Table 5 Subgroup analysis of infection within 2 years of age and the risk of allergic rhinitis
No | OR (95%CI) | P | Heterogeneity | ||
|---|---|---|---|---|---|
All studies | 13 | 1.25 (1.12–1.40) | < 0.001 | I2 = 89% P < 0.001 | |
Cohort studies | 6 | 1.17 (1.06–1.29) | 0.001 | I2 = 80% 0.002 | |
Non-cohort studies | 7 | 1.51 (1.13–2.02) | 0.005 | I2 = 93% P < 0.001 | |
Outcome evaluation | |||||
Doctor's diagnosis | 3 | 2.05 (0.96 -4.35) | 0.06 | I2 = 95% P < 0.001 | |
Self-report | 3 | 1.29 (0.81–2.08) | 0.29 | I2 = 70% 0.03 | |
ISAAC | 5 | 1.17 (1.06–1.30) | 0.003 | I2 = 77% 0.002 | |
ISAAC + SPT | 1 | 1.08 (0.78–1.49) | 0.64 | NA NA | |
Upper respiratory tract infection | |||||
All studies | 7 | 1.32 (1.06–1.65) | 0.01 | I2 = 83% | P < 0.001 |
Cohort study | 1 | 1.22 (1.05–1.41) | 0.008 | NA | NA |
Non-cohort studies | 6 | 1.37 (1.02–1.85) | 0.02 | I2 = 85% | P < 0.001 |
Bronchitis | |||||
All studies | 3 | 0.98 (0.88–1.09) | 0.74 | I2 = 47% | 0.15 |
Cohort studies | 2 | 1.32 (0.87–2.00) | 0.97 | I2 = 41% | 0.19 |
Case control study | 1 | 0.96 (0.86–1.07) | 0.46 | NA | NA |
Lower respiratory tract | |||||
All studies | 5 | 1.16 (0.79–1.70) | 0.46 | I2 = 75% | 0.003 |
Cohort studies | 2 | 1.03 (0.63–1.68) | 0.9 | I2 = 0% | 0.89 |
Non-cohort studies | 3 | 1.24 (0.71–2.16) | 0.45 | I2 = 87% | 0.003 |
Ear infection | |||||
All studies | 5 | 1.06 (1.00–1.13) | 0.06 | I2 = 39% | 0.16 |
Cohort studies | 4 | 1.13 (1.04–1.22) | 0.003 | I2 = 0% | 0.97 |
Case control study | 1 | 0.96 (0.87–1.06) | 0.42 | NA | NA |
Gastrointestinal infection | |||||
All studies | 4 | 1.37 (1.01–1.86) | 0.04 | I2 = 91% | P < 0.001 |
Cohort study | 1 | 1.20 (1.05–1.37) | 0.007 | NA | NA |
Non-cohort studies | 3 | 1.70 (0.95–3.06) | 0.08 | I2 = 94% | P < 0.001 |
Urinary tract infection | |||||
All studies | 2 | 1.16 (0.83–1.63) | 0.39 | I2 = 70% | 0.07 |
Cohort study | 1 | 1.32 (1.23–1.41) | < 0.001 | NA | NA |
Case control study | 1 | 0.92 (0.63–1.35) | 0.67 | NA | NA |