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Neonatology

Section edited by Elizabeth Asztalos

This section considers studies regarding all aspects of neonatal health, disease, care, and outcomes.

Page 1 of 9

  1. Early-onset sepsis (EOS) is a potentially life-threatening complication of birth. Clinical symptoms are often unspecific and biomarkers have low predictive values for EOS. Therefore, clinical suspicion often l...

    Authors: Johan Gyllensvärd, Fredrik Ingemansson, Elisabet Hentz, Marie Studahl and Anders Elfvin

    Citation: BMC Pediatrics 2020 20:531

    Content type: Research article

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  2. Human milk has potential protective effects against bronchopulmonary dysplasia (BPD). However, studies on the association between the dose of human milk and BPD in China are limited. This study aimed to evalua...

    Authors: Yan Xu, Zhangbin Yu, Qianqian Li, Jinjun Zhou, Xiaoguang Yin, Yuelan Ma, Yujie Yin, Shanyu Jiang, Rongping Zhu, Yue Wu, Liangrong Han, Yan Gao, Mei Xue, Yu Qiao, Lingling Zhu, Wenjuan Tu…

    Citation: BMC Pediatrics 2020 20:522

    Content type: Research article

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  3. Intraventricular hemorrhage during the early stage is a major complication in very low birth weight infants. Elevation of venous pressure is one of the contributing factors. The internal cerebral vein receives...

    Authors: Kenichi Tanaka, Rieko Sakamoto, Hiroko Imamura, Tetsuo Naramura, Shirou Matsumoto, Masanori Iwai, Hiroshi Mitsubuchi and Kimitoshi Nakamura

    Citation: BMC Pediatrics 2020 20:517

    Content type: Case report

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  4. Very low birth weight (VLBW) infant thermal instability upon neonatal intensive care unit admission has been associated with respiratory morbidity; however, the association between ongoing thermal instability ...

    Authors: Jane L. Ralphe, Susan G. Silva, Robin B. Dail and Debra H. Brandon

    Citation: BMC Pediatrics 2020 20:485

    Content type: Research article

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  5. During the first period of life, critically ill as well as healthy newborn infants experience recurrent painful procedures. Parents are a valuable but often overlooked resource in procedural pain management in...

    Authors: Emma Olsson, Martina Carlsen Misic, Randi Dovland Andersen, Jenny Ericson, Mats Eriksson, Ylva Thernström Blomqvist and Alexandra Ullsten

    Citation: BMC Pediatrics 2020 20:474

    Content type: Study protocol

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  6. No consensus has been reached on capillary blood reference intervals for platelet parameters in full-term neonates. We aimed to establish neonatal capillary blood reference intervals for platelet parameters an...

    Authors: Dongyan Cui, Yan Hou, Ling Feng, Guo Li, Chi Zhang, Yanli Huang, Jiubo Fan and Qun Hu

    Citation: BMC Pediatrics 2020 20:471

    Content type: Research article

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  7. The high proportion of birth weight in Ethiopia is hypothesized to be due to inadequate maternal diet which is associated with poor nutrition education during pregnancy. There was no study that evaluated the e...

    Authors: Yeshalem Mulugeta Demilew, Getu Degu Alene and Tefera Belachew

    Citation: BMC Pediatrics 2020 20:466

    Content type: Research article

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  9. In preterm infants with Respiratory Distress Syndrome (RDS), Less Invasive Surfactant Administration (LISA) has been established to reduce the need of mechanical ventilation and might improve survival rates wi...

    Authors: I. A. L. Bugter, L. C. E. Janssen, J. Dieleman, B. W. Kramer, P. Andriessen and H. J. Niemarkt

    Citation: BMC Pediatrics 2020 20:421

    Content type: Research article

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  12. Neonatal mortality is high in developing countries. Lack of adequate training and insufficient management skills for sick newborn care contribute to these deaths. We developed a phone application dubbed Protec...

