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General pediatric medicine and surgery

This section considers studies of general medicine and surgical intervention in children and adolescents.

Page 1 of 8

  1. Content type: Research article

    Behçet’s disease (BD) is a rare vasculitic disorder affecting all sizes of vessels. Among BD patients, 4 to 25% of patients with diagnosed age younger than 16 years old are defined as juvenile BD (JBD). This s...

    Authors: Ya-Chiao Hu, Yao-Hsu Yang, Yu-Tsan Lin, Li-Chieh Wang, Hsin-Hui Yu, Jyh-Hong Lee and Bor-Luen Chiang

    Citation: BMC Pediatrics 2019 19:232

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  2. Content type: Research article

    Neonatal bloodspot screening (NBS) identifies conditions to offer early intervention and minimize irreversible damage. NBS policies guide a comprehensive system including processes for storage of neonatal drie...

    Authors: Marleen E. Jansen, Lion J. M. van den Bosch, Marjolein J. Hendriks, Mariska M. J. Scheffer, Marie-Louise Heijnen, Conor M. W. Douglas and Carla G. van El

    Citation: BMC Pediatrics 2019 19:230

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  3. Content type: Case report

    Manganese is a critical trace element that not only has antioxidant properties, but also is essential for various metabolic pathways and neurotransmitters production. However, it can be toxic at high levels, p...

    Authors: Azita Tavasoli, Khadije Arjmandi Rafsanjani, Saba Hemmati, Marziyeh Mojbafan, Elham Zarei and Soudabeh Hosseini

    Citation: BMC Pediatrics 2019 19:229

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  4. Content type: Case report

    Scurvy is one of the oldest diseases known to mankind. Although presently rare in the developed world, scurvy was a common potentially fatal disease. In recent times, the most common risk factors for scurvy in...

    Authors: Robin M. Lund, Mara L. Becker, Steven Shapiro, Tyler Allison and Julia G. Harris

    Citation: BMC Pediatrics 2019 19:228

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  5. Content type: Case report

    Propranolol hydrochloride is the first-line agent recommended for the treatment of infantile hemangiomas (IH). Serious adverse effects of propranolol therapy for hemangiomas are infrequent.

    Authors: Ilirjana Bakalli, Elmira Kola, Robert Lluka, Ermela Celaj, Durim Sala, Inva Gjeta, Sashenka Sallabanda and Dea Klironomi

    Citation: BMC Pediatrics 2019 19:216

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  6. Content type: Research article

    Intussusception is a gastrointestinal condition in which early treatment is critical. Although its epidemiology and comorbidities have been studied, few studies have included the entire pediatric population of...

    Authors: Soojin Jo, In Seok Lim, Soo Ahn Chae, Sin Weon Yun, Na Mi Lee, Su Yeong Kim and Dae Yong Yi

    Citation: BMC Pediatrics 2019 19:211

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  7. Content type: Case report

    Gorham-Stout disease is a rare condition characterized by unifocal and massive type IV osteolysis (variant of idiopathic nonhereditary osteolytic disease) with a slow progression, which is self-limiting for so...

    Authors: Mario Edgar Tena-Sanabria, Larisa Yarindy Jesús-Mejenes, Gabriela Fuentes-Herrera, Félix Alejandro Álvarez-Martínez, Nora Patricia Victorio-García and Juan Carlos Núñez-Enríquez

    Citation: BMC Pediatrics 2019 19:206

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  8. Content type: Research article

    Pediatric ARDS still represents a difficult challenge in Pediatric Intensive Care Units (PICU). Among different treatments proposed, exogenous surfactant showed conflicting results. Aim of this multicenter ret...

    Authors: Andrea Wolfler, Marco Piastra, Angela Amigoni, Pierantonio Santuz, Eloisa Gitto, Emanuele Rossetti, Carmine Tinelli, Cinzia Montani, Fabio Savron, Simone Pizzi, Luigia D’amato, Maria Cristina Mondardini, Giorgio Conti and Annalisa De Silvestri

    Citation: BMC Pediatrics 2019 19:203

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  9. Content type: Case report

    Tetrahydrobiopterin (BH4) deficiencies are disorders affecting phenylalanine homeostasis, and catecholamine and serotonin biosynthesis. GTP-Cyclohydrolase I deficiency (OMIM 600225) is an extremely rare variant o...

