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Neonatology

Section edited by Elizabeth Asztalos

This section considers studies regarding all aspects of neonatal health, disease, care, and outcomes.

Page 1 of 10

  3. The early life period represents the first step in establishing a beneficial microbial ecosystem, which in turn affects both short and longer-term health. Changes during pregnancy influence the neonatal microb...

    Authors: Sarah Phillips, Rachel Watt, Thomas Atkinson, George M Savva, Antonietta Hayhoe and Lindsay J Hall

    Citation: BMC Pediatrics 2021 21:357

    Content type: Study protocol

    Published on:

  5. The most common cause of respiratory failure in premature infants is respiratory distress syndrome. Historically, respiratory distress syndrome has been treated by intratracheal surfactant injection followed b...

    Authors: Arash Malakian, Mohammad Reza Aramesh, Mina Agahin and Masoud Dehdashtian

    Citation: BMC Pediatrics 2021 21:301

    Content type: Research article

    Published on:

  6. The prevalence of diabetes mellitus (DM) during pregnancy and childhood obesity is increasing worldwide. Factors affecting the growth of children with overweight whose mothers had DM are complicated and inconc...

    Authors: Yuan-Der Huang, Yun-Ru Luo, Meng-Chih Lee and Chih-Jung Yeh

    Citation: BMC Pediatrics 2021 21:298

    Content type: Research article

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  8. Neonatal hypoxic-ischemic encephalopathy (HIE) affects as many as 100,000 infants each year in China. Therapeutic hypothermia reduces HIE related mortality and long-term neurodevelopmental disabilities. Nation...

    Authors: Zheng Wang, Peng Zhang, Wenhao Zhou, Shiwen Xia, Wei Zhou, Xiaoyu Zhou, Xiuyong Cheng, Yuan Shi, Zhenlang Lin, Dongli Song and Guoqiang Cheng

    Citation: BMC Pediatrics 2021 21:261

    Content type: Research article

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  9. Bronchopulmonary dysplasia (BPD) infants present an increased incidence of metabolic bone disease (MBD), but it is unknown which factors contribute to this. The aim of this study was to determine the risk fact...

    Authors: Wenwen Chen, Zhenhai Zhang, Shuzhen Dai and Liping Xu

    Citation: BMC Pediatrics 2021 21:235

    Content type: Research article

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  10. As preterm infants’ neurodevelopment is shaped by NICU-related factors during their hospitalization, it is essential to evaluate which interventions are more beneficial for their neurodevelopment at this speci...

    Authors: Marilyn Aita, Gwenaëlle De Clifford Faugère, Andréane Lavallée, Nancy Feeley, Robyn Stremler, Émilie Rioux and Marie-Hélène Proulx

    Citation: BMC Pediatrics 2021 21:210

    Content type: Research article

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  11. Human milk is recommended for very preterm infants, but its variable macronutrient content may contribute to undernutrition during a critical period in development. We hypothesize that individually targeted hu...

    Authors: Mandy B. Belfort, Lianne J. Woodward, Sara Cherkerzian, Hunter Pepin, Deirdre Ellard, Tina Steele, Christoph Fusch, P. Ellen Grant and Terrie E. Inder

    Citation: BMC Pediatrics 2021 21:167

    Content type: Study protocol

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  12. The implementation of early intervention (EI) in medical settings is time-consuming and resource-intensive, which limits its extensive use. In 2018, the Chinese Eugenics Association developed a home-based, pos...

    Authors: Juan Fan, Jianhui Wang, Xianhong Zhang, Ruiyun He, Shasha He, Mei Yang, Yujie Shen, Xiaojun Tao, Mei Zhou, Xiong Gao and Lijun Hu

    Citation: BMC Pediatrics 2021 21:162

    Content type: Research article

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  13. Systemic juvenile xanthogranuloma is a very rare disease typically presents as skin lesions with yellow papules or nodules and is sometimes fatal. We report a case of congenital neonatal systemic juvenile xant...

