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General pediatric medicine and surgery

This section considers studies of general medicine and surgical intervention in children and adolescents.

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  1. Growing evidence shows that atopic dermatitis (AD), food allergy (FA), allergic rhinitis, and asthma are largely determined during the first 1000 days (time elapsed from conception to the 2nd birthday). The AR...

    Authors: Caroll D. Hernández, Paola Casanello, Paul R. Harris, José A. Castro-Rodríguez, Carolina Iturriaga, Guillermo Perez-Mateluna, Marcelo Farías, Marcela Urzúa, Cherie Hernandez, Carolina Serrano, Mauricio Sandoval, Rodrigo Hoyos-Bachiloglu, Ricardo Uauy and Arturo Borzutzky

    Citation: BMC Pediatrics 2020 20:164

    Content type: Study protocol

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  5. Recruiting patients to paediatric trials can be challenging, especially in trials that compare markedly different management pathways and are conducted in acute settings. We aimed to enhance informed consent a...

    Authors: Frances C. Sherratt, Lucy Beasant, Esther M. Crawley, Nigel J. Hall and Bridget Young

    Citation: BMC Pediatrics 2020 20:140

    Content type: Research article

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  7. Hyperbilirubinemia is a common neonatal problem. Studies conducted on the effectiveness of zinc salts on serum indirect bilirubin levels in newborns have yielded different results, all calling for further rese...

    Authors: Gholamreza Faal, Hoda Khatib Masjedi, Gholamreza Sharifzadeh and Zahra Kiani

    Citation: BMC Pediatrics 2020 20:130

    Content type: Research article

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  9. The purpose of this study was to describe clinical presentation, epilepsy, EEG, extent and site of the underlying cerebral lesion with special reference towards aetiologic background factors in a population-ba...

    Authors: Elsa Tillberg, Bengt Isberg and Jonas K. E. Persson

    Citation: BMC Pediatrics 2020 20:116

    Content type: Research article

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  10. Child maltreatment affects a significant number of children globally. Strategies have been developed to identify children suspected of having been exposed to maltreatment with the aim of reducing further maltr...

    Authors: Jill R. McTavish, Andrea Gonzalez, Nancy Santesso, Jennifer C. D. MacGregor, Chris McKee and Harriet L. MacMillan

    Citation: BMC Pediatrics 2020 20:113

    Content type: Research article

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  11. Ménétrier’s disease (MD) is a protein-losing gastropathy characterized by gastric hypertrophy, foveolar hyperplasia and hypoalbuminemia. MD is uncommon in childhood with nonspecific clinical symptoms, and the ...

    Authors: Jiewei Zhang, Yizhong Wang, Haifeng Liu, Yongmei Xiao and Ting Zhang

    Citation: BMC Pediatrics 2020 20:110

    Content type: Case report

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  12. Heated Humidified High Flow Nasal Cannula Oxygen Therapy (HHFNC) is increasingly used on the paediatric wards and High Dependency Units (HDU) for different types of pathologies and different age groups. We aim...

    Authors: Osama Hosheh, Christopher T. Edwards and Padmanabhan Ramnarayan

    Citation: BMC Pediatrics 2020 20:109

    Content type: Research article

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  13. Syncope is a common and often benign disorder presenting at the pediatric emergency department. Long-QT syndrome may be presented with syncope, ventricular arrhythmias or sudden death and is vital to exclude a...

    Authors: Björn Reynisson, Gustaf Tanghöj and Estelle Naumburg

    Citation: BMC Pediatrics 2020 20:107

    Content type: Research article

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  14. Low cardiac output syndrome (LCOS) is an important complication of cardiac surgery. It is associated with increased morbidity and mortality. The incidence of LCOS after surgery is high in patients with congeni...

    Authors: Xinwei Du, Hao Chen, Xiaoqi Song, Shunmin Wang, Zedong Hao, Lifeng Yin and Zhaohui Lu

    Citation: BMC Pediatrics 2020 20:87

    Content type: Research article

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  16. The occurrence of cardiovascular diseases and metabolic disorders steadily increases with the body mass index (BMI). Since the latter is not the best and earliest indicator of obesity and cardiovascular risk, ...

    Authors: Nataša Marčun Varda, Martina Medved and Laura Ojsteršek

    Citation: BMC Pediatrics 2020 20:81

    Content type: Research article

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  17. The term vascular anomalies include various vascular tumors and vascular malformations, among them infantile hemangiomas and capillary malformations are the most well-known associated diseases in early ages. M...