    Authors: Kavinda Chandimal Dayasiri, Nayani Suraweera, Deepal Nawarathne, U. E. Senanayake, B. K. T. P. Dayanath, Eresha Jasinge and Kumudu Weerasekara

    Citation: BMC Pediatrics 2019 19:199

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  10. Content type: Research article

    The diagnosis of cow’s milk protein allergy(CMPA) may be easily misdiagnosed due to its lack of specific symptoms. Thus, experts have proposed the use of Cow’s milk-related symptom scores (CoMiSS) to predict C...

    Authors: Yongmei Zeng, Jiyong Zhang, Guoqing Dong, Peihui Liu, Fei Xiao, Weiyan Li, Liting Wang and Qianzhen Wu

    Citation: BMC Pediatrics 2019 19:191

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  11. Content type: Case report

    Neonatal renal vein thrombosis is a recognised cause of renal and inferior caval vein atresia (IVCA). However, the long-term impact of the condition is underrecognized with a high burden of morbidity for the p...

    Authors: Stefan Lauener, Anne Bütikofer, Sandra Eigenheer and Robert Escher

    Citation: BMC Pediatrics 2019 19:183

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  12. Content type: Research article

    A hospitalized patient’s length of stay (LOS) can have a significant impact on the performance and operating costs of a healthcare facility. Among pediatric patients, traumatic injuries are common causes of em...

    Authors: Suliman Alghnam, Jawaher Ali Towhari, Ibrahim Al Babtain, Muhannad Al Nahdi, Mohammed Hamad Aldebasi, Mahna Alyami and Hamad Alkhalaf

    Citation: BMC Pediatrics 2019 19:177

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  13. Content type: Research article

    Migraine is a disabling primary headache disorder that occurs in about 10 % of children and might lead to a lower quality of life. There are several possible migraine triggers in a patient’s environment, which...

    Authors: Lydia Stella Koller, Susanne C. Diesner and Peter Voitl

    Citation: BMC Pediatrics 2019 19:164

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  14. Content type: Research article

    Detecting and addressing aspiration early in children with dysphagia, such as those with cerebral palsy, is important for preventing aspiration pneumonia. The current gold standards for assessing aspiration ar...

    Authors: Nobukazu Tanaka, Kanji Nohara, Akihito Ueda, Tamami Katayama, Miyuki Ushio, Nami Fujii and Takayoshi Sakai

    Citation: BMC Pediatrics 2019 19:162

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  15. Content type: Research article

    Hypertension is an emerging disease in children and adolescents resulting in future morbidities. Cigarette smoking is one of the most studied contributing factors in this regard; however, there are contradicto...

    Authors: Mahshid Aryanpur, Mahmoud Yousefifard, Alireza Oraii, Gholamreza Heydari, Mehdi Kazempour-Dizaji, Hooman Sharifi, Mostafa Hosseini and Hamidreza Jamaati

    Citation: BMC Pediatrics 2019 19:161

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  16. Content type: Research article

    There is limited information available regarding the clinical management of intravenous immunoglobulin-resistant Kawasaki disease (KD). We aimed to evaluate the optimal treatment options for patients with refr...

    Authors: Han Chan, Huan Chi, Hui You, Mo Wang, Gaofu Zhang, Haiping Yang and Qiu Li

    Citation: BMC Pediatrics 2019 19:158

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  17. Content type: Case report

    Neurally adjusted ventilatory assist (NAVA) is an alternative to pressure support ventilation (PSV) potentially improving patient-ventilator interaction. During NAVA, diaphragmatic electrical activity (EAdi) i...

    Authors: Thomas Langer, Serena Baio, Giovanna Chidini, Tiziana Marchesi, Giacomo Grasselli, Antonio Pesenti and Edoardo Calderini

    Citation: BMC Pediatrics 2019 19:155

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  18. Content type: Research article

    Pediatricians are advised by the Austrian ministry of health to be vaccinated against diphtheria, tetanus, pertussis, poliomyelitis, measles, mumps, rubella, varicella, hepatitis A, hepatitis B, meningococcus ...

