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Fig. 1 | BMC Pediatrics

Fig. 1

From: Diagnostic aid to subepidermal calcified nodule with dermoscopy and reflectance confocal microscopy: a case report

Fig. 1

A Clinical presentation of the lesion. A yellowish-white papule on the patient's left upper eyelid; B Dermatoscopy of the lesion shows closely grouped multiple yellowish-white clods surrounded by linear vessels (× 20 magnification); C RCM imaging of the lesion shows nests of hyperrefractile material at the level of the dermal–epidermal junction (green arrows) and irregularly hyperplastic spinous layer (red arrows) (VivaScope 1500, mosaic, 0.5 × 0.5 mm); D Histopathology of the lesion shows small amorphous basophilic deposits scattered throughout the dermis with small numbers of lymphocytes, hyperkeratosis of the epidermis, a thickened stratum spinosum, and a downward-directed basal-layer expansion (HE stain, scale bar = 500 μm); E Von Kossa stain demonstrating numerous black calcium deposits either in the form of small amorphous calcium (blue arrows) or in the form of fine granules (yellow arrows). (von Kossa stain, scale bar = 500 μm)

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