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Neonatology

Section edited by Elizabeth Asztalos

This section considers studies regarding all aspects of neonatal health, disease, care, and outcomes.

Page 1 of 9

  1. Congenital diaphragmatic hernia is a deficiency of the fetal diaphragm resulting in herniation of the abdominal viscera into the thoracic cavity. The best method of respiratory management of congenital diaphra...

    Authors: Sasagu Kimura, Katsuaki Toyoshima, Tomoaki Shimokaze and Rikuo Hoshino

    Citation: BMC Pediatrics 2020 20:365

    Content type: Case report

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  2. Phenylketonuria (PKU), which is characterized by a deficiency of phenylalanine hydroxylase activity, is an autosomal recessive disorder of phenylalanine (Phe) metabolism. Newborn screening is the main populati...

    Authors: Mehdi Shokri, Parviz Karimi, Hadis Zamanifar, Fatemeh Kazemi, Gholamreza Badfar and Milad Azami

    Citation: BMC Pediatrics 2020 20:352

    Content type: Research article

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  3. Necrotising Enterocolitis (NEC) is a devastating neonatal disease. A temporal association between red cell transfusion and NEC has been recognized and there have been concerns about the effects of feeding duri...

    Authors: Tim Schindler, Kee Thai Yeo, Srinivas Bolisetty, Joanna Michalowski, Alvin Hock Kuan Tan and Kei Lui

    Citation: BMC Pediatrics 2020 20:346

    Content type: Research article

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  6. Idiopathic or transient neonatal cholestasis (TNC) represents a group of cholestatic disorders with unidentified origin and remains a diagnosis of exclusion. Dysfunction of hepatobiliary transporters mediating...

    Authors: Anna Baghdasaryan, Lisa Ofner-Ziegenfuß, Carolin Lackner, Peter Fickert, Bernhard Resch, Nicholas Mark Morris and Andrea Deutschmann

    Citation: BMC Pediatrics 2020 20:340

    Content type: Case report

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  7. Choroid plexus papillomas (CPPs) are rare, usually benign, neoplasms originating in the central nervous system. In this study, we present the first case of a giant airway-obstructing CPP in the pharynx of a ne...

    Authors: Narae Lee, Mi Hye Bae, Young Mi Han, Kyung Hee Park, Jae-Yeon Hwang, Cheong-Soo Hwang, Jin-Choon Lee and Shin Yun Byun

    Citation: BMC Pediatrics 2020 20:336

    Content type: Case report

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  8. Roughly 10% of newborns need help to complete the transition of birth. For these infants, international guidelines recommend supporting them using a 4-step procedure (A to D). Step A is an assessment time, whi...

    Authors: Claire Boithias, Laure Jule, Stephanie Le Foulgoc, Gilles Jourdain and Dan Benhamou

    Citation: BMC Pediatrics 2020 20:331

    Content type: Research article

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  9. The objective of this prospective, multicentre, observational cohort study was to evaluate the association between admission hypothermia and neonatal outcomes in very low-birth weight (VLBW) infants in multipl...

    Authors: Yong-hui Yu, Li Wang, Lei Huang, Li-ling Wang, Xiao-yang Huang, Xiu-fang Fan, Yan-jie Ding, Cheng-yuan Zhang, Qiang Liu, Ai-rong Sun, Yue-hua Zhao, Guo Yao, Cong Li, Xiu-xiang Liu, Jing-cai Wu, Zhen-ying Yang…

    Citation: BMC Pediatrics 2020 20:321

    Content type: Research article

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  10. Alveolar capillary dysplasia (ACD) is a rare cause of severe pulmonary hypertension and respiratory failure in neonates. The onset of ACD is usually preceded by a short asymptomatic period. The condition is re...

    Authors: Zuzanna Kozłowska, Zuzanna Owsiańska, Joanna P. Wroblewska, Apolonia Kałużna, Andrzej Marszałek, Yogen Singh, Bartłomiej Mroziński, Qian Liu, Justyna A. Karolak, Paweł Stankiewicz, Gail Deutsch, Marta Szymankiewicz-Bręborowicz and Tomasz Szczapa

    Citation: BMC Pediatrics 2020 20:320

    Content type: Case report

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  11. Continuous monitoring of SpO2 in the neonatal ICU is the standard of care. Changes in SpO2 exposure have been shown to markedly impact outcome, but limiting extreme episodes is an arduous task. Much more complica...