    Authors: Santorino Data, Martin Mukama, Douglas McMillan, Nalini Singhal and Francis Bajunirwe

    Citation: BMC Pediatrics 2020 20:406

    Content type: Research article

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  13. Venous access during neonatal emergencies in the delivery room (DR) can be accomplished through an umbilical venous catheter (UVC) or an intraosseous (IO) access. Preference of one over the other is unclear. W...

    Authors: Bianca Haase, Laila Springer and Christian Friedrich Poets

    Citation: BMC Pediatrics 2020 20:405

    Content type: Research article

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  14. Preterm infants born 30 to 33 weeks’ gestation often require early support with intravenous fluids because of respiratory distress, hypoglycemia or feed intolerance. When full feeds are anticipated to be reach...

    Authors: Hiroki Suganuma, Dennis Bonney, Chad C. Andersen, Andrew J. McPhee, Thomas R. Sullivan, Robert A. Gibson and Carmel T. Collins

    Citation: BMC Pediatrics 2020 20:384

    Content type: Research article

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  15. The oropharyngeal colostrum administration protocol to treat premature newborns is a possible and plausible strategy in neonatal health services, since the immunoprotective components of colostrum can be absor...

    Authors: Camilla da Cruz Martins, Michelle de Santana Xavier Ramos, Mara Viana Cardoso Amaral, Jéssica Santos Passos Costa, Ellayne Souza Cerqueira, Tatiana de Oliveira Vieira, Simone Seixas dA Cruz and Graciete Oliveira Vieira

    Citation: BMC Pediatrics 2020 20:371

    Content type: Study protocol

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  16. Atrial flutter (AFL) is a supraventricular tachyarrhythmia. In the ECG tracing, it is marked by a fast, irregular atrial activity of 280–500 beats per minute. AFL is known to be a rare and also life-threatenin...

    Authors: Monika Wójtowicz-Marzec, Barbara Wysokińska and Maria Respondek-Liberska

    Citation: BMC Pediatrics 2020 20:370

    Content type: Case report

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  17. Congenital diaphragmatic hernia is a deficiency of the fetal diaphragm resulting in herniation of the abdominal viscera into the thoracic cavity. The best method of respiratory management of congenital diaphra...

    Authors: Sasagu Kimura, Katsuaki Toyoshima, Tomoaki Shimokaze and Rikuo Hoshino

    Citation: BMC Pediatrics 2020 20:365

    Content type: Case report

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  18. Phenylketonuria (PKU), which is characterized by a deficiency of phenylalanine hydroxylase activity, is an autosomal recessive disorder of phenylalanine (Phe) metabolism. Newborn screening is the main populati...

    Authors: Mehdi Shokri, Parviz Karimi, Hadis Zamanifar, Fatemeh Kazemi, Gholamreza Badfar and Milad Azami

    Citation: BMC Pediatrics 2020 20:352

    Content type: Research article

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  19. Necrotising Enterocolitis (NEC) is a devastating neonatal disease. A temporal association between red cell transfusion and NEC has been recognized and there have been concerns about the effects of feeding duri...

    Authors: Tim Schindler, Kee Thai Yeo, Srinivas Bolisetty, Joanna Michalowski, Alvin Hock Kuan Tan and Kei Lui

    Citation: BMC Pediatrics 2020 20:346

    Content type: Research article

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  22. Idiopathic or transient neonatal cholestasis (TNC) represents a group of cholestatic disorders with unidentified origin and remains a diagnosis of exclusion. Dysfunction of hepatobiliary transporters mediating...

    Authors: Anna Baghdasaryan, Lisa Ofner-Ziegenfuß, Carolin Lackner, Peter Fickert, Bernhard Resch, Nicholas Mark Morris and Andrea Deutschmann

    Citation: BMC Pediatrics 2020 20:340

    Content type: Case report

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  23. Choroid plexus papillomas (CPPs) are rare, usually benign, neoplasms originating in the central nervous system. In this study, we present the first case of a giant airway-obstructing CPP in the pharynx of a ne...

