Expression pattern of miR-193a, miR122, miR155, miR-15a, and miR146a in peripheral blood mononuclear cells of children with obesity and their relation to some metabolic and inflammatory biomarkers

Table 5 The comparison of miR-193a expression level among children with and without some metabolic status

Groups	N	Median (IQR)	^@P-value	Groups	N	Median (IQR)	^@P-value
Obesity			0.07	^**Muscle Mass Range			0.09
No	45	0.64(0.68)		Low	41	0.56 (0.71)
Yes	45	1.01(0.81)		Normal	24	0.70 (0.59)
Metabolic syndrome			0.003	High	25	1.13 (0.82)
No	76	0.62(0.64)		^**Fat Mass			0.05
Yes	14	1.31(0.42)		Normal	55	0.67(0.64)
^&High TG			0.05	high	35	1.11(0.85)
No	50	0.64(0.65)		^$$REE			0.008
Yes	40	1.06(0.76)		^*Slow	10	^{*^}1.11(0.49)
^&Low HDL			0.07	Normal	59	0.59(0.65)
No	67	0.68 (0.64)		^*Fast	21	^{*^}1.61(0.49)
Yes	23	1.21 (0.80)		^*High hs-CRP			0.23
^&Large WC			0.01	No	60	0.70 (0.88)
No	67	0.64(0.64)		yes	29	0.85 (0.73)
Yes	23	1.31(0.75)		^%Hyper-insulinemia			0.38
^&High SBP			0.32	No	80	0.70(0.84)
No	80	0.70 (0.68)		Yes	10	0.80(0.87)
Yes	10	1.08 (1.12)		^#Insuline Resistance			0.04
^&High DBP			0.37	No	76	0.70(0.72)
No	39	0.70 (0.84)		Yes	14	1.13(1.10)
Yes	51	1 (0.83)		Yes	14	1.13(1.10)

^@Mann–Whitney u Test or Kruskal–Wallis test /^P-value = 0.05
^&Normal Range according to metabolic syndrome definition in children
^**Desired range reported in each person's body analyzer result sheet, was considered for classification of muscle mass (low-normal-high) and fat mass (low-normal-high)
^$$ Classification for REE (slow-normal-fast) according to desirable ranges reported for each child in Indirect Calorimeter result sheet
^*hs-CRP Reference Value according to sex and age. Normal value in serum (mg/liter): Boys: 5–13 year < 1.45 and 14–18 year < 2.13/Girls: 5–13 year < 1.90 and 14–18 year < 3.33
^%Fasting insulin levels above 15 μU/mL in the pre-pubertal period, 30 μU/mL in the pubertal period and 20 μU/mL in the post-pubertal period are cut-off levels for hyper insulinemia
^# HOMA-IR cut-off values for insulin resistance were calculated to be 2.67 (sensitivity 88.2%, specificity 65.5%) in boys and 2.22 (sensitivity 100%, specificity 42.3%) in girls in the prepubertal period, and 5.22 (sensitivity 56%, specificity 93.3%) in boys and 3.82 (sensitivity 77.1%, specificity 71.4%) in girls in the pubertal period

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