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Section edited by Elizabeth Asztalos

This section considers studies regarding all aspects of neonatal health, disease, care, and outcomes.

Page 1 of 7

  1. Content type: Study protocol

    Patent ductus arteriosus (PDA), the most commonly diagnosed cardiovascular condition in preterm infants, is associated with increased mortality and harmful long-term outcomes (chronic lung disease, neurodevelo...

    Authors: Jonathan L. Slaughter, Clifford L. Cua, Jennifer L. Notestine, Brian K. Rivera, Laura Marzec, Erinn M. Hade, Nathalie L. Maitre, Mark A. Klebanoff, Megan Ilgenfritz, Vi T. Le, Dennis J. Lewandowski and Carl H. Backes

    Citation: BMC Pediatrics 2019 19:333

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  2. Content type: Research article

    Most studies have revealed that the incidence of morbidity and mortality of preterm male infants is greater than that of preterm female infants. Recently, conflicting outcomes have been reported regarding mixe...

    Authors: Bernard Barzilay, Nina Shirman, Haim Bibi and Ibrahim Abu-Kishk

    Citation: BMC Pediatrics 2019 19:328

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  3. Content type: Research article

    Although aminoglycosides are routinely used in neonates, controversy exists regarding empiric dosing regimens. The objectives were to determine gentamicin pharmacokinetics in neonates, and develop initial mg/k...

    Authors: Monique Bergenwall, Sandra A. N. Walker, Marion Elligsen, Dolores C. Iaboni, Carla Findlater, Winnie Seto and Eugene Ng

    Citation: BMC Pediatrics 2019 19:318

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  4. Content type: Research article

    Complications of prematurity are the leading cause of deaths in children under the age of five. The predominant reason for these preterm deaths is respiratory distress syndrome (RDS). In low-income countries (...

    Authors: F. Okello, E. Egiru, J. Ikiror, L. Acom, KSM Loe, P. Olupot-Olupot and K. Burgoine

    Citation: BMC Pediatrics 2019 19:311

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  5. Content type: Research article

    Various types of noninvasive respiratory modalities that lead to successful extubation in preterm infants have been explored. We aimed to compare noninvasive neurally adjusted ventilatory assist (NIV-NAVA) and...

    Authors: Byoung Kook Lee, Seung Han Shin, Young Hwa Jung, Ee-Kyung Kim and Han-Suk Kim

    Citation: BMC Pediatrics 2019 19:298

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  6. Content type: Research article

    In high syphilis prevalence settings, the syphilis testing and treatment strategy for mothers and newborns must be tailored to balance the risk of over treatment against the risk of missing infants at high-ris...

    Authors: Oluwakemi F. Ogundipe, Rafael Van den Bergh, Behounde Thierry, Kudakwashe C. Takarinda, Claude P. Muller, Collins Timire, Severine Caluwaerts, Pascale Chaillet and Isabel Zuniga

    Citation: BMC Pediatrics 2019 19:284

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  7. Content type: Case report

    Pulmonary interstitial emphysema (PIE) in very low birth weight infants is a rare but severe complication. Although most of these air leaks develop in mechanically ventilated infants, they have also been repor...

    Authors: Xiaoping Lei, Oliver Stangl, Christina Bösche, Kristina Stuchlik, Roland Czorba and Christian Wieg

    Citation: BMC Pediatrics 2019 19:267

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  8. Content type: Case report

    Streptococcus pasteurianus is a rare cause of neonatal infection, with only 3 cases reported in the USA and 18 cases reported in other countries within the past decade. Neonatal S. pasteurianus infection typicall...

    Authors: Michelle T. Nguyen, Soha Idriss, Ernie Guzman and Elizabeth R. De Oliveira

    Citation: BMC Pediatrics 2019 19:265

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  9. Content type: Study protocol

    Various noninvasive respiratory support modalities are available in neonatal critical care in order to minimize invasive ventilation. Continuous positive airway pressure (CPAP) is the more commonly used but no...