    Authors: Thomas E. Bachman, Narayan P. Iyer, Christopher J. L. Newth, Patrick A. Ross and Robinder G. Khemani

    Citation: BMC Pediatrics 2020 20:317

    Content type: Research article

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  12. Globally, possible serious bacterial infection [PSBI] is a cause for about 600,000 newborn deaths per year. To decrease the burden of this infection, a community-based management newborn PSBI when referral to ...

    Authors: Kasahun Girma Tareke, Yohannes Kebede Lemu and Garumma Tolu Feyissa

    Citation: BMC Pediatrics 2020 20:303

    Content type: Research article

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  13. Developmental dysplasia of the hip (DDH) is a common disorder in infants. The present study aimed to evaluate the efficacy and safety of the Tübingen hip flexion splints in treating DDH in infants aged 0–6 mon...

    Authors: You Zhou, Rong Li, Chuan Li, Ping Zhou, Yan Li, You-hao Ke, Fei Jiang and Xiao-peng Kang

    Citation: BMC Pediatrics 2020 20:280

    Content type: Research article

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  15. This study aimed to describe the causative organisms of neonatal late-onset sepsis (LOS) and their antimicrobial resistance in Suzhou, Southeast China over a 7-year period.

    Authors: Tao Pan, Qiujiao Zhu, Pei Li, Jun Hua and Xing Feng

    Citation: BMC Pediatrics 2020 20:261

    Content type: Research article

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  16. Necrotizing enterocolitis (NEC) is associated with significant morbidity and mortality. Serum biomarkers to aid diagnosis, such as intestinal fatty acid binding protein (IFABP) and calprotectin, are actively b...

    Authors: Darla R. Shores, Jennifer Fundora, Mitzi Go, Fauzia Shakeel, Sandra Brooks, Samuel M. Alaish, Jun Yang, Chhinder P. Sodhi, David J. Hackam and Allen Everett

    Citation: BMC Pediatrics 2020 20:250

    Content type: Research article

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  17. The guidelines of the American Academy of Pediatrics (AAP) for monitoring neonatal jaundice recommend universal postnatal screening for hyperbilirubinemia within 48 h from discharge. We observed that neonate w...

    Authors: Amit Blumovich, Laurence Mangel, Sivan Yochpaz, Dror Mandel and Ronella Marom

    Citation: BMC Pediatrics 2020 20:248

    Content type: Research article

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  18. The relation between mechanical ventilation (MV) and bronchopulmonary dysplasia (BPD) - a common disease in extremely premature newborn (PTNB) - is well stabilished, but is unknown, however, how much time unde...

    Authors: Victoria Escobar, Darllyana S. Soares, Jane Kreling, Ligia S. L. Ferrari, Josiane M. Felcar, Carlos A. M. Camillo and Vanessa S. Probst

    Citation: BMC Pediatrics 2020 20:241

    Content type: Research article

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  19. Early warning scores for neonatal mortality have not been designed for low income countries. We developed and validated a score to predict mortality upon admission to a NICU in Ethiopia.

    Authors: Rishi P. Mediratta, Ashenafi Tazebew Amare, Rasika Behl, Bradley Efron, Balasubramanian Narasimhan, Alemayehu Teklu, Abdulkadir Shehibo, Mulugeta Ayalew and Saraswati Kache

    Citation: BMC Pediatrics 2020 20:238

    Content type: Research article

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  20. Donor human milk (DHM) has been recommended for premature infants if mothers’ own milk is not available. The aim of this study was to increase the knowledge about the utilization rate and handling of DHM among...

    Authors: Daniel Klotz, Stefanie Jansen, René Glanzmann, Nadja Haiden, Hans Fuchs and Corinna Gebauer

    Citation: BMC Pediatrics 2020 20:235

    Content type: Research article

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  21. Respiratory distress syndrome (RDS) is a frequent complication of premature birth. Treating RDS by continuous positive airway pressure and less invasive surfactant administration (LISA) may reduce bronchopulmo...