    Authors: Yohji Uehara, Yuka Sano Wada, Yuka Iwasaki, Kota Yoneda, Yasuhisa Ikuta, Shoichiro Amari, Hidehiko Maruyama, Keiko Tsukamoto, Tetsuya Isayama, Kenichi Sakamoto, Yoko Shioda, Osamu Miyazaki, Rie Irie, Takako Yoshioka, Naoko Mochimaru, Kazue Yoshida…

    Citation: BMC Pediatrics 2021 21:161

    Content type: Case report

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  14. Prematurity escalates the crisis of the infants a susceptible group of the society. Multiple delivery further intensifies the susceptibility of both family and health system. A comprehensive care is, thus, nec...

    Authors: Tahereh Changiz and Mahboobeh Namnabati

    Citation: BMC Pediatrics 2021 21:150

    Content type: Research article

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  15. Multi-sensory behavioral interventions for preterm infants have the potential to accelerate feeding, growth, and optimize developmental trajectories and increase parents’ interactive engagement with their infa...

    Authors: Rosemary White-Traut, Debra Brandon, Karen Kavanaugh, Karen Gralton, Wei Pan, Evan R. Myers, Bree Andrews, Michael Msall and Kathleen F. Norr

    Citation: BMC Pediatrics 2021 21:142

    Content type: Study protocol

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  17. The gut microbiota and the brain are connected through different mechanisms. Bacterial colonisation of the gut plays a substantial role in normal brain development, providing opportunities for nutritional neur...

    Authors: Lisa M. Hortensius, Edith H. van den Hooven, Jeroen Dudink, Maria Luisa Tataranno, Ruurd M. van Elburg and Manon J. N. L. Benders

    Citation: BMC Pediatrics 2021 21:132

    Content type: Study protocol

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  18. To evaluate the long-term functional and structural pulmonary development in children with repaired congenital diaphragmatic hernia (CDH) and to identify the associated perinatal-neonatal risk factors.

    Authors: June-Young Koh, Euiseok Jung, Hyun Woo Goo, Seong-Chul Kim, Dae Yeon Kim, Jung-Man Namgoong, Byong Sop Lee, Ki-Soo Kim and Ellen Ai-Rhan Kim

    Citation: BMC Pediatrics 2021 21:120

    Content type: Research article

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  19. The question of whether to treat patent ductus arteriosus (PDA) early or wait until symptoms appear remains high on the research agenda for neonatal medicine. Around 7000 extremely preterm babies under 29 week...

    Authors: Samir Gupta, Edmund Juszczak, Pollyanna Hardy, Nimish Subhedar, Jonathan Wyllie, Wilf Kelsall, Sunil Sinha, Sam Johnson, Tracy Roberts, Elisabeth Hutchison, Justine Pepperell, Louise Linsell, Jennifer L. Bell, Kayleigh Stanbury, Marketa Laube, Clare Edwards…

    Citation: BMC Pediatrics 2021 21:100

    Content type: Study protocol

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    The Correction to this article has been published in BMC Pediatrics 2021 21:326

    The Update to this article has been published in Trials 2021 22:368

  20. In neonatal intensive care unit (NICU) patients with intubation status, fluoroscopic evaluation for the bowel is limited. This study was to evaluate the utility of bedside upper gastrointestinal (UGI) series w...

    Authors: Choeum Kang, Haesung Yoon, Hyun Joo Shin, Ho Sun Eun, Kook In Park and Mi-Jung Lee

    Citation: BMC Pediatrics 2021 21:91

    Content type: Research article

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  21. Neonatal mortality contributes to nearly half of child deaths globally and the majority of these deaths are preventable. Poor quality of care is a major driver of neonatal mortality in low- and middle-income c...

