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Table 2 Clinical course of thyroid abnormalities

From: Characteristics and clinical course of thyroid abnormalities arisen in long term survivors of childhood cancer

Initial presentation

N

Median time from diagnosis of cancer (years)

Thyroid abnormalities (transient case)

Brain tumors

No Brain tumors

Irradiation group 1

Chemo only or irradiation group 2

Total

107

3.3(0–14.8)

49(11)

58(34)

73(24)

34(21)

Normal freeT4, TSH 4.5–10 mU/L

50

5.5(0–14.8)

13(9)

37(26)

28(18)

22(17)

Normal freeT4, TSH ≥ 10 mU/L

15

2.1(0–5.0)

6(1)

9(4)

13(4)

2(1)

Decreased freeT4, normal TSH

16

0.5(0–14.2)

16(0)

0(0)

13(0)

3(0)

Decreased freeT4, TSH 4.5–10 mU/L

2

0/0.1

2(0)

0(0)

2(0)

0(0)

Decreased freeT4, TSH ≥ 10 mU/L

3

2.2(0–3.4)

1(0)

2(0)

1(0)

2(0)

Autoimmune thyroiditis

5

1.0(0.7–4.7)

1(1)

4(2)

2(1)

3(2)

Secondary thyroid cancer

6

7.5(1.0–10.5)

0(0)

6(2)

4(1)

2(1)

Unknown

10

0

10(0)

0(0)

10(0)

0(0)

  1. FreeT4 Free thyroxine, TSH Thyroid stimulating hormone; The irradiation fileds of group 1 included head and neck, craniospinal irradiation, total body, cervical spine, nasopharynx, and mediastinum. The remaining irradiation fields (abdomen, pelvis, and limbs) were regarded as irradiation group 2