    Authors: Li Li, Bin Yang, Li Wei, Bin Zhang, Xiao-feng Han, Zi-gang Xu and Lin Ma

    Citation: BMC Pediatrics 2020 20:78

    Content type: Research article

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  18. Spinal epidural hematoma without significant trauma is a rare condition with potentially severe outcome. This case report and systematic review of the literature illustrates the clinical presentation, risk fac...

    Authors: Audrey Carlhan-Ledermann, Bernard Laubscher, Maja Steinlin, Christian T. Ulrich, Rajeev Kumar Verma, Mattia Rizzi, Rodolfo Maduri and Sebastian Grunt

    Citation: BMC Pediatrics 2020 20:77

    Content type: Case report

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  19. Ear (tympanostomy) tube (TT) placement is a common ambulatory surgery in children. Despite the commonality of this treatment, the long-term effects are unknown. The objective of this study was to determine the...

    Authors: Jason A. Beyea, Bonnie Cooke, Emily Rosen and Paul Nguyen

    Citation: BMC Pediatrics 2020 20:76

    Content type: Research article

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  20. Interpretation of abnormalities in liver function tests, especially in asymptomatic children, is a common problem faced by clinicians. Isolated elevation of aspartate aminotransferase may further puzzle physic...

    Authors: Pejman Rohani, Farid Imanzadeh, Aliakbar Sayyari, Maryam Kazemi Aghdam and Reza Shiari

    Citation: BMC Pediatrics 2020 20:73

    Content type: Case report

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  21. The mid-long term outcomes of posterior spinal fusion in pediatric neurofibromatosis type 1 (NF-1) patients are rarely reported, so does the effectiveness of itsorthopeidc maintenance function. This study aims...

    Authors: Siyi Cai, Zhengyao Li, Guixing Qiu, Jianxiong Shen, Hong Zhao, Yu Zhao, Yipeng Wang and Jianguo Zhang

    Citation: BMC Pediatrics 2020 20:63

    Content type: Research article

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  22. Necrotizing soft tissue infection of the ear following ear piercing is a very rare condition. It is easily misdiagnosed leading to reconstructive morbidities and mortality in neonates. High clinical suspicion ...

    Authors: U. U. Nnadozie, O. B. Ezeanosike, C. C. Maduba, D. C. Obu and U. S. D. Unigwe

    Citation: BMC Pediatrics 2020 20:54

    Content type: Case report

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  23. Short-chain enoyl-CoA hydratase (SCEH or ECHS1) deficiency is a rare congenital metabolic disorder caused by biallelic mutations in the ECHS gene. Clinical phenotype includes severe developmental delay, regres...

    Authors: Hua Yang and Dan Yu

    Citation: BMC Pediatrics 2020 20:50

    Content type: Case report

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  24. In the Swedish population-based follow-up program and national quality registry for individuals with cerebral palsy (CPUP), physiotherapy (PT) and occupational therapy (OT) treatments are regularly recorded al...

    Authors: Annika Lundkvist Josenby, Tomasz Czuba and Ann I. Alriksson-Schmidt

    Citation: BMC Pediatrics 2020 20:45

    Content type: Research article

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  25. Little is known whether children experience pain during hospital stay from the child’s own perspective or not. The existing studies tend to be based on a small number of children and therefore have limitations...

    Authors: V. Vejzovic, J. Bozic, G. Panova, M. Babajic and A-C Bramhagen

    Citation: BMC Pediatrics 2020 20:39

    Content type: Research article

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  26. Retinoblastoma is an ocular tumor in infants with cancer predisposition. Treatment of the rare tumor needs to be optimized for ocular preserved survival without second primary malignancy (SPM).

    Authors: Tamaki Ueda, Yuhki Koga, Hiroshi Yoshikawa, Mika Tanabe, Kanako Yamana, Utako Oba, Kentaro Nakashima, Hiroaki Ono, Takuya Ichimura, Shunji Hasegawa, Wakako Kato, Tetsuko Kobayashi, Hideki Nakayama, Yasunari Sakai, Tadamasa Yoshitake, Saiji Ohga…

    Citation: BMC Pediatrics 2020 20:37

    Content type: Research article

    Published on:

  27. The relationship between constipation and childhood nocturnal enuresis (NE) has been previously reported; however, this relationship remains controversial. The present study aimed to evaluate the association b...