    Authors: David Tuyisenge, Samuel Byiringiro, M. Louise Manirakiza, Robert G. Mutsinzi, Alphonse Nshimyiryo, Merab Nyishime, Lisa R. Hirschhorn, Francois Biziyaremye, Joseph Gitera, Kathryn Beck and Catherine M. Kirk

    Citation: BMC Pediatrics 2021 21:89

    Content type: Research article

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  23. Nowadays, it is generally assumed that non-pharmacologic pain relief in preterm infants is an important measure to consider. Research findings suggest that familiar odors have soothing effects for neonates. Th...

    Authors: Zahra Akbarian Rad, Parvin Aziznejadroshan, Adeleh Saebi Amiri, Hemmat Gholinia Ahangar and Zahra Valizadehchari

    Citation: BMC Pediatrics 2021 21:61

    Content type: Research article

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  24. It is shown that meeting the increased nutritional demand of preterm infants from birth is not only important for survival but essentially contributes to the infants` overall development and long-term health.

    Authors: Edda Hofstätter, Verena Köttstorfer, Patricia Stroicz, Sebastian Schütz, Lorenz Auer-Hackenberg, Johannes Brandner and Martin Wald

    Citation: BMC Pediatrics 2021 21:56

    Content type: Research article

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  25. Population-based studies analyzing neonatal deaths in middle-income countries may contribute to design interventions to achieve the Sustainable Development Goals, established by United Nations. This study goal...

    Authors: Ruth Guinsburg, Adriana Sanudo, Carlos Roberto V Kiffer, Ana Sílvia S Marinonio, Daniela T Costa-Nobre, Kelsy N Areco, Mandira D Kawakami, Milton H Miyoshi, Paulo Bandiera-Paiva, Rita de Cássia X Balda, Tulio Konstantyner, Liliam CC Morais, Rosa MV Freitas, Mônica LP Teixeira, Bernadette Waldvogel and Maria Fernanda B Almeida

    Citation: BMC Pediatrics 2021 21:54

    Content type: Research article

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  26. Peripheral blood eosinophilia is identified in numerous medical conditions associated with allergic, infectious, and inflammatory processes mostly as reactive eosinophilia with or without tissue eosinophilia. ...

    Authors: Cheong-Jun Moon, Tae Hee Kwon and Hyun-Seung Lee

    Citation: BMC Pediatrics 2021 21:49

    Content type: Case report

    Published on:

  27. Surviving children born at 23 gestational weeks are a growing population. As many of these children face developmental challenges during childhood and adolescence, more knowledge is needed about the everyday l...

    Authors: Anniina Väliaho, Liisa Lehtonen, Anna Axelin and Riikka Korja

    Citation: BMC Pediatrics 2021 21:48

    Content type: Research article

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  29. Neonatal jaundice is one of the most common problems in neonates. Effective treatment of jaundice requires therapeutic intervention with high quality phototherapy. Over recent years, several studies reported f...

    Authors: Helvi N. Joel, Deborah N. Mchaile, Rune N. Philemon, Ronald M. Mbwasi and Levina Msuya

    Citation: BMC Pediatrics 2021 21:32

    Content type: Research article

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  30. Parent-infant closeness during hospital care of newborns has many benefits for both infants and parents. We developed an educational intervention for neonatal staff, Close Collaboration with Parents, to increa...

    Authors: Felix B. He, Anna Axelin, Sari Ahlqvist-Björkroth, Simo Raiskila, Eliisa Löyttyniemi and Liisa Lehtonen

    Citation: BMC Pediatrics 2021 21:28

    Content type: Research article

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  31. Current nutritional management of infants born very preterm results in significant deficiency of the essential fatty acids (FAs) arachidonic acid (ARA) and docosahexaenoic acid (DHA). The impact of this defici...

