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Table 2 Odds ratios (OR) and 95% confidence intervals (CI) from unadjusted and adjusted logistic regression analyses for risk of intellectual disability (ID) severity, and diagnostic categories among children with and without congenital heart defects (CHDs), Western Australia, Australia, 1983–2010

From: Intellectual disabilities and autism among children with congenital heart defects, Western Australia, 1983–2010

Severity of ID

 

Intellectual Disability (ID)a

(n = 653)

Mild/ Moderate IDa

(n = 595)

Severe IDa

(n = 58)

Unadjusted

OR (95% CI)

Adjusted

OR (95% CI)

Unadjusted

OR (95% CI)

Adjusted

OR (95% CI)

Unadjusted

OR (95% CI)

Adjusted

OR (95% CI)

Congenital Heart Defects (CHD)b

 No CHD

Referent

Referent

Referent

Referent

Referent

Referent

 Any CHD

5.66 (4.76, 6.72)

5.26 (4.42, 6.26)

5.11 (4.28, 6.10)

4.76 (3.98, 5.70)

30.65 (11.10, 84.65)

24.66 (9.72, 62.57)

CHD Severityb

  No CHD

Referent

Referent

Referent

Referent

Referent

Referent

 Mild CHD

6.34 (4.41, 9.09)

5.72 (3.97, 8.25)

5.11 (3.44, 7.61)

4.66 (3.12, 6.96)

62.35 (18.71, 207.83)

47.41 (15.48, 145.22)

 Moderate CHD

5.62 (4.70, 6.72)

5.28 (4.40, 6.32)

5.18 (4.31, 6.21)

4.87 (4.05, 5.86)

26.07 (9.29, 73.18)

21.35 (8.30, 54.89)

 Severe CHD

4.98 (3.56, 7.00)

4.47 (3.20, 6.25)

4.52 (3.18, 6.42)

4.07 (2.86, 5.78)

25.86 (6.93, 96.53)

22.08 (6.63, 73.58)

Diagnostic Categories

 

Autism with co-occurring IDa

(n = 60)

Biomedical IDa

(n = 215)

Unknown IDa

(n = 378)

Unadjusted

OR (95% CI)

Adjusted

OR (95% CI)

Unadjusted

OR (95% CI)

Adjusted

OR (95% CI)

Unadjusted

OR (95% CI)

Adjusted

OR (95% CI)

CHDb

 No CHD

Referent

Referent

Referent

Referent

Referent

Referent

 Any CHD

1.74 (1.04, 2.90)

1.76 (1.07, 2.88)

67.46 (31.75, 143.35)

59.69 (28.99, 122.92)

3.61 (2.93, 4.45)

3.27 (2.65, 4.05)

CHD Severityb

 No CHD

Referent

Referent

Referent

Referent

Referent

Referent

 Mild CHD

2.75 (0.84, 8.99)

3.23 (1.11, 9.38)

75.71 (31.24, 183.49)

65.41 (27.76, 154.14)

3.84 (2.33, 6.33)

3.45 (2.09, 5.70)

 Moderate CHD

1.58 (0.90, 2.76)

1.61 (0.94, 2.76)

64.83 (30.40, 138.26)

57.81 (27.98, 119.47)

3.73 (3.00, 4.63)

3.43 (2.75, 4.27)

 Severe CHD

1.83 (0.56, 5.96)

2.14 (0.74, 6.18)

70.94 (30.46, 165.22)

60.81 (26.92, 137.37)

2.55 (1.55, 4.19)

2.25 (1.38, 3.68)

  1. aBecause 83 children with certain isolated BPA codes were excluded from different CHD classifications but not from binary CHD, numbers in parenthesis display sample sizes for binary CHD. Sample sizes for different CHD classification are as follows, 643 children in ID, 589 children in mild/moderate ID, 54 children in severe ID, 59 children in autism with co-occurring ID, 209 children in biomedical ID, and 375 children in unknown ID
  2. bSeparate models were computed first treating CHD as a binary independent variable and then using different classifications of CHD. Both models adjusted for maternal race, infant sex, infant gestational age, maternal age, marital status, and birth time period