    Authors: Susanne C. Diesner, Sarah Peutlberger and Peter Voitl

    Citation: BMC Pediatrics 2019 19:153

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  19. Content type: Debate

    As the pediatric population requiring health services rises globally, developing countries are struggling to cater to the growing burden of non-communicable diseases - particularly those requiring specialized ...

    Authors: Amir Humza Sohail, Muhammad Hassaan Arif Maan, Mohammed Sachal and Muhammad Soban

    Citation: BMC Pediatrics 2019 19:152

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  20. Content type: Case report

    Juvenile xanthogranuloma (JXG) belongs to the heterogeneous group of non-Langerhans cell histiocytosis and is caused by an accumulation and proliferation of macrophages. In the majority of cases JXG is a disor...

    Authors: Michaela Höck, Bernhard Zelger, Gisela Schweigmann, Barbara Brunner, Bettina Zelger, Gabriele Kropshofer and Ursula Kiechl-Kohlendorfer

    Citation: BMC Pediatrics 2019 19:128

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  21. Content type: Research article

    To report first clinical experience on three cases of congenital complete heart block and the use of a pacemaker system with a maximum lower rate interval of 95 beats per minute.

    Authors: Stefan Kurath-Koller, Sabrina Schweintzger, Gernot Grangl, Ante Burmas, Andreas Gamillscheg and Martin Koestenberger

    Citation: BMC Pediatrics 2019 19:124

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  22. Content type: Research article

    Fever is a very common adaptive immune response in acute respiratory tract disorders during infancy. Antipyretic / analgesic drugs such as paracetamol (acetaminophen) are widely used to improve the comfort of ...

    Authors: Georg Seifert, Juliette Brandes-Schramm, Andrea Zimmermann, Walter Lehmacher and Wolfgang Kamin

    Citation: BMC Pediatrics 2019 19:119

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  23. Content type: Research article

    The aim was to investigate the incidence of postoperative complications to surgery for necrotizing enterocolitis (NEC) with primary focus on enterostomy related complications.

    Authors: Jens Kristian Bælum, Lars Rasmussen, Niels Qvist and Mark Bremholm Ellebæk

    Citation: BMC Pediatrics 2019 19:110

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  24. Content type: Research article

    To investigate the prevalence and risk factors of premature thelarche (PT) in girls and gynecomastia (GM) in boys in Southern China.

    Authors: Jianwei Zhang, Jinliang Xu, Lifang Liu, Xiaohua Xu, Xinxian Shu, Zhifeng Yang, Lanqiu LV, Xiding Cai, Xianjiang Jin, Zaiyan Gu and Junfen Fu

    Citation: BMC Pediatrics 2019 19:107

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  25. Content type: Case report

    Familial hypercholesterolaemia (FH) is the most common inherited metabolic disease with an autosomal dominant mode of inheritance. It is characterised by raised serum levels of total cholesterol (TC) and low-d...

    Authors: Noor Shafina Mohd Nor, Alyaa Mahmood Al-Khateeb, Yung-An Chua, Noor Alicezah Mohd Kasim and Hapizah Mohd Nawawi

    Citation: BMC Pediatrics 2019 19:106

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  26. Content type: Research article

    The prevalence of periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) syndrome is unknown. Although an uncommon condition, it is considered to be the most common autoinflammatory dis...

    Authors: C. Sparud-Lundin, S. Berg, A. Fasth, A. Karlsson and P. Wekell

    Citation: BMC Pediatrics 2019 19:99

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  27. Content type: Case report

    Total colonic and small bowel aganglionosis (TCSA) occurs in less than 1% of all Hirschsprung’s disease patients. Currently, the mainstay of treatment is surgery. However, in patients with TCSA, functional out...

    Authors: Fereshteh Salimi Jazi, Julia M. Chandler, Chad M. Thorson, Tiffany J. Sinclair, Florette K. Hazard, John A. Kerner, Sanjeev Dutta, James C.Y. Dunn and Stephanie D. Chao

    Citation: BMC Pediatrics 2019 19:93

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    The Correction to this article has been published in BMC Pediatrics 2019 19:172

  28. Content type: Research article

    Series of biochemical and haematological changes occur during the course of dengue infection, which vary depending on the clinical disease. The patterns of change are not well documented and identifying these ...

