Author/ Year | Number of the participants | Study method | Diet/supplements intervention | primary outcome (findings) |
---|---|---|---|---|
Tang et al. 2019 [19] | Total:36 JIA:18 Control:18 | Randomised control trial | Cholecalciferol Vitamin D supplementation | Higher levels of serum 25OHD: P < 0.05 JADAS-27 was not significant: P > 0.05 No correlation between vitamin D, disease activity and BMD |
Stark et al. 2006 [20] | Total:49 BI group:25 ESC group:24 | Randomised clinical trial | Group 1: JRA received the 6-session BI increased to increase taking dietary calcium Group 2: JRA received 3-session ESC to increase Ca | Ca was significantly greater in the BI group (P < .001) 25-OH-D concentration did not differ between or within intervention group (p > .05) |
Dilandro et al. 2015 [12] | Total:22 JIA:12 Control:10 | Controlled trial | Biscuit supplementation contains iron | Decreased inflammatory indexes (particularly ESR) p = 0.002 No differences in changes were observed for serum iron and ferritin. (p = 0.621, 0.166 respectively) |
Golini and Jones. 2014 [21] | Total:16 | Clinical trial | Kre-Celazine nutritional Supplement composed of a proprietary alkali buffered creatine monohydrate and acetylated fatty acids mixture | Normal range of motion Decreased ESR and CRP Decreased pain scores |
Gheita et al. 2012 [22] | Total:47 JIA:27 Control:20 | Controlled trial | Dietary supplements of omega-3 FAs | A remarkable improvement in: mean active joint count (p < 0.001) JADAS-27 (p < 0.001) CHAQ (p < 0.001) A significant reduction in the ESR |
Yarema et al. 2018 [23] | Total:68 JIA:53 Control:15 | Randomised controlled trial | Dietary supplements of omega-3 PUFA | Immune status significantly improved:(≤ 0.05) |
Berntson et al.2014 [24] | 1 | case study | Full nutrition by EEN | Improvement in: global assessment of pain (VAS 0–100 mm) CHAQ JADAS 27 |
Berntson et al.2016 [24] | 1 | Pilot study | Full nutrition by EEN | A remarkable Improvement in: number of inflamed joints, morning stiffness, global assessment of pain (VAS 0–100 mm) CHAQ |
Berntson et al.2016 [24] | 7 | Exploratory study | Full nutrition by EEN | An immediate anti-inflammatory effect, as shown by reduction in inflammatory Proteins MCP-2, MCP-3 and MCP-4 (monocyte chemoattractant protein) resulting in clinical improvement in patients with JIA and decreased in levels of JADAS27, CHAQ and pain VAS |