    Authors: Yuan Shi and Daniele De Luca

    Citation: BMC Pediatrics 2019 19:256

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  10. Content type: Research article

    The current standard treatment of neonates with intestinal perforation is surgery. However, the mortality rate after surgical treatment for intestinal perforation is very high for very low birth weight (VLBW) ...

    Authors: Nan Ye, Yurong Yuan, Lei Xu, Riccardo E. Pfister and Chuanzhong Yang

    Citation: BMC Pediatrics 2019 19:255

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  11. Content type: Research article

    Clinical and laboratory parameters can aid in the early identification of neonates at risk for bacteremia before clinical deterioration occurs. However, current prediction models have poor diagnostic capabilit...

    Authors: Sandra A. N. Walker, Melanie Cormier, Marion Elligsen, Julie Choudhury, Asaph Rolnitsky, Carla Findlater and Dolores Iaboni

    Citation: BMC Pediatrics 2019 19:253

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  12. Content type: Research article

    Neonatal hypothermia plays a significant role in increasing neonatal death by 80% for every 1 degree Celsius decrease of body temperature, especially in sub Saharan countries. A global burden of neonatal hypot...

    Authors: Wubet Alebachew Bayih, Nega Assefa, Merga Dheresa, Biniam Minuye and Solomon Demis

    Citation: BMC Pediatrics 2019 19:252

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  13. Content type: Research article

    Several studies have investigated heart rate variability (HRV) as a biomarker for acute brain injury in hypoxic ischemic encephalopathy (HIE). However, the current evidence is heterogeneous and needs further r...

    Authors: Mads Andersen, Ted C. K. Andelius, Mette V. Pedersen, Kasper J. Kyng and Tine B. Henriksen

    Citation: BMC Pediatrics 2019 19:242

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  14. Content type: Study protocol

    Premature birth is a growing and serious public health problem affecting more than one of every ten infants worldwide. Bronchopulmonary dysplasia (BPD) is the most common neonatal morbidity associated with pre...

    Authors: Gaston Ofman, Mauricio T. Caballero, Damian Alvarez Paggi, Jacqui Marzec, Florencia Nowogrodzki, Hye-Youn Cho, Mariana Sorgetti, Guillermo Colantonio, Alejandra Bianchi, Luis M. Prudent, Nestor Vain, Gonzalo Mariani, Jorge Digregorio, Elba Lopez Turconi, Cristina Osio, Fernanda Galletti…

    Citation: BMC Pediatrics 2019 19:227

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  15. Content type: Research article

    We have limited information on families’ experiences during transition and after discharge from the neonatal intensive care unit.

    Authors: Ashwini Lakshmanan, Katrina Kubicek, Roberta Williams, Marisela Robles, Douglas L. Vanderbilt, Christine B. Mirzaian, Philippe S. Friedlich and Michele Kipke

    Citation: BMC Pediatrics 2019 19:223

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  16. Content type: Case report

    Cyanosis is usually associated with serious conditions requiring urgent treatment in the neonatal intensive care unit (NICU). Hemoglobin M (Hb M) disease is one type of congenital methemoglobinemia characteriz...

    Authors: Chungwoo Shin, Mee Hong, Myungshin Kim and Jung Hyun Lee

    Citation: BMC Pediatrics 2019 19:221

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  17. Content type: Research article

    It has been established that genetic factors play a substantial role in the development of neonatal hyperbilirubinemia. The population of Indonesia and other Southeast Asian countries has similar, yet differen...

    Authors: Radhian Amandito, Rinawati Rohsiswatmo, Michelle Halim, Vanessa Tirtatjahja and Amarila Malik

    Citation: BMC Pediatrics 2019 19:212

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  18. Content type: Study protocol

    Perinatal asphyxia and resulting hypoxic-ischemic encephalopathy is a major cause of death and long-term disability in term born neonates. Up to 20,000 infants each year are affected by HIE in Europe and even ...