    Authors: Grace Angeline Malarnangai Kularatnam, Eresha Jasinge, Sunethra Gunasena, Dulani Samaranayake, Manouri Prasanta Senanayake and Vithanage Pujitha Wickramasinghe

    Citation: BMC Pediatrics 2019 19:87

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  29. Content type: Research article

    There is no gold standard in body composition measurement in pediatric patients with obesity. Therefore, the aim of this study was to investigate if there are any differences between two bioelectrical impedanc...

    Authors: Alexandra Kreissl, Anselm Jorda, Katharina Truschner, Gabriele Skacel and Susanne Greber-Platzer

    Citation: BMC Pediatrics 2019 19:84

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  30. Content type: Case report

    Cholecystoduodenostomy is a surgical procedure that bypasses the extrahepatic biliary tree and connects the gallbladder directly to the duodenum. This case describes the successful use of this procedure in a n...

    Authors: Laura K. Fawcett, John Widger, Guy M. Henry and Chee Y. Ooi

    Citation: BMC Pediatrics 2019 19:78

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  31. Content type: Case report

    Total parenteral nutrition (TPN) and biliary atresia (BA) are common causes of cholestasis in infancy. The diagnosis of BA is time sensitive due to an inverse correlation between age at intervention (hepatic p...

    Authors: Atu Agawu, Andrew Wehrman, Jennifer Pogoriler, Natalie A. Terry and Henry C. Lin

    Citation: BMC Pediatrics 2019 19:72

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  32. Content type: Research article

    The incidence of type 1 diabetes mellitus (T1DM) in Kuwait is amongst the highest in the world. Vitamin D is considered to be involved in immune modulation and its deficiency contribute to autoimmune destructi...

    Authors: Majedah A. Rasoul, Mohammad Z. Haider, Maria Al-Mahdi, Hessa Al-Kandari and Gursev S. Dhaunsi

    Citation: BMC Pediatrics 2019 19:71

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  33. Content type: Case report

    Primary lymphomas of the gastrointestinal tract are rare, accounting for only 1 to 4% of malignancies arising in the stomach, small intestine, or colon. The stomach is the most common extranodal site of lympho...

    Authors: Yu-Tang Chang, Ming-Yii Huang, Hsiang-Hung Shih, Chun-Chieh Wu, Tzu-Ying Lu and Pei-Chin Lin

    Citation: BMC Pediatrics 2019 19:63

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  34. Content type: Research article

    Postoperative fluid management in critically ill neonates and infants with capillary leak syndrome (CLS) and extensive volume overload after cardiac surgery on cardiopulmonary bypass is challenging. CLS is oft...

    Authors: Anne Kerling, Okan Toka, André Rüffer, Hanna Müller, Sheeraz Habash, Christel Weiss, Sven Dittrich and Julia Moosmann

    Citation: BMC Pediatrics 2019 19:57

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  35. Content type: Case report

    Abernethy malformation is an extremely rare congenital malformation characterised by an extrahepatic portosystemic shunt. Children with Abernathy malformation can develop hepatopulmonary syndrome (HPS) with pu...

    Authors: Lijian Xie, Yun Li, Xunwei Jiang, Jian Zhao and Tingting Xiao

    Citation: BMC Pediatrics 2019 19:55

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  36. Content type: Research article

    The literature suggests that 0.9 to 6% of infants who die unexpectedly may have had a metabolic disorder. At least 43 different inborn errors of metabolism (IEMs) have been associated with sudden death (SUDI)....

    Authors: F. H. de Bitencourt, I. V. D. Schwartz and F. S. L. Vianna

    Citation: BMC Pediatrics 2019 19:52

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  37. Content type: Research article

    Kawasaki disease (KD) is an acute febrile vasculitis that primarily affects children. Previous studies have shown that both innate and adapt immune systems are involved in the immunopathogenesis of KD. The fol...