    Authors: Yu-Chao Hsiao, Jen-Hung Wang, Chia-Ling Chang, Chia-Jung Hsieh and Ming-Chun Chen

    Citation: BMC Pediatrics 2020 20:35

    Content type: Research article

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  29. Intestinal parasites are the commonest cause of childhood diarrhea and malnutrition in Ethiopia. Information about intestinal parasites is the first fundamental step for designing intervention strategies again...

    Authors: Berhan Tsegaye, Amanuel Yoseph and Hunachew Beyene

    Citation: BMC Pediatrics 2020 20:28

    Content type: Research article

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  30. Uric acid has been identified as an important factor in the development of hypertension. If low birth weight (LBW) combined with catch-up growth (CUG) is associated with continuously elevated serum uric acid l...

    Authors: Bomi Park, Bohyun Park, Hye Ah Lee, Seonhwa Lee, Hyejin Han, Eunae Park, Su Jin Cho, Hae Soon Kim, Young Ju Kim, Eun-Hee Ha and Hyesook Park

    Citation: BMC Pediatrics 2020 20:23

    Content type: Research article

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  31. Tonsillitis, with associated tonsillar hypertrophy, is a common disease of childhood, yet it is rarely associated with sudden death due to airway obstruction. Lethal complications involving the inflamed tonsil...

    Authors: I. Nieuwoudt, P. Goussard, J. Verster and J. Dempers

    Citation: BMC Pediatrics 2020 20:22

    Content type: Case report

    Published on:

  32. Rapid magnetic resonance imaging (MRI) protocols may be effective in the emergency department (ED) to evaluate nontraumatic neurologic complaints. We evaluate neuroimaging (rapid MRI [rMRI]), head computerized...

    Authors: Sriram Ramgopal, Sabrina A. Karim, Subramanian Subramanian, Andre D. Furtado and Jennifer R. Marin

    Citation: BMC Pediatrics 2020 20:14

    Content type: Research article

    Published on:

  33. Muscle contractures are developing during childhood and may cause extensive problems in gait and every day functioning in children with cerebral palsy (CP). The aim of the present study was to evaluate how the...

    Authors: Merete Aarsland Fosdahl, Reidun Jahnsen, Are Hugo Pripp and Inger Holm

    Citation: BMC Pediatrics 2020 20:11

    Content type: Research article

    Published on:

  34. The aim of this study is to contribute to the knowledge base on the long-term outcomes of evidence-based medical interventions used to improve gross motor function in children and adolescents with Cerebral Palsy.

    Authors: Jane Valentine, Sue-Anne Davidson, Natasha Bear, Eve Blair, Lisa Paterson, Roslyn Ward, David Forbes and Catherine Elliott

    Citation: BMC Pediatrics 2020 20:7

    Content type: Research article

    Published on:

  35. The high HIV prevalence in South Africa may potentially be shaping the local adverse drug reaction (ADR) burden. We aimed to describe the prevalence and characteristics of serious ADRs at admission, and during...

    Authors: Johannes P. Mouton, Melony C. Fortuin-de Smidt, Nicole Jobanputra, Ushma Mehta, Annemie Stewart, Reneé de Waal, Karl-Günter Technau, Andrew Argent, Max Kroon, Christiaan Scott and Karen Cohen

    Citation: BMC Pediatrics 2020 20:3

    Content type: Research article

    Published on:

  36. Choice of insulin delivery for type 1 diabetes can be difficult for many parents and children. We evaluated decision coaching using a patient decision aid for helping youth with type 1 diabetes and parents dec...

    Authors: Margaret L. Lawson, Allyson L. Shephard, Bryan Feenstra, Laura Boland, Nadia Sourial and Dawn Stacey

    Citation: BMC Pediatrics 2020 20:1

    Content type: Research article

    Published on:

  37. Given its narrow therapeutic range, digoxin’s pharmacokinetic parameters in infants are difficult to predict due to variation in birth weight and gestational age, especially for critically ill newborns. There ...

    Authors: Shu-Hui Yao, Hsiang-Te Tsai, Wen-Lin Lin, Yu-Chieh Chen, Chiahung Chou and Hsiang-Wen Lin

    Citation: BMC Pediatrics 2019 19:517

    Content type: Research article

    Published on:

  38. Gynecomastia develops due to the reversed estradiol-to-Testosterone ratio in adolescence, and symptoms typically improve within 2 years. The causes vary widely, including estrogen excess and tumors, and surgic...