    Authors: Christian A. Maiwald, Kim V. Annink, Mario Rüdiger, Manon J. N. L. Benders, Frank van Bel, Karel Allegaert, Gunnar Naulaers, Dirk Bassler, Katrin Klebermaß-Schrehof, Maximo Vento, Hercilia Guimarães, Tom Stiris, Luigi Cattarossi, Marjo Metsäranta, Sampsa Vanhatalo, Jan Mazela…

    Citation: BMC Pediatrics 2019 19:210

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  19. Content type: Case report

    The authors report a 1 month follow up of a neonate described as “miracle baby” because she was born Ebola virus disease-free and survived after her mother was infected with Ebola virus during the third trimes...

    Authors: N. Kasereka Baraka, Mupenzi Mumbere and Evie Ndombe

    Citation: BMC Pediatrics 2019 19:202

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  20. Content type: Research article

    In Indonesia, the burden of severe hyperbilirubinemia is higher compared to other countries. Whether this is related to ineffective phototherapy (PT) is unknown. The aim of this study is to investigate the per...

    Authors: Mahendra T. A. Sampurna, Kinanti A. Ratnasari, Darto Saharso, Arend F. Bos, Pieter J. J. Sauer, Peter H. Dijk and Christian V. Hulzebos

    Citation: BMC Pediatrics 2019 19:188

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  21. Content type: Research article

    Probiotic therapy can reduce the incidence of NEC. Therapeutic use of probiotics after NEC diagnosis reduces the severity of NEC in preterm infants or full-term infants is unclear. To evaluate the effect of pr...

    Authors: Zheng-Li Wang, Li Liu, Xiao-Yu Hu, Lu Guo, Qiu-Yu Li, Yao An, Ya-Jun Jiang, Shi Chen, Xue-Qiu Wang, Yu He and Lu-Quan Li

    Citation: BMC Pediatrics 2019 19:185

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  22. Content type: Research article

    Infants with hemodynamically significant patent ductus arteriosus (PDA) may physiologically compensate with a supranormal cardiac output (CO). As such, a supranormal CO may be a surrogate marker for a signific...

    Authors: Kai-Hsiang Hsu, Tai-Wei Wu, I-Hsyuan Wu, Mei-Yin Lai, Shih-Yun Hsu, Hsiao-Wen Huang, Tze-Yee Mok, Cheng-Chung Lee and Reyin Lien

    Citation: BMC Pediatrics 2019 19:179

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  23. Content type: Research article

    Prolonged neonatal jaundice (PNNJ) is often caused by breast milk jaundice, but it could also point to other serious conditions (biliary atresia, congenital hypothyroidism). When babies with PNNJ receive a rou...

    Authors: Hui-Siu Tan, Inthira-Sankari Balasubramaniam, Amar-Singh HSS, May-Luu Yeong, Chii-Chii Chew, Ranjit-Kaur Praim Singh, Ai-Yuin Leow, Fatimahtuz-Zahrah Muhamad Damanhuri and Santhi Verasingam

    Citation: BMC Pediatrics 2019 19:174

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  24. Content type: Research article

    Current guidelines for management of respiratory distress syndrome (RDS) recommend continuous positive airway pressure (CPAP) as the primary mode of respiratory support even in the most premature neonates, res...

    Authors: Fernando R. Moya, Jan Mazela, Paul M. Shore, Steven G. Simonson, Robert Segal, Phillip D. Simmons, Timothy J. Gregory, Carlos G. Guardia, Judy R. Varga and Neil N. Finer

    Citation: BMC Pediatrics 2019 19:147

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  25. Content type: Research article

    Changes in oxygen saturation (SpO2) exposure have been shown to have a marked impact on neonatal outcomes and therefore careful titration of inspired oxygen is essential. In routine use, however, the frequency of...