    Authors: Narae Lee, Mi Hye Bae, Young Mi Han, Kyung Hee Park, Jae-Yeon Hwang, Cheong-Soo Hwang, Jin-Choon Lee and Shin Yun Byun

    Citation: BMC Pediatrics 2020 20:336

    Content type: Case report

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  24. Roughly 10% of newborns need help to complete the transition of birth. For these infants, international guidelines recommend supporting them using a 4-step procedure (A to D). Step A is an assessment time, whi...

    Authors: Claire Boithias, Laure Jule, Stephanie Le Foulgoc, Gilles Jourdain and Dan Benhamou

    Citation: BMC Pediatrics 2020 20:331

    Content type: Research article

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  25. The objective of this prospective, multicentre, observational cohort study was to evaluate the association between admission hypothermia and neonatal outcomes in very low-birth weight (VLBW) infants in multipl...

    Authors: Yong-hui Yu, Li Wang, Lei Huang, Li-ling Wang, Xiao-yang Huang, Xiu-fang Fan, Yan-jie Ding, Cheng-yuan Zhang, Qiang Liu, Ai-rong Sun, Yue-hua Zhao, Guo Yao, Cong Li, Xiu-xiang Liu, Jing-cai Wu, Zhen-ying Yang…

    Citation: BMC Pediatrics 2020 20:321

    Content type: Research article

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  26. Alveolar capillary dysplasia (ACD) is a rare cause of severe pulmonary hypertension and respiratory failure in neonates. The onset of ACD is usually preceded by a short asymptomatic period. The condition is re...

    Authors: Zuzanna Kozłowska, Zuzanna Owsiańska, Joanna P. Wroblewska, Apolonia Kałużna, Andrzej Marszałek, Yogen Singh, Bartłomiej Mroziński, Qian Liu, Justyna A. Karolak, Paweł Stankiewicz, Gail Deutsch, Marta Szymankiewicz-Bręborowicz and Tomasz Szczapa

    Citation: BMC Pediatrics 2020 20:320

    Content type: Case report

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  27. Continuous monitoring of SpO2 in the neonatal ICU is the standard of care. Changes in SpO2 exposure have been shown to markedly impact outcome, but limiting extreme episodes is an arduous task. Much more complica...

    Authors: Thomas E. Bachman, Narayan P. Iyer, Christopher J. L. Newth, Patrick A. Ross and Robinder G. Khemani

    Citation: BMC Pediatrics 2020 20:317

    Content type: Research article

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  28. Globally, possible serious bacterial infection [PSBI] is a cause for about 600,000 newborn deaths per year. To decrease the burden of this infection, a community-based management newborn PSBI when referral to ...

    Authors: Kasahun Girma Tareke, Yohannes Kebede Lemu and Garumma Tolu Feyissa

    Citation: BMC Pediatrics 2020 20:303

    Content type: Research article

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  29. Developmental dysplasia of the hip (DDH) is a common disorder in infants. The present study aimed to evaluate the efficacy and safety of the Tübingen hip flexion splints in treating DDH in infants aged 0–6 mon...

    Authors: You Zhou, Rong Li, Chuan Li, Ping Zhou, Yan Li, You-hao Ke, Fei Jiang and Xiao-peng Kang

    Citation: BMC Pediatrics 2020 20:280

    Content type: Research article

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  31. This study aimed to describe the causative organisms of neonatal late-onset sepsis (LOS) and their antimicrobial resistance in Suzhou, Southeast China over a 7-year period.

    Authors: Tao Pan, Qiujiao Zhu, Pei Li, Jun Hua and Xing Feng

    Citation: BMC Pediatrics 2020 20:261

    Content type: Research article

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  32. Necrotizing enterocolitis (NEC) is associated with significant morbidity and mortality. Serum biomarkers to aid diagnosis, such as intestinal fatty acid binding protein (IFABP) and calprotectin, are actively b...

    Authors: Darla R. Shores, Jennifer Fundora, Mitzi Go, Fauzia Shakeel, Sandra Brooks, Samuel M. Alaish, Jun Yang, Chhinder P. Sodhi, David J. Hackam and Allen Everett

    Citation: BMC Pediatrics 2020 20:250

    Content type: Research article

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  33. The guidelines of the American Academy of Pediatrics (AAP) for monitoring neonatal jaundice recommend universal postnatal screening for hyperbilirubinemia within 48 h from discharge. We observed that neonate w...