    Authors: Meng Xu, Yanfang Jiang, Jinghua Wang, Deying Liu, Shaofeng Wang, Huanfa Yi and Sirui Yang

    Citation: BMC Pediatrics 2019 19:43

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  38. Content type: Case report

    Finding an abdominal mass or hematuria is the initial step in diagnosing Wilms tumor. As the first manifestation of Wilms tumor, it is exceedingly rare for pulmonary tumor embolism to present with cardiac arre...

    Authors: Atsuna Fukuda, Takeshi Isoda, Naoya Sakamoto, Keisuke Nakajima and Tetsuya Ohta

    Citation: BMC Pediatrics 2019 19:39

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  39. Content type: Study protocol

    Obesity in children and adolescents is an increasing problem associated with multiple co-morbidities including metabolic and endocrine changes, cardiovascular abnormalities, and impaired quality of life. Combi...

    Authors: Y. G. M. Roebroek, G. F. Paulus, E. G. A. H. van Mil, A. C. E. Vreugdenhil, B. Winkens, C. Nederkoorn, C. D. A. Stehouwer, J. W. M. Greve, N. D. Bouvy and L. W. E. van Heurn

    Citation: BMC Pediatrics 2019 19:34

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  40. Content type: Study protocol

    There is no established standard chemotherapy for recurrent pediatric solid tumors such as neuroblastoma and sarcoma. Since some of these tumor cells show dysfunctions in homologous recombination repair, the g...

    Authors: Masatoshi Takagi, Chitose Ogawa, Yuki Aoki-Nogami, Tomoko Iehara, Eri Ishibashi, Minoru Imai, Tetsuro Kihara, Kiyoshi Nobori, Kazuhisa Hasebe, Shuki Mizutani, Toshimi Kimura, Masashi Nagata, Masato Yasuhara, Kenichi Yoshimura, Pariko Yorozu, Hajime Hosoi…

    Citation: BMC Pediatrics 2019 19:31

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  41. Content type: Case report

    Idiopathic systemic capillary leak syndrome (ISCLS) is rare, and there has been about 32 cases reported in children worldwide since this disorder was first described in 1960. Clinical guidelines on the managem...

    Authors: Karen Ka Yan Leung, Jaime Sou Rosa Duque, Kwong-Man Yu, Kai-Ning Cheong, Patrick Chun-Yin Chong, Marco Hok-Kung Ho and Pak-Cheong Chow

    Citation: BMC Pediatrics 2019 19:28

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  42. Content type: Research article

    In resource-poor settings, transfused children often experience recurrence of severe anemia (SA) following discharge from hospital. This study determined the factors associated with recurrent severe anemia (RS...

    Authors: Aggrey Dhabangi, Richard Idro, Chandy C. John, Walter H. Dzik, Robert Opoka, Ronald Ssenyonga and Michael Boele van Hensbroek

    Citation: BMC Pediatrics 2019 19:27

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  43. Content type: Case report

    Pneumatosis intestinalis and portomesenteric venous gas are usually caused by necrotizing enterocolitis; however they can occur secondary to abusive abdominal trauma with bone fractures and bruising. It is dif...

    Authors: En-Pei Lee, Jainn-Jim Lin, Shao-Hsuan Hsia, Oi-Wa Chan and Han-Ping Wu

    Citation: BMC Pediatrics 2019 19:21

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  44. Content type: Research article

    In Middle Europe ultrasonography is the standard method used to screen for developmental dysplasia of the hip in infants. Our aim was to determine whether manual fixation of the child is equivalent to Graf’s t...

    Authors: Peter Voitl, Christian Sebelefsky, Sara Hosner, Astrid Woditschka, Susanne Diesner and Andreas Böck

    Citation: BMC Pediatrics 2019 19:14

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  45. Content type: Research article

    Extravasation injuries are caused by unintended leakages of fluids or medicines from intravenous lines but there is no consensus on the best treatment approaches, particularly in infants and young children.

    Authors: Mark Corbett, David Marshall, Melissa Harden, Sam Oddie, Robert Phillips and William McGuire

    Citation: BMC Pediatrics 2019 19:6

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