    Authors: Malgorzata Warakomska, Thomas E Bachman and Maria Wilinska

    Citation: BMC Pediatrics 2019 19:142

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  26. Content type: Research article

    To evaluate the association between hematological parameters at birth and the risk of moderate-severe bronchopulmonary dysplasia (BPD) in a cohort of extremely preterm infants.

    Authors: Xueyu Chen, Huitao Li, Xiaomei Qiu, Chuanzhong Yang and Frans J. Walther

    Citation: BMC Pediatrics 2019 19:138

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  27. Content type: Research article

    No guidelines exist concerning the maintenance antiepileptic drug to use after neonatal seizures. Practices vary from one hospital to another. The aim of this study was to investigate etiologies and to report ...

    Authors: E. Baudou, C. Cances, C. Dimeglio and C. Hachon Lecamus

    Citation: BMC Pediatrics 2019 19:136

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  28. Content type: Correspondence

    This letter has been written by the components of the European Milk Bank Association (EMBA) Working Group on Human Milk Fortification in response to a recent paper published by Mathes et al. (BMC Pediatr. 2018...

    Authors: Sertac Arslanoglu, Caroline King, Clair-Yves Boquien, Delphine Lamireau, Paola Tonetto, Barbara Krolak-Olejnik and Jean-Charles Picaud

    Citation: BMC Pediatrics 2019 19:135

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  29. Content type: Research article

    Any event involving drug therapy that may interfere in a patient’s desired clinical outcome is called a drug related problem (DRP). DRP are very common in intensive therapy, however, little is known about DRP ...

    Authors: Ramon Duarte Leopoldino, Marco Tavares Santos, Tatiana Xavier Costa, Rand Randall Martins and António Gouveia Oliveira

    Citation: BMC Pediatrics 2019 19:134

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  30. Content type: Research article

    Despite significant advances in neonatology, bronchopulmonary dysplasia (BPD) remains the most common cause of serious morbidity and mortality in premature infants. The aim of the present study was to determin...

    Authors: Young Hwa Jung, Jinhee Jang, Han-Suk Kim, Seung Han Shin, Chang Won Choi, Ee-Kyung Kim and Beyong Il Kim

    Citation: BMC Pediatrics 2019 19:121

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    The Correction to this article has been published in BMC Pediatrics 2019 19:263

  31. Content type: Research article

    Antimicrobial stewardship programs potentially lead to appropriate antibiotic use, yet the optimal approach for neonates is uncertain. Such a program was implemented in a tertiary care neonatal intensive care ...

    Authors: Nisha Thampi, Prakesh S. Shah, Sandra Nelson, Amisha Agarwal, Marilyn Steinberg, Yenge Diambomba and Andrew M. Morris

    Citation: BMC Pediatrics 2019 19:105

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  32. Content type: Study protocol

    Premature infants are at risk for abnormal sensory development due to brain immaturity at birth and atypical early sensory experiences in the Neonatal Intensive Care Unit. This altered sensory development can ...

    Authors: Mary Lauren Neel, Paul Yoder, Pawel J. Matusz, Micah M. Murray, Ashley Miller, Stephanie Burkhardt, Lelia Emery, Kaleigh Hague, Caitlin Pennington, Jessica Purnell, Megan Lightfoot and Nathalie L. Maitre

    Citation: BMC Pediatrics 2019 19:81

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  33. Content type: Case report

    Maternofetal carnitine transport through the placenta is the main route of fetal carnitine uptake. Decreased free carnitine levels discovered by newborn screening has identified many asymptomatic adult women w...

    Authors: Si Chen, Yingying Hu, Yumei Huang, Yan Nan, Xiaojian Zhou, Shangqin Chen, Jin Lin and Zhenlang Lin

    Citation: BMC Pediatrics 2019 19:79

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  34. Content type: Research article

    Comprehensive data are needed to evaluate the burden of low birthweight. Analysis of routine data on health-care utilization during early childhood were used to test the hypothesis that infants with low birthw...