    Authors: Christian A. Maiwald, Julia Dick, Matthias Marschal, Christian Gille, Axel R. Franz and Christian F. Poets

    Citation: BMC Pediatrics 2020 20:234

    Content type: Research article

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  22. Reducing neonatal mortality is an essential part of the third Sustainable Development Goal, to end preventable child deaths. Neonatal danger signs are the most common cause of neonatal mortality and morbidity....

    Authors: Asmamaw Demis, Getnet Gedefaw, Adam Wondmieneh, Addisu Getie and Birhan Alemnew

    Citation: BMC Pediatrics 2020 20:217

    Content type: Research article

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  23. Increasingly, neonatal mortality is concentrated in settings of conflict and political instability. To promote evidence-based practices, an interagency collaboration developed the Newborn Health in Humanitaria...

    Authors: Ribka Amsalu, Catherine N. Morris, Michelle Hynes, Hussein Jama Had, Joseph Adive Seriki, Kate Meehan, Stephen Ayella, Sammy O. Barasa, Alexia Couture, Anna Myers and Binyam Gebru

    Citation: BMC Pediatrics 2020 20:215

    Content type: Research article

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  24. One major limitation for less invasive surfactant administration (LISA) is the difficulty in providing sedation before this procedure and the competitive risk of respiratory depression versus avoidance of intu...

    Authors: Marie Chevallier, Xavier Durrmeyer, Anne Ego and Thierry Debillon

    Citation: BMC Pediatrics 2020 20:199

    Content type: Study protocol

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  25. Between 1998 and 2015, we report on the survival of congenital diaphragmatic hernia (CDH)-infants presenting with symptoms within the first 24 h of life, treated at Odense University Hospital (OUH), a tertiary...

    Authors: Ulla Lei Larsen, Søren Jepsen, Thomas Strøm, Niels Qvist and Palle Toft

    Citation: BMC Pediatrics 2020 20:196

    Content type: Research article

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  26. It is important to understand the consequences of pre-emptive antibiotic treatment in neonates, as disturbances in microbiota development during this key developmental time window might affect early and later ...

    Authors: Romy D. Zwittink, Diny van Zoeren-Grobben, Ingrid B. Renes, Richard A. van Lingen, Obbe F. Norbruis, Rocio Martin, Liesbeth J. Groot Jebbink, Jan Knol and Clara Belzer

    Citation: BMC Pediatrics 2020 20:195

    Content type: Research article

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  27. Thyroid hormones play an important role in the normal growth and maturation of the central nervous system. However, few publications addressed the altered thyroid hormone levels in preterm small for gestationa...

    Authors: Chunhua Liu, Kaiyan Wang, Jizhong Guo, Jiru Chen, Mei Chen, Zhexi Xie, Pu Chen, Beiyan Wu and Niyang Lin

    Citation: BMC Pediatrics 2020 20:179

    Content type: Research article

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  28. Systemic fungal infection (SFI) is one of leading causes of morbidity and mortality in very low birth weight (VLBW) preterm infants. Because early diagnosis of SFI is challenging due to nonspecific manifestati...

    Authors: Lily Rundjan, Retno Wahyuningsih, Chrissela Anindita Oeswadi, Miske Marsogi and Ayu Purnamasari

    Citation: BMC Pediatrics 2020 20:170

    Content type: Research article

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  29. The neonatal period carries the highest risk of bacterial meningitis (~ 1 in 5000 births), bearing high mortality (~ 10%) and morbidity (20–50%) rates. Lumbar puncture (LP) remains essential to the diagnosis o...

    Authors: Andrew S. J. Marshall, Manish Sadarangani, Alexandra Scrivens, Rachel Williams, Jean Yong, Ursula Bowler, Louise Linsell, Virginia Chiocchia, Jennifer L. Bell, Caz Stokes, Patricia Santhanadass, Eleri Adams, Edmund Juszczak and Charles C. Roehr

    Citation: BMC Pediatrics 2020 20:165

    Content type: Study protocol

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  30. With the increase in hospitalization of premature infants in emergency departments and the painful procedure in these sectors, appropriate methods of pain relief are required. This study aimed to compare the e...

    Authors: Athareh Ranjbar, Colleen Bernstein, Mamak Shariat and Hadi Ranjbar

    Citation: BMC Pediatrics 2020 20:162

    Content type: Research article

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  31. The first month is the most crucial period for child survival. Neonatal mortality continues to remain high with little improvement over the years in Sub-Saharan Africa, including Ethiopia. This region shows th...