    Authors: Amit Blumovich, Laurence Mangel, Sivan Yochpaz, Dror Mandel and Ronella Marom

    Citation: BMC Pediatrics 2020 20:248

    Content type: Research article

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  34. The relation between mechanical ventilation (MV) and bronchopulmonary dysplasia (BPD) - a common disease in extremely premature newborn (PTNB) - is well stabilished, but is unknown, however, how much time unde...

    Authors: Victoria Escobar, Darllyana S. Soares, Jane Kreling, Ligia S. L. Ferrari, Josiane M. Felcar, Carlos A. M. Camillo and Vanessa S. Probst

    Citation: BMC Pediatrics 2020 20:241

    Content type: Research article

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  35. Early warning scores for neonatal mortality have not been designed for low income countries. We developed and validated a score to predict mortality upon admission to a NICU in Ethiopia.

    Authors: Rishi P. Mediratta, Ashenafi Tazebew Amare, Rasika Behl, Bradley Efron, Balasubramanian Narasimhan, Alemayehu Teklu, Abdulkadir Shehibo, Mulugeta Ayalew and Saraswati Kache

    Citation: BMC Pediatrics 2020 20:238

    Content type: Research article

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  36. Donor human milk (DHM) has been recommended for premature infants if mothers’ own milk is not available. The aim of this study was to increase the knowledge about the utilization rate and handling of DHM among...

    Authors: Daniel Klotz, Stefanie Jansen, René Glanzmann, Nadja Haiden, Hans Fuchs and Corinna Gebauer

    Citation: BMC Pediatrics 2020 20:235

    Content type: Research article

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  37. Respiratory distress syndrome (RDS) is a frequent complication of premature birth. Treating RDS by continuous positive airway pressure and less invasive surfactant administration (LISA) may reduce bronchopulmo...

    Authors: Christian A. Maiwald, Julia Dick, Matthias Marschal, Christian Gille, Axel R. Franz and Christian F. Poets

    Citation: BMC Pediatrics 2020 20:234

    Content type: Research article

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  38. Reducing neonatal mortality is an essential part of the third Sustainable Development Goal, to end preventable child deaths. Neonatal danger signs are the most common cause of neonatal mortality and morbidity....

    Authors: Asmamaw Demis, Getnet Gedefaw, Adam Wondmieneh, Addisu Getie and Birhan Alemnew

    Citation: BMC Pediatrics 2020 20:217

    Content type: Research article

    Published on:

  39. Increasingly, neonatal mortality is concentrated in settings of conflict and political instability. To promote evidence-based practices, an interagency collaboration developed the Newborn Health in Humanitaria...

    Authors: Ribka Amsalu, Catherine N. Morris, Michelle Hynes, Hussein Jama Had, Joseph Adive Seriki, Kate Meehan, Stephen Ayella, Sammy O. Barasa, Alexia Couture, Anna Myers and Binyam Gebru

    Citation: BMC Pediatrics 2020 20:215

    Content type: Research article

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  40. One major limitation for less invasive surfactant administration (LISA) is the difficulty in providing sedation before this procedure and the competitive risk of respiratory depression versus avoidance of intu...

    Authors: Marie Chevallier, Xavier Durrmeyer, Anne Ego and Thierry Debillon

    Citation: BMC Pediatrics 2020 20:199

    Content type: Study protocol

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  41. Between 1998 and 2015, we report on the survival of congenital diaphragmatic hernia (CDH)-infants presenting with symptoms within the first 24 h of life, treated at Odense University Hospital (OUH), a tertiary...

    Authors: Ulla Lei Larsen, Søren Jepsen, Thomas Strøm, Niels Qvist and Palle Toft

    Citation: BMC Pediatrics 2020 20:196

    Content type: Research article

    Published on:

  42. It is important to understand the consequences of pre-emptive antibiotic treatment in neonates, as disturbances in microbiota development during this key developmental time window might affect early and later ...

