH screening in prematu...

    Shilpa Vyas-Read, Usama Kanaan, Prabhu Shankar, Jane Stremming, Curtis Travers, David P. Carlton and Anne Fitzpatrick

    BMC Pediatrics 2017 17:163

    Published on: 11 July 2017

  7. Research article

    Transition to parenthood in the neonatal care unit: a qualitative study and conceptual model designed to illuminate parent and professional views of the impact of webcam technology

    Complications during pregnancy, childbirth and/or the postnatal period may result in the admission of a baby to a neonatal unit (NNU). While the survival and long-term prospects of high-risk infants are enhanc...

    Susan Kerr, Caroline King, Rhona Hogg, Kerri McPherson, Janet Hanley, Maggie Brierton and Sean Ainsworth

    BMC Pediatrics 2017 17:158

    Published on: 11 July 2017

  8. Research article

    Screening for glucose-6-phosphate dehydrogenase deficiency in neonates: a comparison between cord and peripheral blood samples

    The use of cord blood in the neonatal screening for glucose-6-phosphate dehydrogenase (G6PD) deficiency is being done with increasing frequency but has yet to be adequately evaluated against the use of periphe...

    Saif AlSaif, Ma. Bella Ponferrada, Khalid AlKhairy, Khalil AlTawil, Adel Sallam, Ibrahim Ahmed, Mohammed Khawaji, Khalid AlHathlol, Beverly Baylon, Ahmed AlSuhaibani and Mohammed AlBalwi

    BMC Pediatrics 2017 17:159

    Published on: 11 July 2017

  9. Research article

    Knowledge and practice of immediate newborn care among health care providers in eastern zone public health facilities, Tigray, Ethiopia, 2016

    According to WHO (2013) report the number of under five-year mortality in Ethiopia was 195,504, out of this 84,437 was from neonatal death and this mortality is related to immediate obstetric and newborn care ...

    Abadi Kidanemariam Berhe, Fitiwi Tinsae and Gebremedhin Gebreegziabher

    BMC Pediatrics 2017 17:157

    Published on: 11 July 2017

  10. Research article

    Prevalence, severity and early outcomes of hypoxic ischemic encephalopathy among newborns at a tertiary hospital, in northern Tanzania

    Hypoxic Ischemic Encephalopathy (HIE) remains a problem of great concern worldwide especially in developing countries. The occurrence of a neurological syndrome can be an indicator of insult to the brain. We a...

    Irene N. Simiyu, Deborah N. Mchaile, Kahindo Katsongeri, Rune N. Philemon and Sia E. Msuya

    BMC Pediatrics 2017 17:131

    Published on: 25 May 2017

  11. Research article

    Neonatal respiratory morbidity following exposure to chorioamnionitis

    There are conflicting results in the literature on the impact of chorioamnionitis on neonatal respiratory morbidities. However, most studies are based on small clinical samples and fail to account for the comp...

    Amy Metcalfe, Sarka Lisonkova, Yasser Sabr, Amelie Stritzke and KS Joseph

    BMC Pediatrics 2017 17:128

    Published on: 17 May 2017

  12. Research article

    Foot length, chest and head circumference measurements in detection of Low birth weight neonates in Mekelle, Ethiopia: a hospital based cross sectional study

    Low birth weight (Birth weight < 2500 g) is a leading cause of prenatal and neonatal deaths. The early identification of Low birth weight (LBW) neonates is essential for any comprehensive initiative to improve...

    Marta Yemane Hadush, Amanuel Hadgu Berhe and Araya Abrha Medhanyie

    BMC Pediatrics 2017 17:111

    Published on: 21 April 2017

  13. Research article

    Evaluation of Helping Babies Breathe Quality Improvement Cycle (HBB-QIC) on retention of neonatal resuscitation skills six months after training in Nepal

    Each year 700,000 infants die due to intrapartum-related complications. Implementation of Helping Babies Breathe (HBB)-a simplified neonatal resuscitation protocol in low-resource clinical settings has shown t...

    Ashish KC, Johan Wrammert, Viktoria Nelin, Robert B. Clark, Uwe Ewald, Stefan Peterson and Mats Målqvist

    BMC Pediatrics 2017 17:103

    Published on: 11 April 2017

  14. Research article

    Prevention of neonatal late-onset sepsis: a randomised controlled trial

    Late-onset sepsis (LOS), defined as sepsis occurring after 48 h of age causes substantial mortality and morbidity in very low birth weight infants. Risk factors for LOS include immaturity, intravascular cathet...

    Gary Alcock, Helen G. Liley, Lucy Cooke and Peter H. Gray

    BMC Pediatrics 2017 17:98

    Published on: 4 April 2017

  15. Research article

    Melatonin alleviates brain and peripheral tissue edema in a neonatal rat model of hypoxic-ischemic brain damage: the involvement of edema related proteins

    Previous studies have indicated edema may be involved in the pathophysiology following hypoxic-ischemic encephalopathy (HIE), and melatonin may exhibit neuro-protection against brain insults. However, little i...

    Li-Xiao Xu, Yuan Lv, Yan-Hong Li, Xin Ding, Ying Wang, Xing Han, Ming-Hua Liu, Bin Sun and Xing Feng

    BMC Pediatrics 2017 17:90

    Published on: 28 March 2017

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