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Table 2 Univariate analysis comparing characteristics of neonates with moderate to severe encephalopathy between cooled and not cooled groups

From: Characteristics and outcomes of neonates with intrapartum asphyxia managed with therapeutic hypothermia in a public tertiary hospital in South Africa

 

Cooled

n = 399

Not Cooled

n = 193

p-value

Birth weight categories

  

< 0.001

 ≥ 2500 g

348/399 (87.2)

148/193 (76.7)

 

 < 2500 g

51/399 (12.8)

45/193 (23.3)

 

Mean birth weight, in grams

3058 ± 508

2961 ± 565

0.036

Gestational age categories

  

0.003

  ≥ 38 weeks

312/397 (78.6)

127/189 (67.2)

 

 < 38 weeks

85/397 (21.4)

62/189 (32.8)

 

Mean gestational age, in weeks

38.1 ± 2.5

38.7 ± 2.2

0.006

Sex, male

247/397 (62.2)

118/193 (61.1)

0.801

Apgar score at 5 min

  

< 0.001

 ≥ 4

331/392 (84.4)

88/183 (48.1)

 

 0–3

61/392 (15.6)

95/183 (51.9)

 

 Median Apgar score at 5 min

5 (4–6)

3 (2–6)

< 0.001

Time to First Breath

  

< 0.002

 < 20 min

257/303 (84.8)

67/110 (60.9)

 

 ≥ 20 min

46/303 (15.2)

43/110 (39.1)

 

 Median

7 (3–13)

14 (5–40)

< 0.001

Sarnat staging

  

< 0.001

 Stage 2 (moderate encephalopathy)

359 (90.0)

84 (43.5)

 

 Stage 3 (severe encephalopathy)

40 (10.0)

109 (56.5)

 

Thompson score

  

< 0.001

 ≤ 10

185/384 (48.2)

43/148 (29.0)

 

 > 10

199/384 (51.8)

105/148 (71.0)

 

 Median Thompson score

11 (9–13)

14 (10–16)

< 0.001

Blood gas, pH

  

< 0.001

 ≥ 7.00

253/398 (63.6)

63/179 (32.2)

 

 < 7.00

145/398 (36.4)

116/179 (64.8)

 

 Median pH

7.05 (6.90–7.16)

6.90 (6.70–7.10)

< 0.001

Blood gas, Base deficit (mmols/L)

  

0.173

 ≤ 16.0

104/391 (26.6)

48/177 (27.1)

 

 > 16.0

287/391 (73.4)

129/177 (72.9)

 

 Median base deficit

19.9 (16.0–24.0)

22.3 (16.0–27.1)

0.001