Expression pattern of miR-193a, miR122, miR155, miR-15a, and miR146a in peripheral blood mononuclear cells of children with obesity and their relation to some metabolic and inflammatory biomarkers

Table 6 The comparison of miR-122 expression level among children with and without some metabolic status

Groups	N	Median (IQR)	^@P-value	Groups	N	Median (IQR)	^@P-value
Obesity			0.08	^**Muscle Mass Range			0.13
No	45	0.06 (0.28)		Low	41	0.05(0.33)
Yes	45	0.21(3.11)		Normal	24	0.16(2.00)
Metabolic syndrome			0.008	High	25	0.21(3.95)
No	76	0.06(0.33)		**Fat Mass			0.04
Yes	14	1.07(13.17)		Normal	55	0.06(0.25)
^&High TG			0.17	high	35	0.27(2.20)
No	50	0.06 (0.88)		^$$REE			0.09
Yes	40	0.22 (3.98)		^~Slow	10	0.57(2.75)
^&Low HDL			0.27	^~Normal	59	0.07(0.31)
No	67	0.08 (0.88)		^~Fast	21	0.09(18.32)
Yes	23	0.22 (3.98)		*High hs-CRP			0.04
^&Large WC			0.03	No	60	0.06(0.70)
No	67	0.21 (1.02)		Yes	29	0.31(3.07)
Yes	23	0.96 (1.56)		^%Hyper-insulinemia			0.30
^&High SBP			0.55	No	80	0.09 (1.39)
No	80	0.08(1.25)		Yes	10	0.21 (4.86)
Yes	10	0.24(14.6)		^#Insulin Resistance			0.06
^&High DBP			0.62	No	76	0.08(1.22)
No	39	0.091(1.53)		Yes	14	0.27(18.29)
Yes	51	0.02(1.35)

^@Mann–Whitney u Test or Kruskal–Wallis test
^& Normal Range according to metabolic syndrome definition in children
^**Desired range reported in each person's body analyzer result sheet, was considered for classification of muscle mass (low-normal-high) and fat mass (low-normal-high)
^$$ Classification for REE (slow-normal-fast) according to desirable ranges reported for each child in Indirect Calorimeter result sheet
^*hs-CRP Reference Value according to sex and age. Normal value in serum (mg/liter): Boys: 5–13 year < 1.45 and 14–18 year < 2.13/Girls: 5–13 year < 1.90 and 14–18 year < 3.33
^# HOMA-IR cut-off values for insulin resistance were calculated to be 2.67 (sensitivity 88.2%, specificity 65.5%) in boys and 2.22 (sensitivity 100%, specificity 42.3%) in girls in the prepubertal period, and 5.22 (sensitivity 56%, specificity 93.3%) in boys and 3.82 (sensitivity 77.1%, specificity 71.4%) in girls in the pubertal period

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