    Authors: Jung-Eun Moon, Cheol Woo Ko, Jung Dug Yang and Joon Seok Lee

    Citation: BMC Pediatrics 2019 19:515

    Content type: Case report

    Published on:

  39. Spinal cord injury without radiographic abnormality (SCIWORA) is defined as having “clinical symptoms of traumatic myelopathy with no radiographic or computed tomographic features of spinal fracture or instabi...

    Authors: Qin Chuan Liang, Bo Yang, Yun Hai Song, Pin Pin Gao, Ze Yang Xia and Nan Bao

    Citation: BMC Pediatrics 2019 19:513

    Content type: Case report

    Published on:

  40. Relatively little is known about weight management programs targeted toward young children with obesity. Using data from the Early Lifestyles Intervention program, we report outcomes from a referral-based, mul...

    Authors: Eric E. Wickel, Lamiaa Ali, Hollie Hawkins and Eden Hemming

    Citation: BMC Pediatrics 2019 19:504

    Content type: Research article

    Published on:

  41. The rapid triage and treatment system for paediatrics (RETTS-p) has been used by the emergency medical services (EMS) in the west of Sweden since 2014. The performance of the RETTS-p in the pre-hospital settin...

    Authors: Carl Magnusson, Johan Herlitz, Thomas Karlsson, Maria Jiménez-Herrera and Christer Axelsson

    Citation: BMC Pediatrics 2019 19:500

    Content type: Research article

    Published on:

  42. It is critically important to assess the prognostic value of NT-proBNP in the form of repeated measures among children undergoing surgery for congenital heart defects (CHD). The aim of the present study is to ...

    Authors: Fangqin Lin, Lingling Zheng, Yanqin Cui, Weidan Chen, Ramit Kumar Gupta, Huixian Li, Xinxin Chen, Huimin Xia and Huiying Liang

    Citation: BMC Pediatrics 2019 19:497

    Content type: Research article

    Published on:

  44. Problems arising from medicines usage are recognised as a key patient safety issue. Children are a particular concern, given that they are more likely than adults to experience medication-related harm. While p...

    Authors: Adam Sutherland, Denham L. Phipps, Stephen Tomlin and Darren M. Ashcroft

    Citation: BMC Pediatrics 2019 19:486

    Content type: Research Article

    Published on:

  46. Despite advances in the field of pediatric oncology, cancer remains a leading cause of death in children. The delays in cancer diagnosis may occur throughout the diagnostic pathway. Diagnosis of childhood canc...

    Authors: Alemseged Berhane, Tadele Hailu and Afework Mulugeta

    Citation: BMC Pediatrics 2019 19:478

    Content type: Research article

    Published on:

  47. In the last century, meconium peritonitis(MP)was once a highly fatal gastrointestinal. disease With the development of fetal radiological technology, abnormal signs, such as pseudocysts, can. be detected durin...

    Authors: Yi Jiang, Weihua Pan, Wenjie Wu, Weipeng Wang, Suna Sun and Jun Wang

    Citation: BMC Pediatrics 2019 19:473

    Content type: Research article

    Published on:

  48. The differences between the clinical characteristics and survival time in malignancy- and non-malignancy–associated secondary hemophagocytic lymphohistiocytosis (HLH) are unclear. Here, we describe the clinica...

    Authors: Hua Pan, Yongmin Huo and Lirong Sun

    Citation: BMC Pediatrics 2019 19:468

    Content type: Research article

    Published on:

  49. Because of practice variation and new developments in palliative pediatric care, the Dutch Association of Pediatrics decided to develop the clinical practice guideline (CPG) palliative care for children. With ...

    Authors: Dunja Dreesens, Lotte Veul, Jonne Westermann, Nicole Wijnands, Leontien Kremer, Trudy van der Weijden and Eduard Verhagen

    Citation: BMC Pediatrics 2019 19:467

    Content type: Research article

    Published on:

  50. Kasai procedure is the standard initial treatment of infants with biliary atresia. The key to perform a successful surgery is to accurately remove the fibrous portal plate near the liver hilum. Yet how to esti...

    Authors: Qiulong Shen, Yajun Chen, Chunhui Peng, Wenbo Pang, Zengmeng Wang, Dongyang Wu, Kai Wang and Xinjie Huang

    Citation: BMC Pediatrics 2019 19:465

    Content type: Research article

    Published on:

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