    Authors: Romy D. Zwittink, Diny van Zoeren-Grobben, Ingrid B. Renes, Richard A. van Lingen, Obbe F. Norbruis, Rocio Martin, Liesbeth J. Groot Jebbink, Jan Knol and Clara Belzer

    Citation: BMC Pediatrics 2020 20:195

    Content type: Research article

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  43. Thyroid hormones play an important role in the normal growth and maturation of the central nervous system. However, few publications addressed the altered thyroid hormone levels in preterm small for gestationa...

    Authors: Chunhua Liu, Kaiyan Wang, Jizhong Guo, Jiru Chen, Mei Chen, Zhexi Xie, Pu Chen, Beiyan Wu and Niyang Lin

    Citation: BMC Pediatrics 2020 20:179

    Content type: Research article

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  44. Systemic fungal infection (SFI) is one of leading causes of morbidity and mortality in very low birth weight (VLBW) preterm infants. Because early diagnosis of SFI is challenging due to nonspecific manifestati...

    Authors: Lily Rundjan, Retno Wahyuningsih, Chrissela Anindita Oeswadi, Miske Marsogi and Ayu Purnamasari

    Citation: BMC Pediatrics 2020 20:170

    Content type: Research article

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  45. The neonatal period carries the highest risk of bacterial meningitis (~ 1 in 5000 births), bearing high mortality (~ 10%) and morbidity (20–50%) rates. Lumbar puncture (LP) remains essential to the diagnosis o...

    Authors: Andrew S. J. Marshall, Manish Sadarangani, Alexandra Scrivens, Rachel Williams, Jean Yong, Ursula Bowler, Louise Linsell, Virginia Chiocchia, Jennifer L. Bell, Caz Stokes, Patricia Santhanadass, Eleri Adams, Edmund Juszczak and Charles C. Roehr

    Citation: BMC Pediatrics 2020 20:165

    Content type: Study protocol

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  46. With the increase in hospitalization of premature infants in emergency departments and the painful procedure in these sectors, appropriate methods of pain relief are required. This study aimed to compare the e...

    Authors: Athareh Ranjbar, Colleen Bernstein, Mamak Shariat and Hadi Ranjbar

    Citation: BMC Pediatrics 2020 20:162

    Content type: Research article

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  47. The first month is the most crucial period for child survival. Neonatal mortality continues to remain high with little improvement over the years in Sub-Saharan Africa, including Ethiopia. This region shows th...

    Authors: Assefa Desalew, Yitagesu Sintayehu, Nardos Teferi, Firehiwot Amare, Bifitu Geda, Teshager Worku, Kebebush Abera and Abiyot Asefaw

    Citation: BMC Pediatrics 2020 20:160

    Content type: Research article

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  48. Lower heart rate variability (HRV) in a newborn might represent a risk factor for unfavourable outcome, a longer recovery after illness, and a sudden infant death. Our aim was to determine whether the newborn’...

    Authors: Petja Fister, Manca Nolimal, Helena Lenasi and Matjaž Klemenc

    Citation: BMC Pediatrics 2020 20:156

    Content type: Research article

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  49. Neonatal hypothermia is a global health problem and a major factor for neonatal morbidity and mortality, especially in low and middle-income countries. Therefore, this systematic review and meta-analysis aimed...

    Authors: Biruk Beletew, Ayelign Mengesha, Mesfin Wudu and Melese Abate

    Citation: BMC Pediatrics 2020 20:148

    Content type: Research article

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  50. Globally, about 2.7 million neonates die annually and more than 99% of these deaths happened in developing countries. Although most neonatal deaths are preventable and attempts had been taken to tackle these d...

    Authors: Banchigizie Adane Mengistu, Ayenew Engida Yismaw, Zelalem Nigussie Azene and Muhabaw Shumye Mihret

    Citation: BMC Pediatrics 2020 20:142

    Content type: Research article

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