    Authors: Kristina Wendel, Helle Cecilie Viekilde Pfeiffer, Drude Merete Fugelseth, Eirik Nestaas, Magnus Domellöf, Bjorn Steen Skålhegg, Katja Benedikte Presto Elgstøen, Helge Rootwelt, Rolf Dagfinn Pettersen, Are Hugo Pripp, Tom Stiris and Sissel J. Moltu

    Citation: BMC Pediatrics 2021 21:19

    Content type: Study protocol

    Published on:

  32. We propose a modified lung ultrasound (LUS) score in neonates with respiratory distress syndrome (RDS), which includes posterior instead of lateral lung fields, and a 5-grade rating scale instead of a 4-grade ...

    Authors: Piotr Szymański, Piotr Kruczek, Roman Hożejowski and Piotr Wais

    Citation: BMC Pediatrics 2021 21:17

    Content type: Research article

    Published on:

  33. Previous studies have indicated that the majority of cases with “failed” results related to transient evoked otoacoustic emissions (OAE) test have the normal hearing. The present study aimed to assess the poss...

    Authors: Mahbod Kaveh, Seyedeh Nastaran Mirjalali, Mamak Shariat and Mohammad Reza Zarkesh

    Citation: BMC Pediatrics 2021 21:15

    Content type: Research article

    Published on:

  34. Globally, 15 million neonates are born prematurely every year, over half in low income countries (LICs). Premature and low birth weight neonates have a higher risk of intraventricular haemorrhage (IVH). There ...

    Authors: R. MacLeod, J. N. Paulson, N. Okalany, F. Okello, L. Acom, J. Ikiror, F. M. Cowan, C. J. Tann, L. E. Dyet, C. F. Hagmann and K. Burgoine

    Citation: BMC Pediatrics 2021 21:12

    Content type: Research article

    Published on:

  35. Our objectives were (1) to describe Care Transitions Measure (CTM) scores among caregivers of preterm infants after discharge from the neonatal intensive care unit (NICU) and (2) to describe the association of...

    Authors: Amy M. Yeh, Ashley Y. Song, Douglas L. Vanderbilt, Cynthia Gong, Philippe S. Friedlich, Roberta Williams and Ashwini Lakshmanan

    Citation: BMC Pediatrics 2021 21:7

    Content type: Research article

    Published on:

  36. Pulmonary hypertension is a deadly complication of bronchopulmonary dysplasia, the most common pulmonary morbidity of prematurity. Despite these catastrophic consequences, no evidence-based therapies are avail...

    Authors: Simone Schneider, Mary Bailey, Tracy Spears, Charles R. Esther Jr, Matthew M. Laughon, Christoph P. Hornik and Wesley Jackson

    Citation: BMC Pediatrics 2020 20:559

    Content type: Study protocol

    Published on:

  37. Necrotizing enterocolitis (NEC) is a devastating disease that is relatively frequently diagnosed in term infants with congenital heart disease (CHD), compared with term infants without CHD, in whom NEC is rare...

    Authors: Martin van der Heide, Mirthe J. Mebius, Arend F. Bos, Marcus T.R. Roofthooft, Rolf M.F. Berger, Jan B.F. Hulscher and Elisabeth M.W. Kooi

    Citation: BMC Pediatrics 2020 20:553

    Content type: Research article

    Published on:

  38. To confirm the accuracy of transcutaneous bilirubin (TcB) in the neonatal intensive care unit both with and without phototherapy, and compare forehead and sternum as the TcB assessment site.

    Authors: Jaesung Jeon, Gina Lim, Ki Won Oh, Na Mi Lee, Hye Won Park and Mi Lim Chung

    Citation: BMC Pediatrics 2020 20:548

    Content type: Research article

    Published on:

  39. Parents of infants in neonatal intensive care units (NICUs) are often unintentionally marginalized in pursuit of optimal clinical care. Family Integrated Care (FICare) was developed to support families as part...