    Authors: Mario Rüdiger, Luise Heinrich, Katrin Arnold, Diana Druschke, Jörg Reichert and Jochen Schmitt

    Citation: BMC Pediatrics 2019 19:69

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  35. Content type: Research article

    While intercenter variation (ICV) in anti-epileptic drug (AED) use in neonates with seizures has been previously reported, variation in AED practices across regional NICUs has not been specifically and systema...

    Authors: Maria L. V. Dizon, Rakesh Rao, Shannon E. Hamrick, Isabella Zaniletti, Robert DiGeronimo, Girija Natarajan, Jeffrey R. Kaiser, John Flibotte, Kyong-Soon Lee, Danielle Smith, Toby Yanowitz, Amit M. Mathur and An N. Massaro

    Citation: BMC Pediatrics 2019 19:67

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  36. Content type: Research article

    Prevalence of hemolytic neonatal hyperbilirubinemia (NHB) is not well characterized, and economic burden at the population level is poorly understood. This study evaluated the prevalence, clinical characterist...

    Authors: Tzy-Chyi Yu, Chi Nguyen, Nancy Ruiz, Siting Zhou, Xian Zhang, Elaine A. Böing and Hiangkiat Tan

    Citation: BMC Pediatrics 2019 19:53

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  37. Content type: Case report

    Pneumomediastinum is an uncommon cause of neonatal respiratory distress. Clinical history and examination of the neonate may be uninformative in determining the aetiology of the respiratory distress. Chest x-r...

    Authors: Stephen Sze Shing Teo, Archana Priyadarshi and Kathryn Browning Carmo

    Citation: BMC Pediatrics 2019 19:38

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  38. Content type: Research article

    Owing to advances in the critical care of premature infants with bronchopulmonary dysplasia (BPD), BPD-associated pulmonary hypertension (PH) is becoming a growing concern. However, only few investigations wer...

    Authors: Eui Kyung Choi, Seung Han Shin, Ee-Kyung Kim and Han-Suk Kim

    Citation: BMC Pediatrics 2019 19:26

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  39. Content type: Research article

    Assessing pain in neonates is challenging because full-term and preterm neonates of different gestational ages (GAs) have widely varied reactions to pain. We validated the Bernese Pain Scale for Neonates (BPSN...

    Authors: Karin Schenk, Liliane Stoffel, Reto Bürgin, Bonnie Stevens, Dirk Bassler, Sven Schulzke, Mathias Nelle and Eva Cignacco

    Citation: BMC Pediatrics 2019 19:20

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  40. Content type: Research article

    Substantial numbers of neonates with hypoxic respiratory failure (HRF) do not immediately respond to inhaled nitric oxide (iNO) and are often labeled as non-responders. This retrospective data analysis assesse...

    Authors: Leif D. Nelin and Jim L. Potenziano

    Citation: BMC Pediatrics 2019 19:17

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  41. Content type: Research article

    Although therapeutic hypothermia improves the outcome of neonatal hypoxic-ischemic encephalopathy (HIE), its efficacy is still limited. This preliminary study evaluates the safety and feasibility of the combin...

    Authors: Miho Nonomura, Sayaka Harada, Yuki Asada, Hisako Matsumura, Hiroko Iwami, Yuko Tanaka and Hiroyuki Ichiba

    Citation: BMC Pediatrics 2019 19:13

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  42. Content type: Research article

    Many newborns may need to be hospitalized and receive drugs during the first days of their lives. These drugs are fundamentally prescribed as off-label and unlicensed. This study aimed to investigate the amoun...

    Authors: Leila Kouti, Maryam Aletayeb, Seyyed Mohammad Hassan Aletayeb, Amir Kamal Hardani and Kaveh Eslami

    Citation: BMC Pediatrics 2019 19:3

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