Table 1 Clinical and biochemical features of type 1 diabetes children

Age [years]

7.67(4.26)(1.00,15.00)

8.14(3.27)(2.17,13.25)

0.557

Gender [male %]

56.7%

75.8%

0.059

BMI [kg/m²]

17.76(2.95)(13.06,24.68)

17.11(1.83)(14.66,22.44)

0.681

T1D duration [years]

1.57(2.16)(0.04,9.00)

N/A

N/A

HbA1c [%]

9.63(2.47)(5.60,14.9)

5.05(0.60)(4.10,6.10)

 < 0.0001

Glucose [mmol/L]

9.40(4.58)(2.92,20.73)

4.71(0.50)(3.9,5.82)

 < 0.0001

Totalcholesterol [mmol/L]

4.90(0.91)(2.81,8.17)

4.91(0.71)(3.86,6.13)

0.345

HDL cholesterol [mmol/L]

1.39(0.44)(0.33,2.46)

1.36(0.16(0.94,1.65))

0.703

LDL cholesterol [mmol/L]

2.46(0.91)(0.70,4.81)

2.56(0.74)(0.70,3.75)

0.771

Triglycerides [mmol/L]

1.17(0.47)(0.40,2.44)

1.16(0.43)(0.39,1.83)

0.357

TDD [IU/kg]

0.94(0.23)(0.00,1.42)

N/A

N/A

Basal insulin dose [%of TDD]

33.47(16.13)(6.90,100.00)

N/A

N/A

FGF−19 [pg/mL]

226.52(18.95)(186.82,266.25)

240.08(23.53)(197.20,277.98)

0.03

VEGF [pg/mL]

227.95(48.65)(146.57,376.34)

205.92(28.27)(132.72,249.33)

0.016

sklotho [pg/mL]

2448.67(791.92)(1070.87,3923.97)

3083.55(1113.47)(969.70,5623.69)

0.011