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Table 1 Characteristics of the included studies in the meta-analysis

From: Inhaled nitric oxide in premature infants for preventing bronchopulmonary dysplasia: a meta-analysis

First author (Year)

Origin

Sites,n

Groups (T/C)

GA,wk

BW,g

Age at Enrollment

start/max iNO,ppm

Duration of iNO,d

Primary endpoints

Diagnostic criteria

Ballard 2006 [14]

USA

21

294/288

≤32

500-1250

7-21d

20/20

≥24

death or BPD at 36 weeks

Walsh 2004

Dani 2006 [15]

Italy

1

20/20

<30

T:937 ± 298a

C:825 ± 299.3a

<7d

10/10

4.1b

death or BPD at 36 weeks

Shennan 1988

Hasan 2017 [21]

Canada

33

229/222

<30

<1250

5-14d

20/20

24

survival without BPD

NICHD

Hascoet 2005 [27]

France, Belgium

10

61/84

<32

–

6-48 h

5/10

–

survival at 28 days of age

–

Kinsella 2006 [16]

USA

16

398/395

≤34

500-1250

<48 h

5/5

21

death or BPD at 36 weeks

Toce 1984

Kinsella 2014 [22]

USA

5

59/65

≤34

500-1250

<72 h

10/10

≥14

death or BPD at 36 weeks

NICHD

Mercier 2010 [23]

EUNO

36

399/401

24-28

>500

<24 h

5/5

7-21

survival without BPD

NICHD

Schreiber 2003 [17]

USA

1

105/102

<34

<2000

<72 h 

10/10

7

death or CLD

Shennan 1988

Van Meurs 2005 [24]

USA

16

210/210

<34

401-1500

24 h

5/10

≤14

death or BPD at 36 weeks

NICHD

Van Meurs 2007 [18]

USA

16

14/15

<34

>1500

24 h

5/10

≤14

death or BPD at 36 weeks

Walsh 2004

Wei 2014 [25]

China

1

30/30

26-34

1082-2350

<7d

5/10

≥7 or until the ventilator is removed

death or BPD at 36 weeks

NICHD

  1. -Not described in the article
  2. aMean ± SD
  3. bMedian