    Authors: Karen M. Benzies, Khalid Aziz, Vibhuti Shah, Peter Faris, Wanrudee Isaranuwatchai, Jeanne Scotland, Jill Larocque, Kelly J. Mrklas, Christopher Naugler, H. Thomas Stelfox, Radha Chari, Amuchou Singh Soraisham, Albert Richard Akierman, Ernest Phillipos, Harish Amin, Jeffrey S. Hoch…

    Citation: BMC Pediatrics 2020 20:535

    Content type: Research article

    Published on:

  40. Early-onset sepsis (EOS) is a potentially life-threatening complication of birth. Clinical symptoms are often unspecific and biomarkers have low predictive values for EOS. Therefore, clinical suspicion often l...

    Authors: Johan Gyllensvärd, Fredrik Ingemansson, Elisabet Hentz, Marie Studahl and Anders Elfvin

    Citation: BMC Pediatrics 2020 20:531

    Content type: Research article

    Published on:

  41. Human milk has potential protective effects against bronchopulmonary dysplasia (BPD). However, studies on the association between the dose of human milk and BPD in China are limited. This study aimed to evalua...

    Authors: Yan Xu, Zhangbin Yu, Qianqian Li, Jinjun Zhou, Xiaoguang Yin, Yuelan Ma, Yujie Yin, Shanyu Jiang, Rongping Zhu, Yue Wu, Liangrong Han, Yan Gao, Mei Xue, Yu Qiao, Lingling Zhu, Wenjuan Tu…

    Citation: BMC Pediatrics 2020 20:522

    Content type: Research article

    Published on:

  42. Intraventricular hemorrhage during the early stage is a major complication in very low birth weight infants. Elevation of venous pressure is one of the contributing factors. The internal cerebral vein receives...

    Authors: Kenichi Tanaka, Rieko Sakamoto, Hiroko Imamura, Tetsuo Naramura, Shirou Matsumoto, Masanori Iwai, Hiroshi Mitsubuchi and Kimitoshi Nakamura

    Citation: BMC Pediatrics 2020 20:517

    Content type: Case report

    Published on:

  43. Very low birth weight (VLBW) infant thermal instability upon neonatal intensive care unit admission has been associated with respiratory morbidity; however, the association between ongoing thermal instability ...

    Authors: Jane L. Ralphe, Susan G. Silva, Robin B. Dail and Debra H. Brandon

    Citation: BMC Pediatrics 2020 20:485

    Content type: Research article

    Published on:

  44. During the first period of life, critically ill as well as healthy newborn infants experience recurrent painful procedures. Parents are a valuable but often overlooked resource in procedural pain management in...

    Authors: Emma Olsson, Martina Carlsen Misic, Randi Dovland Andersen, Jenny Ericson, Mats Eriksson, Ylva Thernström Blomqvist and Alexandra Ullsten

    Citation: BMC Pediatrics 2020 20:474

    Content type: Study protocol

    Published on:

  45. No consensus has been reached on capillary blood reference intervals for platelet parameters in full-term neonates. We aimed to establish neonatal capillary blood reference intervals for platelet parameters an...

    Authors: Dongyan Cui, Yan Hou, Ling Feng, Guo Li, Chi Zhang, Yanli Huang, Jiubo Fan and Qun Hu

    Citation: BMC Pediatrics 2020 20:471

    Content type: Research article

    Published on:

  46. The high proportion of birth weight in Ethiopia is hypothesized to be due to inadequate maternal diet which is associated with poor nutrition education during pregnancy. There was no study that evaluated the e...

    Authors: Yeshalem Mulugeta Demilew, Getu Degu Alene and Tefera Belachew

    Citation: BMC Pediatrics 2020 20:466

    Content type: Research article

    Published on:

  48. In preterm infants with Respiratory Distress Syndrome (RDS), Less Invasive Surfactant Administration (LISA) has been established to reduce the need of mechanical ventilation and might improve survival rates wi...

    Authors: I. A. L. Bugter, L. C. E. Janssen, J. Dieleman, B. W. Kramer, P. Andriessen and H. J. Niemarkt

    Citation: BMC Pediatrics 2020 20:421

    Content type: Research article

    Published on:

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