From: Inhaled nitric oxide in premature infants for preventing bronchopulmonary dysplasia: a meta-analysis
First author (Year) | Origin | Sites,n | Groups (T/C) | GA,wk | BW,g | Age at Enrollment | start/max iNO,ppm | Duration of iNO,d | Primary endpoints | Diagnostic criteria |
---|---|---|---|---|---|---|---|---|---|---|
Ballard 2006 [14] | USA | 21 | 294/288 | ≤32 | 500-1250 | 7-21d | 20/20 | ≥24 | death or BPD at 36 weeks | Walsh 2004 |
Dani 2006 [15] | Italy | 1 | 20/20 | <30 | T:937 ± 298a C:825 ± 299.3a | <7d | 10/10 | 4.1b | death or BPD at 36 weeks | Shennan 1988 |
Hasan 2017 [21] | Canada | 33 | 229/222 | <30 | <1250 | 5-14d | 20/20 | 24 | survival without BPD | NICHD |
Hascoet 2005 [27] | France, Belgium | 10 | 61/84 | <32 | – | 6-48 h | 5/10 | – | survival at 28 days of age | – |
Kinsella 2006 [16] | USA | 16 | 398/395 | ≤34 | 500-1250 | <48 h | 5/5 | 21 | death or BPD at 36 weeks | Toce 1984 |
Kinsella 2014 [22] | USA | 5 | 59/65 | ≤34 | 500-1250 | <72 h | 10/10 | ≥14 | death or BPD at 36 weeks | NICHD |
Mercier 2010 [23] | EUNO | 36 | 399/401 | 24-28 | >500 | <24 h | 5/5 | 7-21 | survival without BPD | NICHD |
Schreiber 2003 [17] | USA | 1 | 105/102 | <34 | <2000 | <72 h | 10/10 | 7 | death or CLD | Shennan 1988 |
Van Meurs 2005 [24] | USA | 16 | 210/210 | <34 | 401-1500 | 24 h | 5/10 | ≤14 | death or BPD at 36 weeks | NICHD |
Van Meurs 2007 [18] | USA | 16 | 14/15 | <34 | >1500 | 24 h | 5/10 | ≤14 | death or BPD at 36 weeks | Walsh 2004 |
Wei 2014 [25] | China | 1 | 30/30 | 26-34 | 1082-2350 | <7d | 5/10 | ≥7 or until the ventilator is removed | death or BPD at 36 weeks | NICHD |