    Authors: Assefa Desalew, Yitagesu Sintayehu, Nardos Teferi, Firehiwot Amare, Bifitu Geda, Teshager Worku, Kebebush Abera and Abiyot Asefaw

    Citation: BMC Pediatrics 2020 20:160

    Content type: Research article

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  32. Lower heart rate variability (HRV) in a newborn might represent a risk factor for unfavourable outcome, a longer recovery after illness, and a sudden infant death. Our aim was to determine whether the newborn’...

    Authors: Petja Fister, Manca Nolimal, Helena Lenasi and Matjaž Klemenc

    Citation: BMC Pediatrics 2020 20:156

    Content type: Research article

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  33. Neonatal hypothermia is a global health problem and a major factor for neonatal morbidity and mortality, especially in low and middle-income countries. Therefore, this systematic review and meta-analysis aimed...

    Authors: Biruk Beletew, Ayelign Mengesha, Mesfin Wudu and Melese Abate

    Citation: BMC Pediatrics 2020 20:148

    Content type: Research article

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  34. Lung recruitment at birth has been advocated as an effective method of improving the respiratory transition at birth. Sustained inflations (SI) and dynamic positive end-expiratory pressure (PEEP) were assessed...

    Authors: Zalfa Kanaan, Coralie Bloch-Queyrat, Marouane Boubaya, Vincent Lévy, Pascal Bolot and Paul Waszak

    Citation: BMC Pediatrics 2020 20:144

    Content type: Research article

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  35. The emerging use of video in neonatology units raises ethical and practical questions. This study aims to gain a better understanding of the suitability, limitations and constraints concerning the use of live ...

    Authors: Aude Le Bris, Nadia Mazille-Orfanos, Pauline Simonot, Maude Luherne, Cyril Flamant, Geraldine Gascoin, Gearóid ÓLaighin, Richard Harte and Patrick Pladys

    Citation: BMC Pediatrics 2020 20:143

    Content type: Research article

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  36. Globally, about 2.7 million neonates die annually and more than 99% of these deaths happened in developing countries. Although most neonatal deaths are preventable and attempts had been taken to tackle these d...

    Authors: Banchigizie Adane Mengistu, Ayenew Engida Yismaw, Zelalem Nigussie Azene and Muhabaw Shumye Mihret

    Citation: BMC Pediatrics 2020 20:142

    Content type: Research article

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  37. Bronchopulmonary dysplasia (BPD) is among the most severe chronic lung diseases and predominantly affects premature infants. There is a general understanding of BPD’s significant impact on the short-term outco...

    Authors: Sasha van Katwyk, Sajit Augustine, Bernard Thébaud and Kednapa Thavorn

    Citation: BMC Pediatrics 2020 20:136

    Content type: Research article

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  38. Despite different preventive strategies that have been implemented in different health institutions in the country, neonatal mortality and morbidity are still significantly increasing in Ethiopia. Perinatal as...

    Authors: Fikadu Waltengus Sendeku, Getnet Gedefaw Azeze and Selamawit Lake Fenta

    Citation: BMC Pediatrics 2020 20:135

    Content type: Research article

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  39. Birth asphyxia accounts for one-quarter newborn deaths. Providing quality care service of neonatal resuscitation reduces neonatal mortality. However, challenges to providing quality neonatal resuscitation are ...

    Authors: Haftom Gebrehiwot Weldearegay, Mulugeta Woldu Abrha, Esayas Haregot Hilawe, Brhane Ayele Gebrekidan and Araya Abrha Medhanyie

    Citation: BMC Pediatrics 2020 20:129

    Content type: Research article

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  40. Meconium peritonitis is defined as aseptic chemical inflammation caused by intrauterine bowel perforation. The underlying causes of bowel perforation include intestinal atresia, midgut volvulus, intussusceptio...

    Authors: Kyung Hee Park, Mi Hye Bae, Na Rae Lee, Young Mi Han, Shin-Yun Byun and Hae-Young Kim

    Citation: BMC Pediatrics 2020 20:106

    Content type: Case report

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  41. Robin sequence (RS) is characterized by mandibular micro- and retrognathia, glossoptosis, upper airway obstruction and optionally a cleft palate. With an incidence of 1:8000, it belongs to the so-called rare d...

