| Cooled n = 399 | Not Cooled n = 193 | p-value |
---|---|---|---|
Birth weight categories |  |  | < 0.001 |
 ≥ 2500 g | 348/399 (87.2) | 148/193 (76.7) |  |
 < 2500 g | 51/399 (12.8) | 45/193 (23.3) |  |
Mean birth weight, in grams | 3058 ± 508 | 2961 ± 565 | 0.036 |
Gestational age categories | Â | Â | 0.003 |
  ≥ 38 weeks | 312/397 (78.6) | 127/189 (67.2) |  |
 < 38 weeks | 85/397 (21.4) | 62/189 (32.8) |  |
Mean gestational age, in weeks | 38.1 ± 2.5 | 38.7 ± 2.2 | 0.006 |
Sex, male | 247/397 (62.2) | 118/193 (61.1) | 0.801 |
Apgar score at 5 min |  |  | < 0.001 |
 ≥ 4 | 331/392 (84.4) | 88/183 (48.1) |  |
 0–3 | 61/392 (15.6) | 95/183 (51.9) |  |
 Median Apgar score at 5 min | 5 (4–6) | 3 (2–6) | < 0.001 |
Time to First Breath |  |  | < 0.002 |
 < 20 min | 257/303 (84.8) | 67/110 (60.9) |  |
 ≥ 20 min | 46/303 (15.2) | 43/110 (39.1) |  |
 Median | 7 (3–13) | 14 (5–40) | < 0.001 |
Sarnat staging |  |  | < 0.001 |
 Stage 2 (moderate encephalopathy) | 359 (90.0) | 84 (43.5) |  |
 Stage 3 (severe encephalopathy) | 40 (10.0) | 109 (56.5) |  |
Thompson score |  |  | < 0.001 |
 ≤ 10 | 185/384 (48.2) | 43/148 (29.0) |  |
 > 10 | 199/384 (51.8) | 105/148 (71.0) |  |
 Median Thompson score | 11 (9–13) | 14 (10–16) | < 0.001 |
Blood gas, pH |  |  | < 0.001 |
 ≥ 7.00 | 253/398 (63.6) | 63/179 (32.2) |  |
 < 7.00 | 145/398 (36.4) | 116/179 (64.8) |  |
 Median pH | 7.05 (6.90–7.16) | 6.90 (6.70–7.10) | < 0.001 |
Blood gas, Base deficit (mmols/L) | Â | Â | 0.173 |
 ≤ 16.0 | 104/391 (26.6) | 48/177 (27.1) |  |
 > 16.0 | 287/391 (73.4) | 129/177 (72.9) |  |
 Median base deficit | 19.9 (16.0–24.0) | 22.3 (16.0–27.1) | 0.001 |