    Authors: Silvia Müller-Hagedorn, Jörg Arand, Thilo Scholz, Christian F. Poets and Cornelia Wiechers

    Citation: BMC Pediatrics 2020 20:103

    Content type: Technical advance

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  42. Non-invasive monitoring of cerebral tissue oxygen saturation (rcSO2) during transition is of growing interest. Different near-infrared spectroscopy (NIRS) techniques have been developed to measure rcSO2. We compa...

    Authors: Tanja van Essen, Tom G. Goos, Liza van Ballegooijen, Gerhard Pichler, Berndt Urlesberger, Irwin K. M. Reiss and Rogier C. J. de Jonge

    Citation: BMC Pediatrics 2020 20:94

    Content type: Research article

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  43. Prematurity is the leading cause of mortality in children under 5 years of age globally and is also frequently associated with postnatal growth failure (PGF). Although most preterm births occur in low resource...

    Authors: Clare Nakubulwa, Victor Musiime, Flavia B. Namiiro, James K Tumwine, Christine Hongella, James Nyonyintono, Anna B. Hedstrom and Robert Opoka

    Citation: BMC Pediatrics 2020 20:86

    Content type: Research article

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  44. Clostridium perfringens forms part of the human gut microbiota and has been associated with life-threatening necrotising enterocolitis (NEC) in premature infants. Whether specific toxigenic strains are responsibl...

    Authors: Alexander G. Shaw, Emma Cornwell, Kathleen Sim, Hannah Thrower, Hannah Scott, Joseph C. S. Brown, Ronald A. Dixon and J. Simon Kroll

    Citation: BMC Pediatrics 2020 20:75

    Content type: Research article

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  45. Different charts are used to assess premature growth. The Fenton chart, based on prenatal growth, has been used in the neonates’ intensive care unit (NICU) of the Notre Dame des Secours University Hospital to ...

    Authors: Marie Samarani, Gianna Restom, Joelle Mardini, Georges Abi Fares, Souheil Hallit and Marie-Claude Fadous Khalife

    Citation: BMC Pediatrics 2020 20:74

    Content type: Research article

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  46. Neonatal mortality remains a serious global public health problem, but Sub-Saharan Africa (SSA), in particular, is largely affected. Current evidence on neonatal mortality is essential to inform programs and p...

    Authors: Animut Alebel, Fasil Wagnew, Pammla Petrucka, Cheru Tesema, Nurilign Abebe Moges, Daniel Bekele Ketema, lieltework Yismaw, Mamaru Wubale Melkamu, Yitbarek Tenaw Hibstie, Belisty Temesgen, Zebenay Workneh Bitew, Animen Ayehu Tadesse and Getiye Dejenu Kibret

    Citation: BMC Pediatrics 2020 20:72

    Content type: Research article

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  47. The first consensus standardised neonatal parenteral nutrition formulations were implemented in many neonatal units in Australia in 2012. The current update involving 49 units from Australia, New Zealand, Sing...

    Authors: Srinivas Bolisetty, David Osborn, Tim Schindler, John Sinn, Girish Deshpande, Chee Sing Wong, Susan E. Jacobs, Nilkant Phad, Pramod Pharande, Rodney Tobiansky, Melissa Luig, Amit Trivedi, Joanne Mcintosh, Eszter Josza, Gillian Opie, Lyn Downe…

    Citation: BMC Pediatrics 2020 20:59

    Content type: Correspondence

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  48. Neonatal sepsis is an invasive infection, usually bacterial, and often occurring during the neonatal period (0–28 days). Neonatal sepsis causes a high burden of morbidity and mortality in developing countries ...

    Authors: Amare Belachew and Tilahun Tewabe

    Citation: BMC Pediatrics 2020 20:55

    Content type: Research article

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  50. Improved neonatal care has resulted in increased survival rates among infants born after only 22 gestational weeks, but extremely preterm children still have an increased risk of neurodevelopmental delays, lea...

    Authors: Erika Baraldi, Mara Westling Allodi, Kristina Löwing, Ann-Charlotte Smedler, Björn Westrup and Ulrika Ådén

    Citation: BMC Pediatrics 2020 20:49

    Content type: Study protocol

    Published on:

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